ZA915658B - Analogs of hirudin having antiplatelet activity - Google Patents

Analogs of hirudin having antiplatelet activity

Info

Publication number
ZA915658B
ZA915658B ZA915658A ZA915658A ZA915658B ZA 915658 B ZA915658 B ZA 915658B ZA 915658 A ZA915658 A ZA 915658A ZA 915658 A ZA915658 A ZA 915658A ZA 915658 B ZA915658 B ZA 915658B
Authority
ZA
South Africa
Prior art keywords
hirudin
analogs
antiplatelet activity
antiplatelet
activity
Prior art date
Application number
ZA915658A
Other languages
English (en)
Inventor
John Leonard Krstenansky
Leonard Krstenansky John
Robert James Broersma Jr
James Broersma Robert Jr
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA915658B publication Critical patent/ZA915658B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • External Artificial Organs (AREA)
  • Corsets Or Brassieres (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA915658A 1990-07-24 1991-07-18 Analogs of hirudin having antiplatelet activity ZA915658B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55728990A 1990-07-24 1990-07-24

Publications (1)

Publication Number Publication Date
ZA915658B true ZA915658B (en) 1992-05-27

Family

ID=24224808

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA915658A ZA915658B (en) 1990-07-24 1991-07-18 Analogs of hirudin having antiplatelet activity

Country Status (10)

Country Link
EP (1) EP0468448B1 (cs)
JP (1) JP3264283B2 (cs)
KR (1) KR100200463B1 (cs)
AT (1) ATE139121T1 (cs)
AU (1) AU640502B2 (cs)
DE (1) DE69120158T2 (cs)
ES (1) ES2090181T3 (cs)
IE (1) IE72961B1 (cs)
TW (1) TW209171B (cs)
ZA (1) ZA915658B (cs)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0540574T3 (da) * 1990-07-24 1996-09-30 Merrell Pharma Inc Antikoagulationspeptider
FR2667071A1 (fr) * 1990-09-26 1992-03-27 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2686086A1 (fr) * 1992-01-15 1993-07-16 Adir Nouveaux derives de peptides et de pseudopeptides therapeutiquement actifs dans la cascade de coagulation sanguine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
ES2199963T3 (es) * 1993-06-11 2004-03-01 Merrell Pharmaceuticals Inc. Peptidos trifuncionales antitrombina y antiplaquetarios.
US5972648A (en) * 1993-09-28 1999-10-26 Japan Energy Corporation Hirudin analogs, methods of manufacture thereof and anticoagulant compositions having these as active ingredients
US7425533B2 (en) * 2003-06-26 2008-09-16 Merck Patent Gmbh Modified hirudin proteins and T-cell epitopes in hirudin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341032C (en) * 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
EP0333356A3 (en) * 1988-03-04 1990-12-19 Biogen, Inc. Hirudin peptides
FR2628429B1 (fr) * 1988-03-08 1990-12-28 Transgene Sa Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
NZ228995A (en) * 1988-05-10 1992-03-26 Merrell Dow Pharma Hirudin peptide derivatives and pharmaceutical compositions
AU630132B2 (en) * 1988-12-07 1992-10-22 Merrell Dow Pharmaceuticals Inc. Anticoagulant peptides
ZA907742B (en) * 1989-10-03 1991-07-31 Merrell Dow Pharma Anticoagulant peptides
CA2026377A1 (en) * 1989-10-03 1991-04-04 John L. Krstenansky Radiolabeled anticoagulant peptides

Also Published As

Publication number Publication date
EP0468448A2 (en) 1992-01-29
JPH04234327A (ja) 1992-08-24
AU640502B2 (en) 1993-08-26
ATE139121T1 (de) 1996-06-15
KR930001927A (ko) 1993-02-22
KR100200463B1 (ko) 1999-06-15
DE69120158T2 (de) 1996-10-31
AU8111091A (en) 1992-01-30
IE72961B1 (en) 1997-05-07
EP0468448B1 (en) 1996-06-12
ES2090181T3 (es) 1996-10-16
DE69120158D1 (de) 1996-07-18
EP0468448A3 (en) 1992-04-08
JP3264283B2 (ja) 2002-03-11
TW209171B (cs) 1993-07-11
IE912590A1 (en) 1992-01-29

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