ZA908267B - 5-(2-((2-amino-2-oxoethyl)(methyl)amino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepin-4-one derivatives,their preparation and their application in therapy - Google Patents

5-(2-((2-amino-2-oxoethyl)(methyl)amino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepin-4-one derivatives,their preparation and their application in therapy

Info

Publication number
ZA908267B
ZA908267B ZA908267A ZA908267A ZA908267B ZA 908267 B ZA908267 B ZA 908267B ZA 908267 A ZA908267 A ZA 908267A ZA 908267 A ZA908267 A ZA 908267A ZA 908267 B ZA908267 B ZA 908267B
Authority
ZA
South Africa
Prior art keywords
amino
benzothiazepin
oxoethyl
methoxyphenyl
dihydro
Prior art date
Application number
ZA908267A
Other languages
English (en)
Inventor
Jean-Claude Muller
Muller Jean-Claude
Gilbert Lassalle
Lassalle Gilbert
Colombe Denys
Denys Colombe
Alistair Lochead
Lochead Alistair
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of ZA908267B publication Critical patent/ZA908267B/xx

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D281/00Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02Seven-membered rings
    • C07D281/04Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA908267A 1989-10-17 1990-10-16 5-(2-((2-amino-2-oxoethyl)(methyl)amino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepin-4-one derivatives,their preparation and their application in therapy ZA908267B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8913540A FR2653122B1 (fr) 1989-10-17 1989-10-17 Derives de 5-[2-[[2-amino-2-oxoethyl]methylamino]ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepine-4-one, leur preparation et leur application en therapeutique.

Publications (1)

Publication Number Publication Date
ZA908267B true ZA908267B (en) 1991-08-28

Family

ID=9386468

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA908267A ZA908267B (en) 1989-10-17 1990-10-16 5-(2-((2-amino-2-oxoethyl)(methyl)amino)ethyl)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5(5h)-benzothiazepin-4-one derivatives,their preparation and their application in therapy

Country Status (14)

Country Link
EP (1) EP0424214A1 (xx)
JP (1) JPH03133970A (xx)
KR (1) KR910007901A (xx)
AU (1) AU6479690A (xx)
CA (1) CA2027738A1 (xx)
FI (1) FI905089A0 (xx)
FR (1) FR2653122B1 (xx)
HU (1) HUT57754A (xx)
IE (1) IE903720A1 (xx)
IL (1) IL95931A0 (xx)
NO (1) NO904470L (xx)
NZ (1) NZ235717A (xx)
PT (1) PT95606A (xx)
ZA (1) ZA908267B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69411387T2 (de) * 1994-09-16 1999-02-25 Orion Corp. FERMION, Espoo Verfahren zur Herstellung von pharmazeutisch aktiven Benzothiazepinderivaten.
WO2005035505A2 (en) * 2003-09-30 2005-04-21 Artesian Therapeutics, Inc. Compounds with phosphodiesterase inhibiting and calcium channel blocking activities

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH538492A (de) * 1970-10-07 1973-06-30 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
FR2624117B1 (fr) * 1987-12-08 1991-02-22 Synthelabo Derives de hydroxy-3 (methoxy-4 phenyl)-2 (methylamino-2 ethyl)-5 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique
FR2630109B1 (fr) * 1988-04-19 1991-11-29 Synthelabo Derives de ((n-(amino-2 oxo-2 ethyl)methylamino)-2 ethyl)-5 hydroxy-3 (methoxy-4 phenyl)-2 dihydro-2,3 5h-benzothiazepine-1,5 one-4, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
IL95931A0 (en) 1991-07-18
NO904470L (no) 1991-04-18
NO904470D0 (no) 1990-10-16
FR2653122A1 (fr) 1991-04-19
JPH03133970A (ja) 1991-06-07
HUT57754A (en) 1991-12-30
EP0424214A1 (fr) 1991-04-24
AU6479690A (en) 1991-07-11
CA2027738A1 (en) 1991-04-18
HU906466D0 (en) 1991-04-29
FR2653122B1 (fr) 1994-04-15
FI905089A0 (fi) 1990-10-16
PT95606A (pt) 1991-09-13
IE903720A1 (en) 1991-04-24
NZ235717A (en) 1991-12-23
KR910007901A (ko) 1991-05-30

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