AU4678589A - Use of peptide isosteres as retroviral protease inhibitors - Google Patents

Use of peptide isosteres as retroviral protease inhibitors

Info

Publication number
AU4678589A
AU4678589A AU46785/89A AU4678589A AU4678589A AU 4678589 A AU4678589 A AU 4678589A AU 46785/89 A AU46785/89 A AU 46785/89A AU 4678589 A AU4678589 A AU 4678589A AU 4678589 A AU4678589 A AU 4678589A
Authority
AU
Australia
Prior art keywords
protease inhibitors
retroviral protease
peptide isosteres
isosteres
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU46785/89A
Inventor
Not Given Name
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of AU4678589A publication Critical patent/AU4678589A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/553—Renin inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU46785/89A 1988-12-15 1989-12-14 Use of peptide isosteres as retroviral protease inhibitors Abandoned AU4678589A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH464188 1988-12-15
CH4641/88 1988-12-15

Publications (1)

Publication Number Publication Date
AU4678589A true AU4678589A (en) 1990-06-21

Family

ID=4279922

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46785/89A Abandoned AU4678589A (en) 1988-12-15 1989-12-14 Use of peptide isosteres as retroviral protease inhibitors

Country Status (7)

Country Link
EP (1) EP0374097A3 (en)
JP (1) JPH02212434A (en)
AU (1) AU4678589A (en)
CA (1) CA2005337A1 (en)
DK (1) DK633189A (en)
IL (1) IL92671A0 (en)
ZA (1) ZA899559B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
DE4001236A1 (en) * 1990-01-18 1991-07-25 Bayer Ag New oligopeptide(s) contg. 2-amino-2-methyl propionic acid residue - are antiviral agents for human or veterinary therapy including treatment of AIDS and ARC
CA2036413C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
CA2036398C (en) * 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
CA2036397C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
IL98260A0 (en) * 1990-06-01 1992-06-21 Ciba Geigy Ag Hiv protease inhibiting oligopeptides,process for their preparation and pharmaceutical compositions containing them
ATE216371T1 (en) 1991-10-11 2002-05-15 Du Pont Pharm Co CYCLIC UREAS AND ANALOGUES USABLE AS RETROVIRAL PROTEASE INHIBITORS
AU3240493A (en) * 1991-12-12 1993-07-19 Schering Corporation Compounds and compositions for treating HIV infections
CA2091151A1 (en) * 1992-03-13 1993-09-14 Kwan Y. Hui Retroviral protease inhibitors
TW217410B (en) * 1992-04-01 1993-12-11 Ciba Geigy
CA2131182C (en) * 1992-05-20 2005-04-26 John S. Ng Method for making intermediates useful in synthesis of retroviral protease inhibitors
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
EP0610744B1 (en) * 1993-02-09 1998-11-04 Bayer Corporation Sulfonamide aminomethylene derivatives as immunosuppressants
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
WO1994022906A1 (en) * 1993-03-26 1994-10-13 Warner-Lambert Company Inhibitors of endothelin converting enzyme
DE4332395A1 (en) * 1993-09-23 1995-04-13 Horst Dr Lindhofer Inhibitors for the zymogen-like liberation cleavage of HIV-1 protease
PT708085E (en) * 1994-10-19 2002-11-29 Novartis Ag PROTEASE ASPARTATE SUBSTRATE ISOSTERATE ETERIS ANTERIORS
CA2191924A1 (en) * 1995-12-05 1997-06-06 Kevin Felsenstein 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
US5703129A (en) * 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
FR2614533A1 (en) * 1987-04-23 1988-11-04 Sandoz Sa NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5760036A (en) * 1992-07-20 1998-06-02 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5776933A (en) * 1992-07-20 1998-07-07 E. R. Squibb & Sons, Inc. Method of inhibiting protease

Also Published As

Publication number Publication date
CA2005337A1 (en) 1990-06-15
IL92671A0 (en) 1990-09-17
EP0374097A2 (en) 1990-06-20
ZA899559B (en) 1990-08-29
DK633189D0 (en) 1989-12-14
EP0374097A3 (en) 1991-06-12
JPH02212434A (en) 1990-08-23
DK633189A (en) 1990-06-16

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