ZA921230B - Improved activation of recombinant proteins - Google Patents

Improved activation of recombinant proteins

Info

Publication number
ZA921230B
ZA921230B ZA921230A ZA921230A ZA921230B ZA 921230 B ZA921230 B ZA 921230B ZA 921230 A ZA921230 A ZA 921230A ZA 921230 A ZA921230 A ZA 921230A ZA 921230 B ZA921230 B ZA 921230B
Authority
ZA
South Africa
Prior art keywords
recombinant proteins
amino acids
improved activation
helper sequences
relative hydrophobicities
Prior art date
Application number
ZA921230A
Other languages
English (en)
Inventor
Dorothea Ambrosius
Ambrosius Dorothea
Carola Dony
Dony Carola
Rainer Rudolph
Rudolph Rainer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6425597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA921230(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of ZA921230B publication Critical patent/ZA921230B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dental Preparations (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Adhesive Tapes (AREA)
ZA921230A 1991-02-21 1992-02-20 Improved activation of recombinant proteins ZA921230B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4105480A DE4105480A1 (de) 1991-02-21 1991-02-21 Verbesserte aktivierung von rekombinanten proteinen

Publications (1)

Publication Number Publication Date
ZA921230B true ZA921230B (en) 1992-11-25

Family

ID=6425597

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA921230A ZA921230B (en) 1991-02-21 1992-02-20 Improved activation of recombinant proteins

Country Status (20)

Country Link
US (1) US5578710A (fr)
EP (1) EP0500108B1 (fr)
JP (1) JP2528232B2 (fr)
KR (1) KR950014493B1 (fr)
AT (1) ATE144284T1 (fr)
AU (1) AU641081B2 (fr)
CA (1) CA2061569C (fr)
CZ (1) CZ282744B6 (fr)
DE (2) DE4105480A1 (fr)
DK (1) DK0500108T3 (fr)
ES (1) ES2093122T3 (fr)
FI (1) FI106029B (fr)
GR (1) GR3021395T3 (fr)
HU (1) HU214881B (fr)
IE (1) IE920276A1 (fr)
IL (1) IL101024A (fr)
MX (1) MX9200709A (fr)
NO (1) NO300329B1 (fr)
NZ (1) NZ241570A (fr)
ZA (1) ZA921230B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022431A1 (fr) * 1993-03-30 1994-10-13 Pharmacia Ab Preparation a liberation controlee contenant un sel de morphine

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5718893A (en) * 1984-04-15 1998-02-17 Foster; Preston F. Use of G-CSF to reduce acute rejection
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US5536495A (en) * 1994-04-15 1996-07-16 Foster; Preston F. Use of G-CSF to reduce acute rejection
US20030053982A1 (en) 1994-09-26 2003-03-20 Kinstler Olaf B. N-terminally chemically modified protein compositions and methods
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
MXPA03002046A (es) 2000-09-08 2003-07-24 Massachusetts Inst Technology Composiciones analogos de factor estimulador de colonias de granulocitos y metodos para su elaboracion.
KR100899970B1 (ko) 2001-02-19 2009-05-28 메르크 파텐트 게엠베하 Ｔ-세포 에피토프의 동정 방법 및 감소된 면역원성을 갖는분자의 제조를 위한 용도
AU2002325819B2 (en) 2001-07-11 2008-06-19 Maxygen, Inc. G-CSF Conjugates
AU2003210052A1 (en) 2002-03-20 2003-09-29 Biopolymed Inc. Preparation of g-csf stoichiometrically conjugated with biocompatible polymers at cystein residue
US7666627B2 (en) * 2002-08-08 2010-02-23 Targetex Kft. Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
US7695723B2 (en) 2002-12-31 2010-04-13 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
US7785601B2 (en) 2002-12-31 2010-08-31 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
US7220407B2 (en) 2003-10-27 2007-05-22 Amgen Inc. G-CSF therapy as an adjunct to reperfusion therapy in the treatment of acute myocardial infarction
CA2586365A1 (fr) 2004-11-05 2006-05-26 Northwestern University Utilisation de scf et de scf dans le traitement de l'ischemie cerebrale et des troubles neurologiques
CA2607844C (fr) 2005-06-01 2012-07-10 Maxygen Holdings Ltd. Polypeptides g-csf pegyles et procedes de production correspondants
EP2049524A2 (fr) * 2006-07-24 2009-04-22 Tetralogic Pharmaceuticals Corporation Inhibiteurs des iap
EP2185689A2 (fr) 2007-08-09 2010-05-19 Genzyme Corporation Procédé de traitement d'une maladie auto-immune avec des cellules souches mésenchymateuses
US8758761B2 (en) 2007-09-30 2014-06-24 University Of Florida Research Foundation, Inc. Combination therapies for treating type 1 diabetes
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
WO2011109556A2 (fr) 2010-03-04 2011-09-09 Pfenex Inc. Procédé pour la production de la protéine interféron recombinante soluble sans dénaturation
NZ601759A (en) * 2010-03-17 2013-07-26 Biogenerix Gmbh Method for obtaining biologically active recombinant human g-csf
WO2011123570A2 (fr) 2010-04-01 2011-10-06 Pfenex Inc. Procédés pour la production de g-csf dans une cellule hôte de pseudomonas
EP2880169B1 (fr) * 2012-08-02 2017-05-17 F. Hoffmann-La Roche AG Procédé de production de molécules monomères et multimères et leurs utilisations

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
US4530787A (en) * 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
US5082775A (en) * 1984-05-11 1992-01-21 Berlex Laboratories, Inc. Efficient process for isolating insoluble heterologous protein using non-ionic detergents
US4948729A (en) * 1985-03-25 1990-08-14 Cetus Corporation Production of soluble recombinant proteins
US4783415A (en) * 1985-03-28 1988-11-08 Meiji Seika Kabushiki Kaisha Gene coding for signal peptides and utilization thereof
US5087564A (en) * 1985-06-20 1992-02-11 Monsanto Company Release of recombinant peptides from polypeptides using V8 endopeptidase
DE3636903A1 (de) * 1985-12-21 1987-07-02 Hoechst Ag Fusionsproteine mit eukaryotischem ballastanteil
JPH0618781B2 (ja) * 1986-10-18 1994-03-16 中外製薬株式会社 感染症治療剤
US5013653A (en) * 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
AU605291B2 (en) * 1987-03-20 1991-01-10 Micromet Ag Process for the purification of recombinant polypeptides
WO1988010299A1 (fr) * 1987-06-24 1988-12-29 Novo-Nordisk A/S Procede de preparation d'une proteine ou d'un polypeptide, sequence d'adn codant pour le polypeptide, microorganisme contenant la sequence d'adn et le polypeptide et utilisation du polypeptide comme preparation pharmaceutique
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
ZA901719B (en) * 1989-03-19 1991-01-30 Akzo Nv Hog cholera virus vaccine and diagnostics
US5191063A (en) * 1989-05-02 1993-03-02 University Of Medicine And Dentistry Of New Jersey Production of biologically active polypeptides by treatment with an exogenous peptide sequence
US5115102A (en) * 1989-07-21 1992-05-19 Monsanto Company Variant proteins and polypeptides possessing enhanced affinity for immobilized-metal affinity matrices
JPH06500084A (ja) * 1990-08-20 1994-01-06 ノボ　ノルディスク　アクティーゼルスカブ 生物学的に活性な化合物、その製造方法及びその利用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022431A1 (fr) * 1993-03-30 1994-10-13 Pharmacia Ab Preparation a liberation controlee contenant un sel de morphine

Also Published As

Publication number Publication date
IE920276A1 (en) 1992-08-26
CA2061569A1 (fr) 1992-08-22
NO920671L (no) 1992-08-24
ES2093122T3 (es) 1996-12-16
DK0500108T3 (da) 1997-03-24
EP0500108A3 (en) 1993-04-07
HU214881B (hu) 1998-07-28
CS49992A3 (en) 1992-09-16
EP0500108A2 (fr) 1992-08-26
NO920671D0 (no) 1992-02-20
HUT68021A (en) 1995-04-04
US5578710A (en) 1996-11-26
HU9200548D0 (en) 1992-04-28
AU641081B2 (en) 1993-09-09
JPH05244977A (ja) 1993-09-24
IL101024A0 (en) 1992-11-15
JP2528232B2 (ja) 1996-08-28
FI920742A0 (fi) 1992-02-20
EP0500108B1 (fr) 1996-10-16
AU1094892A (en) 1992-08-27
KR920016464A (ko) 1992-09-24
GR3021395T3 (en) 1997-01-31
NZ241570A (en) 1994-09-27
ATE144284T1 (de) 1996-11-15
NO300329B1 (no) 1997-05-12
KR950014493B1 (ko) 1995-12-02
DE59207351D1 (de) 1996-11-21
FI920742A (fi) 1992-08-22
CZ282744B6 (cs) 1997-09-17
CA2061569C (fr) 2000-10-24
IL101024A (en) 1996-06-18
FI106029B (fi) 2000-11-15
DE4105480A1 (de) 1992-08-27
MX9200709A (es) 1992-09-01

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