ZA899742B - Antiretroviral furan ketones - Google Patents

Antiretroviral furan ketones

Info

Publication number
ZA899742B
ZA899742B ZA899742A ZA899742A ZA899742B ZA 899742 B ZA899742 B ZA 899742B ZA 899742 A ZA899742 A ZA 899742A ZA 899742 A ZA899742 A ZA 899742A ZA 899742 B ZA899742 B ZA 899742B
Authority
ZA
South Africa
Prior art keywords
antiretroviral
furan
ketones
furan ketones
antiretroviral furan
Prior art date
Application number
ZA899742A
Other languages
English (en)
Inventor
Roger Alan Parker
Alan Parker Roger
Sai Prasad Sunkara
Prasad Sunkara Sai
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA899742B publication Critical patent/ZA899742B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58One oxygen atom, e.g. butenolide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/46Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA899742A 1988-12-21 1989-12-19 Antiretroviral furan ketones ZA899742B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28776288A 1988-12-21 1988-12-21

Publications (1)

Publication Number Publication Date
ZA899742B true ZA899742B (en) 1990-09-26

Family

ID=23104228

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA899742A ZA899742B (en) 1988-12-21 1989-12-19 Antiretroviral furan ketones

Country Status (15)

Country Link
EP (1) EP0374886A3 (no)
JP (1) JPH02221269A (no)
KR (1) KR900009620A (no)
CN (1) CN1043711A (no)
AU (1) AU621434B2 (no)
CA (1) CA2005991A1 (no)
DK (1) DK650089A (no)
FI (1) FI896134A0 (no)
HU (1) HUT52492A (no)
IL (1) IL92796A0 (no)
NO (1) NO895158L (no)
NZ (1) NZ231856A (no)
PH (1) PH26687A (no)
PT (1) PT92633A (no)
ZA (1) ZA899742B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU621435B2 (en) * 1988-12-21 1992-03-12 Merrell Dow Pharmaceuticals Inc. Antiretroviral aryloxy substituted furan ketones
US5665874A (en) * 1989-01-17 1997-09-09 John Hopkins University Cancer related antigen
US5759837A (en) * 1989-01-17 1998-06-02 John Hopkins University Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
US5759791A (en) * 1989-01-17 1998-06-02 The Johns Hopkins University Cancer related antigen
US5614551A (en) * 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
US5981575A (en) * 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass
CN100395241C (zh) * 2006-05-26 2008-06-18 中国科学院南海海洋研究所 一种降解呋喃二倍半萜角质海绵素及其制备方法和应用
CN101820757A (zh) 2007-06-01 2010-09-01 普林斯顿大学托管委员会 通过调节宿主细胞代谢途径治疗病毒感染
ES2481346B1 (es) * 2012-12-26 2015-05-08 Consejo Superior De Investigaciones Científicas (Csic) Procedimiento de obtención de moléculas orgánicas útiles como nuevos agentes surfactantes.
CN114163407B (zh) * 2020-09-11 2023-10-24 中国科学院宁波材料技术与工程研究所 抑制或杀灭微生物的呋喃环类成分、含其的制品及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1104574A (en) * 1976-12-20 1981-07-07 Roger A. Parker Antirhinovirus agents
FR2518999A1 (fr) * 1981-12-28 1983-07-01 Agrifurane Sa Procede de preparation de composes cetoniques en particulier de composes furanniques ou composes cetoniques a longues chaines, composes furanniques et composes cetoniques a longues chaines prepares par mise en oeuvre dudit procede
US4801698A (en) * 1986-08-15 1989-01-31 Warner-Lambert Company Process for preparing diaminopyrimido(4,5-d)pyrimidine glycoside and glycotide
AU621435B2 (en) * 1988-12-21 1992-03-12 Merrell Dow Pharmaceuticals Inc. Antiretroviral aryloxy substituted furan ketones

Also Published As

Publication number Publication date
JPH02221269A (ja) 1990-09-04
NO895158L (no) 1990-06-22
AU4693089A (en) 1990-06-28
DK650089A (da) 1990-06-22
AU621434B2 (en) 1992-03-12
IL92796A0 (en) 1990-09-17
CN1043711A (zh) 1990-07-11
EP0374886A2 (en) 1990-06-27
PT92633A (pt) 1990-06-29
HUT52492A (en) 1990-07-28
NO895158D0 (no) 1989-12-20
KR900009620A (ko) 1990-07-05
CA2005991A1 (en) 1990-06-21
HU896706D0 (en) 1990-02-28
PH26687A (en) 1992-09-15
FI896134A0 (fi) 1989-12-20
NZ231856A (en) 1991-05-28
DK650089D0 (da) 1989-12-20
EP0374886A3 (en) 1992-01-02

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