ZA908267B - 5-(2-((2-amino-2-oxoethyl)(methyl)amino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepin-4-one derivatives,their preparation and their application in therapy - Google Patents

5-(2-((2-amino-2-oxoethyl)(methyl)amino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepin-4-one derivatives,their preparation and their application in therapy

Info

Publication number
ZA908267B
ZA908267B ZA908267A ZA908267A ZA908267B ZA 908267 B ZA908267 B ZA 908267B ZA 908267 A ZA908267 A ZA 908267A ZA 908267 A ZA908267 A ZA 908267A ZA 908267 B ZA908267 B ZA 908267B
Authority
ZA
South Africa
Prior art keywords
amino
benzothiazepin
oxoethyl
methoxyphenyl
dihydro
Prior art date
Application number
ZA908267A
Other languages
English (en)
Inventor
Jean-Claude Muller
Muller Jean-Claude
Gilbert Lassalle
Lassalle Gilbert
Colombe Denys
Denys Colombe
Alistair Lochead
Lochead Alistair
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of ZA908267B publication Critical patent/ZA908267B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA908267A 1989-10-17 1990-10-16 5-(2-((2-amino-2-oxoethyl)(methyl)amino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepin-4-one derivatives,their preparation and their application in therapy ZA908267B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8913540A FR2653122B1 (fr) 1989-10-17 1989-10-17 Derives de 5-[2-[[2-amino-2-oxoethyl]methylamino]ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepine-4-one, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ZA908267B true ZA908267B (en) 1991-08-28

Family

ID=9386468

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA908267A ZA908267B (en) 1989-10-17 1990-10-16 5-(2-((2-amino-2-oxoethyl)(methyl)amino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepin-4-one derivatives,their preparation and their application in therapy

Country Status (14)

Country Link
EP (1) EP0424214A1 (xx)
JP (1) JPH03133970A (xx)
KR (1) KR910007901A (xx)
AU (1) AU6479690A (xx)
CA (1) CA2027738A1 (xx)
FI (1) FI905089A0 (xx)
FR (1) FR2653122B1 (xx)
HU (1) HUT57754A (xx)
IE (1) IE903720A1 (xx)
IL (1) IL95931A0 (xx)
NO (1) NO904470L (xx)
NZ (1) NZ235717A (xx)
PT (1) PT95606A (xx)
ZA (1) ZA908267B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69411387T2 (de) * 1994-09-16 1999-02-25 Orion Corp. FERMION, Espoo Verfahren zur Herstellung von pharmazeutisch aktiven Benzothiazepinderivaten.
WO2005035505A2 (en) * 2003-09-30 2005-04-21 Artesian Therapeutics, Inc. Compounds with phosphodiesterase inhibiting and calcium channel blocking activities

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH538492A (de) * 1970-10-07 1973-06-30 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
FR2624117B1 (fr) * 1987-12-08 1991-02-22 Synthelabo Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
FR2630109B1 (fr) * 1988-04-19 1991-11-29 Synthelabo Derives de ((n-(amino-2 oxo-2 ethyl)methylamino)-2 ethyl)-5 hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
IL95931A0 (en) 1991-07-18
NO904470L (no) 1991-04-18
NO904470D0 (no) 1990-10-16
FR2653122A1 (fr) 1991-04-19
JPH03133970A (ja) 1991-06-07
HUT57754A (en) 1991-12-30
EP0424214A1 (fr) 1991-04-24
AU6479690A (en) 1991-07-11
CA2027738A1 (en) 1991-04-18
HU906466D0 (en) 1991-04-29
FR2653122B1 (fr) 1994-04-15
FI905089A0 (fi) 1990-10-16
PT95606A (pt) 1991-09-13
IE903720A1 (en) 1991-04-24
NZ235717A (en) 1991-12-23
KR910007901A (ko) 1991-05-30

Similar Documents

Publication Publication Date Title
EP0352613A3 (en) Substituted amino methyl tetralines, and their heterocyclic analogous compounds
HU895900D0 (en) Process for the preparation of novel 2'-halogenomethylydene-, 2'-ethylydene and 2'-ethynylcytidine, uridine and guanosine derivatives
IL97821A0 (en) 3,5-disubstituted 2-isoxazolines and isoxazoles,processes for their preparation,agents containing them and their use
IL87339A0 (en) 2-((4-piperidyl)methyl)-1,2,3-4-tetrahydroisoquinoline derivatives,their preparation and their application in therapy
FR2681325B1 (fr) Derives de l'aminomethyl-4 piperidine, leur preparation et leur application en therapeutique.
IL97447A0 (en) Derivatives of 4-(aminomethyl)piperidine,their preparation and their therapeutic application
ZA905897B (en) 5-substituted 1,3,4-thiadiazole derivatives,their preparation and their use as pesticides
ZA913445B (en) Process for preparation of 1,5-(alkylimino)-1,5-dideoxy-d-glucitol and derivatives thereof
FI894546A (fi) Menetelmä uusien 2'-halogeenimetylideeni-, 2'-etenylideeni- ja 2'-etynyyliadenosiinijohdannaisten valmistamiseksi
FR2771093B1 (fr) Derives d'imidazole, leur preparation et leur application en therapeutique
FR2758329B1 (fr) Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique
ZA895271B (en) ((4-piperidyl)methyl)-2,3-dihydro-1h-isoindole and-2,3,4,5-tetrahydro-1h-benzazepine derivatives,their preparation and their application in therapy
ZA908267B (en) 5-(2-((2-amino-2-oxoethyl)(methyl)amino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepin-4-one derivatives,their preparation and their application in therapy
AU3909389A (en) Il-1alpha derivatives and medicament for treating thrombocytopenia
ZA889169B (en) 3-hydroxy-2-(4-methoxyphenyl)-5-(2-methylaminoethyl)-2,3-dihydro-5h-1,5-benzothiazepin-4-one derivatives,their preparation and their application in therapy
GB9805000D0 (en) Derivatives of 7-deaza-2-deoxy-guanosine-5'-triphosphate, preparation and use thereof
FR2772378B1 (fr) Derives d'imidazole, leur preparation et leur application en therapeutique
IL90909A0 (en) ((4-piperidyl)methyl)-2.3-dihydro-1h-isoindole and-2.3.4.5.-tetrahydro-1h-benzazepine derivatives their preparation and their application in therapy
IL97859A0 (en) 1,5-benzothiazepinone derivatives,their preparation and pharmaceutical use
GB9206062D0 (en) Heterocyclic compounds,their preparation and pharmaceutical use
ITMI920145A1 (it) Procedimento per l'iniettofusione di parti sagomate in materia artificiale
IL108342A0 (en) Salts of 4-pyrimidinone derivatives, their preparation and their therapeutic application
ZA907628B (en) 3-isoxazolone derivatives,their preparation and their therapeutic uses
CS549688A1 (en) 1-substituted 3-/2-(3-cyan-4,5,6,m-tetrahydrobenzo/b/thienyl)/thiourea and method of its preparation
ZA885786B (en) 2-(4-piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives,their preparations and their application in therapy