ZA899559B - Use of peptide isosteres as retroviral protease inhibitors - Google Patents

Use of peptide isosteres as retroviral protease inhibitors

Info

Publication number
ZA899559B
ZA899559B ZA899559A ZA899559A ZA899559B ZA 899559 B ZA899559 B ZA 899559B ZA 899559 A ZA899559 A ZA 899559A ZA 899559 A ZA899559 A ZA 899559A ZA 899559 B ZA899559 B ZA 899559B
Authority
ZA
South Africa
Prior art keywords
protease inhibitors
retroviral protease
peptide isosteres
isosteres
peptide
Prior art date
Application number
ZA899559A
Other languages
English (en)
Inventor
Alexander Faessler
Faessler Alexander
Ernst Hungerbuehler
Hungerbuehler Ernst
Johannes Roesel
Roesel Johannes
Heinrich Rueeger
Rueeger Heinrich
Peter Schneider
Schneider Peter
Jeanette Wood
Wood Jeanette
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of ZA899559B publication Critical patent/ZA899559B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/553—Renin inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
ZA899559A 1988-12-15 1989-12-14 Use of peptide isosteres as retroviral protease inhibitors ZA899559B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH464188 1988-12-15

Publications (1)

Publication Number Publication Date
ZA899559B true ZA899559B (en) 1990-08-29

Family

ID=4279922

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA899559A ZA899559B (en) 1988-12-15 1989-12-14 Use of peptide isosteres as retroviral protease inhibitors

Country Status (7)

Country Link
EP (1) EP0374097A3 (da)
JP (1) JPH02212434A (da)
AU (1) AU4678589A (da)
CA (1) CA2005337A1 (da)
DK (1) DK633189A (da)
IL (1) IL92671A0 (da)
ZA (1) ZA899559B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409927A (en) * 1992-04-01 1995-04-25 Ciba-Geigy Corporation Morpholin- and thiomorpholin-4-ylamides

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
DE4001236A1 (de) * 1990-01-18 1991-07-25 Bayer Ag Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren
CA2036397C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
CA2036413C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
CA2036398C (en) * 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
IL98260A0 (en) * 1990-06-01 1992-06-21 Ciba Geigy Ag Hiv protease inhibiting oligopeptides,process for their preparation and pharmaceutical compositions containing them
DE69221309T2 (de) 1991-10-11 1997-12-11 The Du Pont Merck Pharmaceutical Co., Wilmington, Del. Cyclische harnstoffe und analoga verwendbar als retrovirale proteasehemmer
AU3240493A (en) * 1991-12-12 1993-07-19 Schering Corporation Compounds and compositions for treating HIV infections
CA2091151A1 (en) * 1992-03-13 1993-09-14 Kwan Y. Hui Retroviral protease inhibitors
EP0641333B1 (en) * 1992-05-20 1996-08-14 G.D. Searle & Co. Method for making intermediates useful in synthesis of retroviral protease inhibitors
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
ATE172985T1 (de) * 1993-02-09 1998-11-15 Bayer Ag Sulfonamidaminomethylenderivate als immunsuppressiva
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
AU6491294A (en) * 1993-03-26 1994-10-24 Warner-Lambert Company Inhibitors of endothelin converting enzyme
DE4332395A1 (de) * 1993-09-23 1995-04-13 Horst Dr Lindhofer Inhibitoren zur Hemmung der zymogenähnlichen Freispaltung der HIV-1 Protease
DK0708085T3 (da) * 1994-10-19 2002-11-11 Novartis Ag Antivirale ethere af aspartatproteasesubstrat-isostere
CA2191924A1 (en) * 1995-12-05 1997-06-06 Kevin Felsenstein 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
US5703129A (en) * 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI843837A7 (fi) * 1983-02-07 1984-09-28 Ab Haessle Entsyymi-inhibiittorit.
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
BE1002213A5 (fr) * 1987-04-23 1990-10-16 Sandoz Sa Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409927A (en) * 1992-04-01 1995-04-25 Ciba-Geigy Corporation Morpholin- and thiomorpholin-4-ylamides

Also Published As

Publication number Publication date
JPH02212434A (ja) 1990-08-23
EP0374097A2 (de) 1990-06-20
DK633189A (da) 1990-06-16
DK633189D0 (da) 1989-12-14
IL92671A0 (en) 1990-09-17
CA2005337A1 (en) 1990-06-15
EP0374097A3 (de) 1991-06-12
AU4678589A (en) 1990-06-21

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