ZA906050B - 1,3-dihydro-1-(pyridinylamino)-2h-indol-2-ones,a process for their preparation and their use as medicaments - Google Patents
1,3-dihydro-1-(pyridinylamino)-2h-indol-2-ones,a process for their preparation and their use as medicamentsInfo
- Publication number
- ZA906050B ZA906050B ZA906050A ZA906050A ZA906050B ZA 906050 B ZA906050 B ZA 906050B ZA 906050 A ZA906050 A ZA 906050A ZA 906050 A ZA906050 A ZA 906050A ZA 906050 B ZA906050 B ZA 906050B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyridinylamino
- indol
- dihydro
- ones
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- -1 pyridinylethyl Chemical group 0.000 abstract 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- OGVQEEQFSPISNN-UHFFFAOYSA-N 1-(pyridin-2-ylamino)-3h-indol-2-one Chemical class O=C1CC2=CC=CC=C2N1NC1=CC=CC=N1 OGVQEEQFSPISNN-UHFFFAOYSA-N 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- DHXVGJBLRPWPCS-UHFFFAOYSA-N Tetrahydropyran Chemical compound C1CCOCC1 DHXVGJBLRPWPCS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 229940125681 anticonvulsant agent Drugs 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000006513 pyridinyl methyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/388,437 US5006537A (en) | 1989-08-02 | 1989-08-02 | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
| US07/535,640 US5053511A (en) | 1989-08-02 | 1990-06-11 | 1,3-dihydro-1-(pyridinylamino)-2h-indol-2-ones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA906050B true ZA906050B (en) | 1991-05-29 |
Family
ID=27012314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA906050A ZA906050B (en) | 1989-08-02 | 1990-08-01 | 1,3-dihydro-1-(pyridinylamino)-2h-indol-2-ones,a process for their preparation and their use as medicaments |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US5006537A (es) |
| EP (1) | EP0415102B1 (es) |
| JP (1) | JPH0674265B2 (es) |
| KR (2) | KR0169108B1 (es) |
| AT (1) | ATE118001T1 (es) |
| AU (2) | AU628202B2 (es) |
| CA (1) | CA2022486C (es) |
| DE (1) | DE69016530T2 (es) |
| DK (1) | DK0415102T3 (es) |
| ES (1) | ES2068293T3 (es) |
| FI (1) | FI903819A0 (es) |
| GR (1) | GR3015227T3 (es) |
| IE (1) | IE67045B1 (es) |
| IL (1) | IL95252A0 (es) |
| NO (1) | NO903389L (es) |
| NZ (1) | NZ234725A (es) |
| PT (1) | PT94879B (es) |
| ZA (1) | ZA906050B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
| US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
| US5296488A (en) * | 1989-08-02 | 1994-03-22 | Hoechst-Roussel Pharmaceuticals Inc. | Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory |
| US4914102A (en) * | 1989-09-28 | 1990-04-03 | Hoechst Roussel Pharmaceuticals, Inc. | N-aminocarbamates related to physostigmine, pharmacentical compositions and use |
| US5076835A (en) * | 1990-05-31 | 1991-12-31 | America Cyanamid Company | Aryloxyspiroalkylindolinone herbicides |
| US5102891A (en) * | 1990-07-23 | 1992-04-07 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates |
| US5264442A (en) * | 1990-08-13 | 1993-11-23 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs |
| US5214038A (en) * | 1991-04-15 | 1993-05-25 | Hoechst-Roussel Pharmaceuticals Inc. | 1-(pyrido[3,4-b]-1,4-oxazinyl-4-yl)-1H-indoles and intermediates for the preparation thereof |
| US5185350A (en) * | 1991-09-23 | 1993-02-09 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1h-indoles,1h-indazoles,2h-indazoles, benzo (b)thiophenes and 1,2-benzisothiazoles |
| US5246947A (en) * | 1991-09-23 | 1993-09-21 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression |
| EP0623127B1 (en) * | 1992-01-16 | 1997-04-02 | The Du Pont Merck Pharmaceutical Company | Novel neurotransmitter releasers useful for cognition enhancement |
| RU2051151C1 (ru) * | 1992-01-16 | 1995-12-27 | Дзе Дюпон Мерк Фармасьютикал Компани | Азотсодержащие гетероциклические производные флуорена |
| US5278162A (en) * | 1992-09-18 | 1994-01-11 | The Du Pont Merck Pharmaceutical Company | 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man |
| US5296478A (en) * | 1992-10-07 | 1994-03-22 | The Dupont Merck Pharmaceutical Co. | 1-substituted oxindoles as cognition enhancers |
| FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
| JP3004728B2 (ja) * | 1994-04-29 | 2000-01-31 | ファイザー インク． | 神経伝達物質放出増強薬としての新規な非環式および環式アミド類 |
| HUP9802413A3 (en) * | 1995-07-27 | 2002-02-28 | Aventis Pharmaceuticals Inc Br | Use of n-(pyrrol-1-yl)pyridinamines as anticonvulsant agents and for the preparation of a pharmaceutical composition for the treatment of convulsions |
| US6100276A (en) * | 1996-04-12 | 2000-08-08 | Aventis Pharmaceuticals Inc. | Isatin derivatives as acetylcholinesterase inhibitors and analgesics |
| IL126308A0 (en) * | 1996-04-12 | 1999-05-09 | Hoechst Marion Roussel Inc | Isatin derivatives as acetylcholinesterase inhibitors and analgesics |
| DK0950056T3 (da) * | 1996-12-27 | 2003-01-27 | Aventis Pharma Inc | N-(pyridinylamino)isoindoliner og beslægtede forbindelser |
| KR100507145B1 (ko) * | 2002-06-20 | 2005-08-09 | 현대자동차주식회사 | 차량의 전원제어장치 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4260767A (en) * | 1979-12-26 | 1981-04-07 | American Cyanamid Company | 2-Pyridylhydrazides |
| US4569942A (en) * | 1984-05-04 | 1986-02-11 | Pfizer Inc. | N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents |
| EP0287982B1 (en) * | 1987-04-24 | 1994-12-07 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments |
| US4983615A (en) * | 1989-06-28 | 1991-01-08 | Hoechst-Roussel Pharmaceuticals Inc. | Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders |
| US5006537A (en) * | 1989-08-02 | 1991-04-09 | Hoechst-Roussel Pharmaceuticals, Inc. | 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones |
-
1989
- 1989-08-02 US US07/388,437 patent/US5006537A/en not_active Expired - Lifetime
-
1990
- 1990-06-11 US US07/535,640 patent/US5053511A/en not_active Expired - Lifetime
- 1990-07-31 AT AT90114660T patent/ATE118001T1/de not_active IP Right Cessation
- 1990-07-31 ES ES90114660T patent/ES2068293T3/es not_active Expired - Lifetime
- 1990-07-31 IL IL95252A patent/IL95252A0/xx active IP Right Grant
- 1990-07-31 DK DK90114660.5T patent/DK0415102T3/da active
- 1990-07-31 NZ NZ234725A patent/NZ234725A/xx unknown
- 1990-07-31 FI FI903819A patent/FI903819A0/fi not_active Application Discontinuation
- 1990-07-31 EP EP90114660A patent/EP0415102B1/en not_active Expired - Lifetime
- 1990-07-31 DE DE69016530T patent/DE69016530T2/de not_active Expired - Lifetime
- 1990-08-01 KR KR1019900011818A patent/KR0169108B1/ko not_active IP Right Cessation
- 1990-08-01 CA CA002022486A patent/CA2022486C/en not_active Expired - Lifetime
- 1990-08-01 AU AU60004/90A patent/AU628202B2/en not_active Ceased
- 1990-08-01 JP JP2202618A patent/JPH0674265B2/ja not_active Expired - Lifetime
- 1990-08-01 NO NO90903389A patent/NO903389L/no unknown
- 1990-08-01 ZA ZA906050A patent/ZA906050B/xx unknown
- 1990-08-01 PT PT94879A patent/PT94879B/pt not_active IP Right Cessation
- 1990-08-01 IE IE278790A patent/IE67045B1/en not_active IP Right Cessation
-
1992
- 1992-07-14 AU AU19630/92A patent/AU641595B2/en not_active Expired - Fee Related
-
1995
- 1995-02-28 GR GR950400432T patent/GR3015227T3/el unknown
-
1998
- 1998-06-26 KR KR1019980024262A patent/KR0175639B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0415102A1 (en) | 1991-03-06 |
| IL95252A0 (en) | 1991-06-10 |
| NO903389D0 (no) | 1990-08-01 |
| KR910004599A (ko) | 1991-03-29 |
| US5006537A (en) | 1991-04-09 |
| NO903389L (no) | 1991-02-04 |
| AU641595B2 (en) | 1993-09-23 |
| GR3015227T3 (en) | 1995-05-31 |
| JPH03118377A (ja) | 1991-05-20 |
| IE67045B1 (en) | 1996-02-21 |
| ATE118001T1 (de) | 1995-02-15 |
| DK0415102T3 (da) | 1995-06-19 |
| DE69016530T2 (de) | 1995-07-06 |
| AU6000490A (en) | 1991-02-07 |
| KR0175639B1 (en) | 1999-10-01 |
| CA2022486A1 (en) | 1991-02-03 |
| AU1963092A (en) | 1992-10-01 |
| JPH0674265B2 (ja) | 1994-09-21 |
| DE69016530D1 (de) | 1995-03-16 |
| PT94879B (pt) | 1997-08-29 |
| PT94879A (pt) | 1991-04-18 |
| CA2022486C (en) | 2001-04-03 |
| ES2068293T3 (es) | 1995-04-16 |
| IE902787A1 (en) | 1991-02-27 |
| FI903819A0 (fi) | 1990-07-31 |
| US5053511A (en) | 1991-10-01 |
| AU628202B2 (en) | 1992-09-10 |
| KR0169108B1 (ko) | 1999-01-15 |
| NZ234725A (en) | 1992-12-23 |
| EP0415102B1 (en) | 1995-02-01 |
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| GR3026318T3 (en) | N-substituted-4-pyrimidinamines and -pyrimidindiamines, a process for their preparation and their use as medicaments | |
| IL95250A0 (en) | 1-(pyridinylamino-2-pyrrolidinones,a process for their preparation and their use as medicaments | |
| AU628201B2 (en) | 2,3-dihydro-1-(pyridinylamino)-indoles, a process for their preparation and their use as medicaments |