EP0374886A3 - Antiretroviral furan ketones - Google Patents

Antiretroviral furan ketones Download PDF

Info

Publication number
EP0374886A3
EP0374886A3 EP19890123559 EP89123559A EP0374886A3 EP 0374886 A3 EP0374886 A3 EP 0374886A3 EP 19890123559 EP19890123559 EP 19890123559 EP 89123559 A EP89123559 A EP 89123559A EP 0374886 A3 EP0374886 A3 EP 0374886A3
Authority
EP
European Patent Office
Prior art keywords
antiretroviral
furan
branched
straight
ketones
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19890123559
Other languages
German (de)
French (fr)
Other versions
EP0374886A2 (en
Inventor
Roger A. Parker
Sai P. Sunkara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of EP0374886A2 publication Critical patent/EP0374886A2/en
Publication of EP0374886A3 publication Critical patent/EP0374886A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/64—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Furan ketone derivatives thereof having antiretrovirus activity and effective in a method of treatment of a retrovirus infection, have the formula
EP19890123559 1988-12-21 1989-12-20 Antiretroviral furan ketones Ceased EP0374886A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28776288A 1988-12-21 1988-12-21
US287762 1988-12-21

Publications (2)

Publication Number Publication Date
EP0374886A2 EP0374886A2 (en) 1990-06-27
EP0374886A3 true EP0374886A3 (en) 1992-01-02

Family

ID=23104228

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19890123559 Ceased EP0374886A3 (en) 1988-12-21 1989-12-20 Antiretroviral furan ketones

Country Status (15)

Country Link
EP (1) EP0374886A3 (en)
JP (1) JPH02221269A (en)
KR (1) KR900009620A (en)
CN (1) CN1043711A (en)
AU (1) AU621434B2 (en)
CA (1) CA2005991A1 (en)
DK (1) DK650089A (en)
FI (1) FI896134A0 (en)
HU (1) HUT52492A (en)
IL (1) IL92796A0 (en)
NO (1) NO895158L (en)
NZ (1) NZ231856A (en)
PH (1) PH26687A (en)
PT (1) PT92633A (en)
ZA (1) ZA899742B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU621435B2 (en) * 1988-12-21 1992-03-12 Merrell Dow Pharmaceuticals Inc. Antiretroviral aryloxy substituted furan ketones
US5759837A (en) * 1989-01-17 1998-06-02 John Hopkins University Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
US5665874A (en) * 1989-01-17 1997-09-09 John Hopkins University Cancer related antigen
US5759791A (en) * 1989-01-17 1998-06-02 The Johns Hopkins University Cancer related antigen
US5614551A (en) * 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
US5981575A (en) * 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass
CN100395241C (en) * 2006-05-26 2008-06-18 中国科学院南海海洋研究所 Degradeable furan sesterterpenes keratinous spongistatin, and its preparing method and use
JP5616220B2 (en) 2007-06-01 2014-10-29 ザ トラスティーズ オブ プリンストン ユニバーシティ Treatment of viral infections by regulating host cell metabolic pathways
ES2481346B1 (en) * 2012-12-26 2015-05-08 Consejo Superior De Investigaciones Científicas (Csic) PROCEDURE FOR OBTAINING USEFUL ORGANIC MOLECULES AS NEW SURFACTING AGENTS.
CN114163407B (en) * 2020-09-11 2023-10-24 中国科学院宁波材料技术与工程研究所 Furan ring component for inhibiting or killing microorganism, product containing the same and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE862066A (en) * 1976-12-20 1978-04-14 Richardson Merrell Inc ANTI-RHINOVIRUS AGENTS AND PROCESS FOR THEIR PREPARATION
FR2518999A1 (en) * 1981-12-28 1983-07-01 Agrifurane Sa Heterocyclic ketone(s) prepn. - from heterocycle and acid with tri:fluoro:acetic anhydride and phosphoric catalyst
EP0257488A2 (en) * 1986-08-15 1988-03-02 Warner-Lambert Company Novel diaminopyrimido[4,5-d]pyrimidine glycoside and glycotide and process

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU621435B2 (en) * 1988-12-21 1992-03-12 Merrell Dow Pharmaceuticals Inc. Antiretroviral aryloxy substituted furan ketones

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE862066A (en) * 1976-12-20 1978-04-14 Richardson Merrell Inc ANTI-RHINOVIRUS AGENTS AND PROCESS FOR THEIR PREPARATION
FR2518999A1 (en) * 1981-12-28 1983-07-01 Agrifurane Sa Heterocyclic ketone(s) prepn. - from heterocycle and acid with tri:fluoro:acetic anhydride and phosphoric catalyst
EP0257488A2 (en) * 1986-08-15 1988-03-02 Warner-Lambert Company Novel diaminopyrimido[4,5-d]pyrimidine glycoside and glycotide and process

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANTIMICROBIAL AGENTS AND CHEMISTRY, vol. 16, no. 3, September 1979, pages 301-305; R.J. ASH et al.: "RMI 15,731 (1-[5-tetradecyloxy-2-fuanyl]-ethanone), a new antirhinovirus compound". *
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 27, no. 4, April 1985, pages 595-599, American Society for Microbiology; Y. NINOMIYA et al.: "Comparative studies on the modes of action of the antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731,4',6-dichloroflavan, and enviroxime". *
THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 18, suppl. B, October 1986, pages 11-18, The British Society for Antimicrobial Chemotherapy; H. ISHITSUKA et al.: "Molecular basis of drug resistance to new antirhinovirus agents". *

Also Published As

Publication number Publication date
DK650089A (en) 1990-06-22
HUT52492A (en) 1990-07-28
FI896134A0 (en) 1989-12-20
CA2005991A1 (en) 1990-06-21
KR900009620A (en) 1990-07-05
CN1043711A (en) 1990-07-11
PT92633A (en) 1990-06-29
EP0374886A2 (en) 1990-06-27
JPH02221269A (en) 1990-09-04
NZ231856A (en) 1991-05-28
ZA899742B (en) 1990-09-26
DK650089D0 (en) 1989-12-20
NO895158L (en) 1990-06-22
NO895158D0 (en) 1989-12-20
PH26687A (en) 1992-09-15
AU621434B2 (en) 1992-03-12
HU896706D0 (en) 1990-02-28
AU4693089A (en) 1990-06-28
IL92796A0 (en) 1990-09-17

Similar Documents

Publication Publication Date Title
EP0374886A3 (en) Antiretroviral furan ketones
FR2617041B1 (en) ORTHESIS OR PROSTHESIS FOR THE COORDINATION OF MOVEMENTS
BR9712488A (en) Remodeled human anti-hm 1.24 antibody
ATE83157T1 (en) PROSTHETIC DEVICES.
MC2272A1 (en) USE OF THE ACTIVE SUBSTANCE NAMED FLUPIRTINE TO COMBAT MUSCLE CONTRACTIONS
ATE82487T1 (en) FRACTURE STAY.
DE68904462D1 (en) 4-CHINOLINE CARBONIC ACID DERIVATIVES, USEABLE FOR TREATING SKIN AND MUCO EPITHELIAL TISSUE DISEASES.
IT1238825B (en) DEVICE FOR SURGICAL CORRECTION OF AMETROPIA.
EP0202654A3 (en) 5-carboxy-1,4-dihydropyrimidine derivatives
IT8221901A0 (en) HARDENING PHASE AND HARDENING PROCEDURE TO REDUCE LARGE STEEL SPROCKETS, HARDENING DEFORMATION DURING AS WELL AS SUPPORT BODY ADEQUATE FOR THIS PURPOSE.
IL92800A0 (en) Antiretroviral aryloxy substituted furan ketones
DE3880564D1 (en) MEDICINES FOR TREATING HEART INSUFFICIENCY.
IT1225262B (en) METHOD FOR THE AWARENESS OF SMALL ANIMALS TO VIRUS INFECTION OF HUMAN IMMUNODEFICIENCY (HIV)
MD950010A (en) Composition for removing or deactivation of toxic components from blood and other extracellular body liquids and methol for prepations theref
DE3889818D1 (en) Method for the determination of "soluble" fibrin.
DE3668338D1 (en) CONTINUOUS TREATMENT OF TENSIVE TISSUE.
SU1428362A1 (en) Method of plasty of tendons
DE3777709D1 (en) USE OF 3'AZIDO-3'DEOXYTHYMIDIN FOR PRODUCING A MEDICINAL PRODUCT FOR TREATING GARDIASIS.
SU719618A1 (en) Method of operative treatment of finger flexor tendons
ATE92545T1 (en) USE OF A GOLD BATH TO MAKE DENTAL PROSTHESES.
ATE98855T1 (en) IMPLANT TO REPLACE A TOOTH OR PART OF A BONE.
ATE88636T1 (en) USE OF A, B AND C PROSTAGLANDINS AND THEIR DERIVATIVES FOR THE TREATMENT OF EYE HYPERTENSION AND GLAUCOMA.
IT8919215A0 (en) DEVICE FOR THE SURGICAL TREATMENT OF AMETROPIA.
ES2002594A6 (en) Prevention of mineralisation of collagen-rich biological materials
DE3875647D1 (en) USE OF 2- (2-PHENYL-2- (2-PYRIDYL)) ETHYL-2-IMIDAZOLINE OR A SALT THEREOF TO PREPARE AN ANTIASTHMATIC.

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE

17P Request for examination filed

Effective date: 19901210

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE CH DE ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19921201

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 19930726