IL92671A0 - Pharmaceutical compositions containing peptide isosteres as retroviral protease inhibitors - Google Patents

Pharmaceutical compositions containing peptide isosteres as retroviral protease inhibitors

Info

Publication number
IL92671A0
IL92671A0 IL92671A IL9267189A IL92671A0 IL 92671 A0 IL92671 A0 IL 92671A0 IL 92671 A IL92671 A IL 92671A IL 9267189 A IL9267189 A IL 9267189A IL 92671 A0 IL92671 A0 IL 92671A0
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
protease inhibitors
containing peptide
retroviral protease
Prior art date
Application number
IL92671A
Other languages
English (en)
Original Assignee
Ciba Geigy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy filed Critical Ciba Geigy
Publication of IL92671A0 publication Critical patent/IL92671A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/553—Renin inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
IL92671A 1988-12-15 1989-12-13 Pharmaceutical compositions containing peptide isosteres as retroviral protease inhibitors IL92671A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH464188 1988-12-15

Publications (1)

Publication Number Publication Date
IL92671A0 true IL92671A0 (en) 1990-09-17

Family

ID=4279922

Family Applications (1)

Application Number Title Priority Date Filing Date
IL92671A IL92671A0 (en) 1988-12-15 1989-12-13 Pharmaceutical compositions containing peptide isosteres as retroviral protease inhibitors

Country Status (7)

Country Link
EP (1) EP0374097A3 (xx)
JP (1) JPH02212434A (xx)
AU (1) AU4678589A (xx)
CA (1) CA2005337A1 (xx)
DK (1) DK633189A (xx)
IL (1) IL92671A0 (xx)
ZA (1) ZA899559B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
DE4001236A1 (de) * 1990-01-18 1991-07-25 Bayer Ag Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren
CA2036397C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
CA2036398C (en) * 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
CA2036413C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
AU7732691A (en) * 1990-06-01 1991-12-05 Ciba-Geigy Ag Hiv protease inhibitors and processes for their preparation
BR9206623A (pt) 1991-10-11 1995-05-02 Du Pont Merck Pharma Uréias cíclicas e análogas úteis como inibidoras da protease retroviral
WO1993012138A1 (en) * 1991-12-12 1993-06-24 Schering Corporation Compounds and compositions for treating hiv infections
CA2091151A1 (en) * 1992-03-13 1993-09-14 Kwan Y. Hui Retroviral protease inhibitors
TW217410B (xx) * 1992-04-01 1993-12-11 Ciba Geigy
EP0641333B1 (en) * 1992-05-20 1996-08-14 G.D. Searle & Co. Method for making intermediates useful in synthesis of retroviral protease inhibitors
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
EP0610744B1 (en) * 1993-02-09 1998-11-04 Bayer Corporation Sulfonamide aminomethylene derivatives as immunosuppressants
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
WO1994022906A1 (en) * 1993-03-26 1994-10-13 Warner-Lambert Company Inhibitors of endothelin converting enzyme
DE4332395A1 (de) * 1993-09-23 1995-04-13 Horst Dr Lindhofer Inhibitoren zur Hemmung der zymogenähnlichen Freispaltung der HIV-1 Protease
ATE220661T1 (de) * 1994-10-19 2002-08-15 Novartis Erfind Verwalt Gmbh Antivirale ether von aspartat-protease-substrat- isosteren
CA2191924A1 (en) * 1995-12-05 1997-06-06 Kevin Felsenstein 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
US5703129A (en) * 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
FR2614533A1 (fr) * 1987-04-23 1988-11-04 Sandoz Sa Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments

Also Published As

Publication number Publication date
ZA899559B (en) 1990-08-29
EP0374097A3 (de) 1991-06-12
CA2005337A1 (en) 1990-06-15
DK633189D0 (da) 1989-12-14
AU4678589A (en) 1990-06-21
DK633189A (da) 1990-06-16
EP0374097A2 (de) 1990-06-20
JPH02212434A (ja) 1990-08-23

Similar Documents

Publication Publication Date Title
IL92671A0 (en) Pharmaceutical compositions containing peptide isosteres as retroviral protease inhibitors
GB2222770B (en) Pharmaceutical compositions containing cyclosporins
IL99163A0 (en) Inhibitors for serine proteases,their preparation and pharmaceutical compositions containing them
IL96691A0 (en) Hiv protease inhibitors and pharmaceutical compositions containing them
IL90218A0 (en) Retroviral protease inhibitors
IL86613A0 (en) Peptide boronic acid derivatives and compositions containing them for inhibiting trypsin-like proteases
IL72799A0 (en) Peptides and pharmaceutical compositions containing them
HUT38105A (en) Process for preparing new renine inhibitor peptides and pharmaceutical compositions containing such a peptide as active substance
EP0428849A3 (en) Retroviral protease inhibitors
GB8818447D0 (en) Tripeptides & pharmaceutical compositions containing them
GB2171103B (en) Novel peptides and peptide derivatives, their preparation and use and pharmaceutical compositions containing them
IL92672A0 (en) Retroviral protease inhibitors,their preparation and pharmaceutical compositions containing them
IL82645A0 (en) Pharmaceutical compositions containing polypeptides
IL110724A (en) Retroviral protease inhibitors and pharmaceutical compositions containing them
PT87535A (pt) Process for the preparation of novel anf peptide derivatives and of pharmaceutical compositions containing the same
NZ237185A (en) Hiv protease inhibitors containing amino acid units and pharmaceutical compositions thereof
IL74140A0 (en) Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidinecarboxamides and pharmaceutical compositions containing them
ZA894544B (en) Renin inhibiting isosteric peptide derivatives and of pharmaceutical compositions containing the same
GB8415467D0 (en) Peptides pharmaceutical compositions &c
IL89049A0 (en) Pharmaceutical composition containing 4-aroylimidazol-2-ones
IE894012L (en) Use of peptide isosteres as retroviral protease inhibitors
IL91350A0 (en) Phenylalkylthiophenes and related compounds and pharmaceutical compositions containing them
GB8816464D0 (en) Amino acid pharmaceutical compositions
GB8825323D0 (en) Peptide compounds processes for preparation thereof & pharmaceutical composition comprising same
GB8806193D0 (en) Peptide compounds processes for preparation thereof & pharmaceutical composition comprising same