DK0520032T3 - Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel - Google Patents

Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel

Info

Publication number
DK0520032T3
DK0520032T3 DK91907118T DK91907118T DK0520032T3 DK 0520032 T3 DK0520032 T3 DK 0520032T3 DK 91907118 T DK91907118 T DK 91907118T DK 91907118 T DK91907118 T DK 91907118T DK 0520032 T3 DK0520032 T3 DK 0520032T3
Authority
DK
Denmark
Prior art keywords
spiperone
mammal
immunosuppressive
inflammatory agent
neuroleptic
Prior art date
Application number
DK91907118T
Other languages
Danish (da)
English (en)
Inventor
J Sharpe Richard
A Arndt Kenneth
J Galli Stephen
Original Assignee
Beth Israel Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Hospital filed Critical Beth Israel Hospital
Application granted granted Critical
Publication of DK0520032T3 publication Critical patent/DK0520032T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK91907118T 1990-03-16 1991-03-13 Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel DK0520032T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49474090A 1990-03-16 1990-03-16
PCT/US1991/001684 WO1991013622A1 (en) 1990-03-16 1991-03-13 Use of spiperone as an immunosuppressant and anti-inflammatory agent

Publications (1)

Publication Number Publication Date
DK0520032T3 true DK0520032T3 (da) 1999-06-14

Family

ID=23965760

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91907118T DK0520032T3 (da) 1990-03-16 1991-03-13 Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel

Country Status (13)

Country Link
US (1) US5290783A (de)
EP (1) EP0520032B1 (de)
JP (1) JPH078792B2 (de)
AT (1) ATE171067T1 (de)
CA (1) CA2077907C (de)
DE (1) DE69130216T2 (de)
DK (1) DK0520032T3 (de)
ES (1) ES2121779T3 (de)
IE (1) IE910882A1 (de)
NZ (1) NZ237422A (de)
PT (1) PT97057A (de)
WO (1) WO1991013622A1 (de)
ZA (1) ZA911932B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703088A (en) * 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5574041A (en) * 1990-03-16 1996-11-12 Beth Israel Hospital Association Use of spiperone derivatives as immunosuppressant agents
EP0661972A1 (de) * 1991-12-27 1995-07-12 Beth Israel Hospital Verwendung von spiperon und spiperonderivaten als immunsuppressive wirkstoffe
US5693645A (en) * 1992-12-23 1997-12-02 Beth Israel Deaconess Medical Center, Inc. Use of spiperone or spiperone derivatives as immunosuppressant agents
US5484788A (en) * 1993-03-26 1996-01-16 Beth Israel Hospital Association Buspirone as a systemic immunosuppressant
WO1994022448A1 (en) * 1993-03-26 1994-10-13 Beth Israel Hospital Association Topical and systemic application of buspirone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5631017A (en) * 1993-03-26 1997-05-20 Beth Israel Deaconess Medical Center, Inc. Topical application of buspirone for treatment of pathological conditions associated with immune responses
US5637314A (en) * 1995-06-07 1997-06-10 Beth Israel Deaconess Medical Center, Inc. Topical and systemic application of buspirone or derivatives thereof for treating atopic dermatitis
US7226966B2 (en) 2001-08-03 2007-06-05 Nanogram Corporation Structures incorporating polymer-inorganic particle blends
AU3809999A (en) * 1998-05-18 1999-12-06 Novo Nordisk A/S Novel 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
US6277991B1 (en) 1998-05-18 2001-08-21 Novo Nordisk A/S 1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
EP2147679B1 (de) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Zusammensetzungen für den Blut-Hirn-Schrankentransport
AU2003259381A1 (en) * 2002-08-29 2004-03-19 University Of Southampton Use of apoptosis inducing agents in the preparation of a medicament for the treatment of liver diseases
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
EP2470270A1 (de) * 2009-07-31 2012-07-04 AnaMar AB Verbindungen zur behandlung von entzündungen
US8895962B2 (en) 2010-06-29 2014-11-25 Nanogram Corporation Silicon/germanium nanoparticle inks, laser pyrolysis reactors for the synthesis of nanoparticles and associated methods
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161644A (en) * 1962-06-22 1964-12-15 Res Lab Dr C Janssen N V 1-benzyl-4-substituted piperidines
US3155669A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 2, 4, 8-triaza-spiro (4, 5) dec-2-enes
US3155670A (en) * 1962-06-22 1964-11-03 Res Lab Dr C Janssen N V 1-oxo-2, 4, 8, triaza-spiro (4, 5) decanes
US3238216A (en) * 1963-06-20 1966-03-01 Res Lab Dr C Janssen N V Substituted 1, 3, 8-triaza-spiro (4, 5) decanes
BE792906A (fr) * 1971-12-18 1973-06-18 Sumitomo Chemical Co Aryl-cetones et leur preparation
US3996363A (en) * 1975-06-13 1976-12-07 E. R. Squibb & Sons, Inc. 2-[(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)alkyl]-1H-benz[de]isoquinolin-1,3(2H)-diones
AU558787B2 (en) * 1981-01-23 1987-02-12 Wellcome Foundation Limited, The Inclusion complexes of cyclodextrins and cardiac clycosides
US4874766A (en) * 1986-09-22 1989-10-17 Janssen Pharmaceutica N.V. Method of promoting wound-healing
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
JPH01308274A (ja) * 1987-12-14 1989-12-12 Kyowa Hakko Kogyo Co Ltd 三環式化合物
CA2065375A1 (en) * 1989-08-21 1991-02-22 Richard J. Sharpe Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists

Also Published As

Publication number Publication date
DE69130216D1 (de) 1998-10-22
EP0520032B1 (de) 1998-09-16
CA2077907A1 (en) 1991-09-17
CA2077907C (en) 1998-06-09
NZ237422A (en) 1997-06-24
ATE171067T1 (de) 1998-10-15
PT97057A (pt) 1991-12-31
JPH078792B2 (ja) 1995-02-01
EP0520032A1 (de) 1992-12-30
IE910882A1 (en) 1991-09-25
JPH05506855A (ja) 1993-10-07
US5290783A (en) 1994-03-01
DE69130216T2 (de) 1999-03-25
WO1991013622A1 (en) 1991-09-19
EP0520032A4 (en) 1993-02-24
ZA911932B (en) 1991-12-24
ES2121779T3 (es) 1998-12-16

Similar Documents

Publication Publication Date Title
DK0520032T3 (da) Anvendelse af spiperon som immunundertrykkende og antiinflammatorisk middel
AU536192B2 (en) Suppressing appetite for calories as carbohydrates
HN1998000143A (es) Tetrahidronaftalenos substituidos y compuestos analogos.
AR033325A1 (es) Composicion que comprende una carnitina y glutationa , util para incrementar la absorcion de la glutationa y sinergizar sus efectos, un complemento dietario, medicamento, la utilizacion de una composicion de combinacion para preparar un complemento dietario o un medicamento
IT1264530B (it) Impiego dei polisaccaridi nelle neuropatie atrofico degenerative
ES2143181T3 (es) Derivados biciclicos de isotiourea utiles en terapia.
FR2317909A1 (fr) Baton compacte non gras pour le maquillage, en particulier pour le maquillage des paupieres
NO144673C (no) Funksjonaliserte adeninderivater for anvendelse ved affinitetskromatografering og som ko-enzymer
ES458176A1 (es) Procedimiento para la preparacion de derivados de indazolil-(4)-oxi-propanolamina.
IT8348947A0 (it) Derivati del tiofene, loro preparazione e loro impiego come fungicidi
BR9103481A (pt) Composto,estereoisomero,composicao farmaceutica e processo para preparar um composto
DK145510C (da) Moebel med mindst to i forhold til hinanden drejelige moebeldele,som er indbyrdes forbundet ved hjaelp af mindst en haengselmekanisme
ES2191657T3 (es) Azaspiranos inmunomoduladores.
IT1197565B (it) Derivati del benzotiofene,loro preparazione e loro impiego come medicamenti
IT8323925A0 (it) Derivati bezilidenici solforati, loro preparazione e loro applicazione in terapia.
JPS52120132A (en) Remedies for nephric diseases
KR910019627A (ko) 화상 국부치료용 냉각제
FR2335721A1 (fr) Cheville, notmment pour l'ameublement
JPS5261295A (en) Curing of leaf tobacco
IT1141080B (it) L'applicazione in terapuetica come agenti analgesici dei derivati del 4,5,6,7-tetraidroisossazolo (5,4-c)piridin-3-ol
TH45580A (th) เครื่องสำเร็จของการแยกโดยการหมุนเหวี่ยง
FR96337E (fr) Dispositif contre l'absorption de goudrons de combustion, et notamment de la nicotine du tabac, par le fumeur, ainsi que l'outil pour le ramonage et l'entretien dudit dispositif.
MX9205233A (es) Uso de il-5 para tratar tumores solidos.
ES211801Y (es) Soporte perfeccionado doble para el eje de giro de butacas espectaculos.
AR226622A1 (es) Procedimiento para preparar una composicion farmaceutica para aplicacion topica,empleada en el tratamiento del acne