ZA915171B - Sulfur-substituted mevinic acid derivatives - Google Patents

Sulfur-substituted mevinic acid derivatives

Info

Publication number
ZA915171B
ZA915171B ZA915171A ZA915171A ZA915171B ZA 915171 B ZA915171 B ZA 915171B ZA 915171 A ZA915171 A ZA 915171A ZA 915171 A ZA915171 A ZA 915171A ZA 915171 B ZA915171 B ZA 915171B
Authority
ZA
South Africa
Prior art keywords
sulfur
substituted
acid derivatives
mevinic acid
mevinic
Prior art date
Application number
ZA915171A
Other languages
English (en)
Inventor
Ravi K Varma
K Varma Ravi
Jeffrey O Saunders
O Saunders Jeffrey
Sam T Chao
T Chao Sam
Eric M Gordon
M Gordon Eric
Dinos P Santafianos
P Santafianos Dinos
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of ZA915171B publication Critical patent/ZA915171B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/20Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hydrogen atoms and substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D309/22Radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/44Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C07C317/46Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/61Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA915171A 1990-07-06 1991-07-03 Sulfur-substituted mevinic acid derivatives ZA915171B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54902490A 1990-07-06 1990-07-06

Publications (1)

Publication Number Publication Date
ZA915171B true ZA915171B (en) 1992-06-24

Family

ID=24191347

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA915171A ZA915171B (en) 1990-07-06 1991-07-03 Sulfur-substituted mevinic acid derivatives

Country Status (20)

Country Link
EP (1) EP0465265A1 (xx)
JP (1) JPH04230357A (xx)
KR (1) KR920002571A (xx)
CN (1) CN1058585A (xx)
AU (1) AU647492B2 (xx)
CA (1) CA2046171A1 (xx)
CS (1) CS207191A3 (xx)
FI (1) FI913285A (xx)
HU (1) HUT58682A (xx)
IE (1) IE912312A1 (xx)
IL (1) IL98721A0 (xx)
MX (1) MX9100095A (xx)
MY (1) MY106564A (xx)
NO (1) NO912636L (xx)
NZ (1) NZ238848A (xx)
PL (2) PL290954A1 (xx)
PT (1) PT98246A (xx)
RU (1) RU2041205C1 (xx)
TW (1) TW227552B (xx)
ZA (1) ZA915171B (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5369123A (en) * 1992-10-09 1994-11-29 E. R. Squibb & Sons, Inc. Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
GB2329334A (en) * 1997-09-18 1999-03-24 Reckitt & Colmann Prod Ltd Cholesterol-lowering agents
KR20200066690A (ko) 2017-10-16 2020-06-10 칭화대학교 메발로네이트 경로 억제제 및 이의 약제학적 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT88364A (pt) * 1987-09-02 1989-07-31 Merck & Co Inc Process for preparing novel hmg-coa reductase inhibitors
US4866090A (en) * 1988-01-07 1989-09-12 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
FI893004A (fi) * 1988-06-29 1989-12-30 Merck & Co Inc 5-oxygenerade hmg-coa-reduktas -inhibitorer.
EP0415488B1 (en) * 1989-08-31 1994-04-20 Merck & Co. Inc. 7-Substituted HMG-COA reductase inhibitors

Also Published As

Publication number Publication date
PT98246A (pt) 1992-05-29
CN1058585A (zh) 1992-02-12
AU647492B2 (en) 1994-03-24
RU2041205C1 (ru) 1995-08-09
PL295149A1 (en) 1992-11-30
IE912312A1 (en) 1992-01-15
IL98721A0 (en) 1992-07-15
CA2046171A1 (en) 1992-01-07
TW227552B (xx) 1994-08-01
NO912636L (no) 1992-01-07
KR920002571A (ko) 1992-02-28
HU912287D0 (en) 1991-12-30
PL290954A1 (en) 1992-11-16
CS207191A3 (en) 1992-04-15
MY106564A (en) 1995-06-30
NZ238848A (en) 1993-06-25
MX9100095A (es) 1992-02-28
HUT58682A (en) 1992-03-30
AU8012091A (en) 1992-01-09
FI913285A0 (fi) 1991-07-05
EP0465265A1 (en) 1992-01-08
NO912636D0 (no) 1991-07-05
JPH04230357A (ja) 1992-08-19
FI913285A (fi) 1992-01-07

Similar Documents

Publication Publication Date Title
EP0520277A3 (en) 7-azaisoindolinyl-quinolone- and naphthyridoncarboxylic acid derivatives
PH30227A (en) 7-Isoindolinyl-quinolone-carboxylic acid derivatives
ZA94332B (en) Quinolone- and naphtyridonecarboxylic acid derivatives
IL103538A0 (en) Quinoxaline-carboxylic and-phosphonic acid derivatives
HU9203123D0 (en) Substituted imidazolyl-propenic acid derivatives
ZA93190B (en) Benzofuranyl- and thiophenylmethylthio-alkanecarboxylic acid derivatives
HU9403116D0 (en) Epoxy-succinic acid derivatives
ZA911398B (en) Carboxylic acid derivatives
HU9203124D0 (en) Imidazolyl-propenic acid derivatives
ZA913132B (en) Carboxylic acid derivatives
HU9400720D0 (en) Acyl-oxy-hexanic acid derivatives
HU9302728D0 (en) Pyridazinone-acetic acid derivatives
ZA915171B (en) Sulfur-substituted mevinic acid derivatives
HU9300544D0 (en) Sulfobenzyil-substituted imidazolyl-propane acid derivatives
ZW7994A1 (en) 2-oximino-2-thienyl-acetic acid derivatives
ZA916544B (en) Thiobutyric acid derivatives
ZA93125B (en) Quinolone- and naphthyridone-carboxylic acid derivatives
ZA941923B (en) Phenoxyphenylacetic acid derivatives
AP9100308A0 (en) Carboxymethylcyclopropane derivatives
HU9400588D0 (en) 3-hydroxyanthranilic acid derivatives
IL98802A0 (en) Cyclopropylacetic acid derivatives
ZA903999B (en) Mevinic acid derivatives
ZA922831B (en) Novel thienyl-nonatetraenoic acid derivatives
IE901971L (en) Mevinic acid derivatives
IE901047L (en) Thienylacetic acid derivatives