ZA915171B - Sulfur-substituted mevinic acid derivatives - Google Patents

Sulfur-substituted mevinic acid derivatives

Info

Publication number
ZA915171B
ZA915171B ZA915171A ZA915171A ZA915171B ZA 915171 B ZA915171 B ZA 915171B ZA 915171 A ZA915171 A ZA 915171A ZA 915171 A ZA915171 A ZA 915171A ZA 915171 B ZA915171 B ZA 915171B
Authority
ZA
South Africa
Prior art keywords
sulfur
substituted
acid derivatives
mevinic acid
mevinic
Prior art date
Application number
ZA915171A
Other languages
English (en)
Inventor
Ravi K Varma
K Varma Ravi
Jeffrey O Saunders
O Saunders Jeffrey
Sam T Chao
T Chao Sam
Eric M Gordon
M Gordon Eric
Dinos P Santafianos
P Santafianos Dinos
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of ZA915171B publication Critical patent/ZA915171B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/20—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hydrogen atoms and substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D309/22—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
ZA915171A 1990-07-06 1991-07-03 Sulfur-substituted mevinic acid derivatives ZA915171B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54902490A 1990-07-06 1990-07-06

Publications (1)

Publication Number Publication Date
ZA915171B true ZA915171B (en) 1992-06-24

Family

ID=24191347

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA915171A ZA915171B (en) 1990-07-06 1991-07-03 Sulfur-substituted mevinic acid derivatives

Country Status (20)

Country Link
EP (1) EP0465265A1 (ja)
JP (1) JPH04230357A (ja)
KR (1) KR920002571A (ja)
CN (1) CN1058585A (ja)
AU (1) AU647492B2 (ja)
CA (1) CA2046171A1 (ja)
CS (1) CS207191A3 (ja)
FI (1) FI913285A (ja)
HU (1) HUT58682A (ja)
IE (1) IE912312A1 (ja)
IL (1) IL98721A0 (ja)
MX (1) MX9100095A (ja)
MY (1) MY106564A (ja)
NO (1) NO912636L (ja)
NZ (1) NZ238848A (ja)
PL (2) PL290954A1 (ja)
PT (1) PT98246A (ja)
RU (1) RU2041205C1 (ja)
TW (1) TW227552B (ja)
ZA (1) ZA915171B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369123A (en) * 1992-10-09 1994-11-29 E. R. Squibb & Sons, Inc. Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
GB2329334A (en) * 1997-09-18 1999-03-24 Reckitt & Colmann Prod Ltd Cholesterol-lowering agents
WO2019076269A1 (zh) 2017-10-16 2019-04-25 清华大学 甲羟戊酸通路抑制剂及其药物组合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT88364A (pt) * 1987-09-02 1989-07-31 Merck & Co Inc Process for preparing novel hmg-coa reductase inhibitors
US4866090A (en) * 1988-01-07 1989-09-12 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
FI893004A (fi) * 1988-06-29 1989-12-30 Merck & Co Inc 5-oxygenerade hmg-coa-reduktas -inhibitorer.
EP0415488B1 (en) * 1989-08-31 1994-04-20 Merck & Co. Inc. 7-Substituted HMG-COA reductase inhibitors

Also Published As

Publication number Publication date
FI913285A0 (fi) 1991-07-05
IL98721A0 (en) 1992-07-15
PL295149A1 (en) 1992-11-30
RU2041205C1 (ru) 1995-08-09
JPH04230357A (ja) 1992-08-19
NO912636D0 (no) 1991-07-05
IE912312A1 (en) 1992-01-15
CN1058585A (zh) 1992-02-12
MX9100095A (es) 1992-02-28
AU647492B2 (en) 1994-03-24
FI913285A (fi) 1992-01-07
PT98246A (pt) 1992-05-29
CS207191A3 (en) 1992-04-15
NO912636L (no) 1992-01-07
HU912287D0 (en) 1991-12-30
HUT58682A (en) 1992-03-30
TW227552B (ja) 1994-08-01
CA2046171A1 (en) 1992-01-07
PL290954A1 (en) 1992-11-16
KR920002571A (ko) 1992-02-28
EP0465265A1 (en) 1992-01-08
MY106564A (en) 1995-06-30
NZ238848A (en) 1993-06-25
AU8012091A (en) 1992-01-09

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