ZA911932B - Use of spiperone as an immunosuppressant and antiinflammatory agent - Google Patents

Use of spiperone as an immunosuppressant and antiinflammatory agent

Info

Publication number
ZA911932B
ZA911932B ZA911932A ZA911932A ZA911932B ZA 911932 B ZA911932 B ZA 911932B ZA 911932 A ZA911932 A ZA 911932A ZA 911932 A ZA911932 A ZA 911932A ZA 911932 B ZA911932 B ZA 911932B
Authority
ZA
South Africa
Prior art keywords
spiperone
mammal
immunosuppressant
antiinflammatory agent
neuroleptic
Prior art date
Application number
ZA911932A
Other languages
English (en)
Inventor
Richard J Sharpe
J Sharpe Richard
Kenneth A Arndt
A Arndt Kenneth
Stephen J Galli
J Galli Stephen
Original Assignee
Beth Israel Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital filed Critical Beth Israel Hospital
Publication of ZA911932B publication Critical patent/ZA911932B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA911932A 1990-03-16 1991-03-15 Use of spiperone as an immunosuppressant and antiinflammatory agent ZA911932B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49474090A 1990-03-16 1990-03-16

Publications (1)

Publication Number Publication Date
ZA911932B true ZA911932B (en) 1991-12-24

Family

ID=23965760

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA911932A ZA911932B (en) 1990-03-16 1991-03-15 Use of spiperone as an immunosuppressant and antiinflammatory agent

Country Status (13)

Country Link
US (1) US5290783A (de)
EP (1) EP0520032B1 (de)
JP (1) JPH078792B2 (de)
AT (1) ATE171067T1 (de)
CA (1) CA2077907C (de)
DE (1) DE69130216T2 (de)
DK (1) DK0520032T3 (de)
ES (1) ES2121779T3 (de)
IE (1) IE910882A1 (de)
NZ (1) NZ237422A (de)
PT (1) PT97057A (de)
WO (1) WO1991013622A1 (de)
ZA (1) ZA911932B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5574041A (en) * 1990-03-16 1996-11-12 Beth Israel Hospital Association Use of spiperone derivatives as immunosuppressant agents
AU3421493A (en) * 1991-12-27 1993-07-28 Beth Israel Hospital Use of spiperone or spiperone derivatives as immunosuppressant agents
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
CA2159091C (en) * 1993-03-26 2006-12-19 Richard J. Sharpe Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
US7226966B2 (en) 2001-08-03 2007-06-05 Nanogram Corporation Structures incorporating polymer-inorganic particle blends
WO1999059997A1 (en) * 1998-05-18 1999-11-25 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US20050191302A1 (en) * 2002-08-29 2005-09-01 University Of Southampton Treatment for liver disease
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
EA024559B1 (ru) 2009-05-06 2016-09-30 Лаборэтори Скин Кэа, Инк. Композиции для нанесения на кератинизированную поверхность кожи млекопитающего и способ доставки
EP2470270A1 (de) * 2009-07-31 2012-07-04 AnaMar AB Verbindungen zur behandlung von entzündungen
US8895962B2 (en) 2010-06-29 2014-11-25 Nanogram Corporation Silicon/germanium nanoparticle inks, laser pyrolysis reactors for the synthesis of nanoparticles and associated methods
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155670A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3155669A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3161644A (en) * 1962-06-22 1964-12-15 Res Lab Dr C Janssen N V 1-benzyl-4-substituted piperidines
US3238216A (en) * 1963-06-20 1966-03-01 Res Lab Dr C Janssen N V Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
BE792906A (fr) * 1971-12-18 1973-06-18 Sumitomo Chemical Co Aryl-cetones et leur preparation
US3996363A (en) * 1975-06-13 1976-12-07 E. R. Squibb & Sons, Inc. 2-[(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)alkyl]-1H-benz[de]isoquinolin-1,3(2H)-diones
JPS57182301A (en) * 1981-01-23 1982-11-10 Wellcome Found Composite body of sugar-containing compound and cycloamlose and manufacture
US4874766A (en) * 1986-09-22 1989-10-17 Janssen Pharmaceutica N.V. Method of promoting wound-healing
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
JPH01308274A (ja) * 1987-12-14 1989-12-12 Kyowa Hakko Kogyo Co Ltd 三環式化合物
ATE135216T1 (de) * 1989-08-21 1996-03-15 Beth Israel Hospital Verwendung von spiperone-derivate zur immunosuppression

Also Published As

Publication number Publication date
EP0520032A1 (de) 1992-12-30
ES2121779T3 (es) 1998-12-16
NZ237422A (en) 1997-06-24
DE69130216D1 (de) 1998-10-22
US5290783A (en) 1994-03-01
JPH078792B2 (ja) 1995-02-01
PT97057A (pt) 1991-12-31
CA2077907C (en) 1998-06-09
JPH05506855A (ja) 1993-10-07
EP0520032B1 (de) 1998-09-16
CA2077907A1 (en) 1991-09-17
EP0520032A4 (en) 1993-02-24
DE69130216T2 (de) 1999-03-25
WO1991013622A1 (en) 1991-09-19
ATE171067T1 (de) 1998-10-15
DK0520032T3 (da) 1999-06-14
IE910882A1 (en) 1991-09-25

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