DK633189A - USE OF PEPTIDISOSTERS AS RETROVIRAL PROTEASE INHIBITORS - Google Patents

USE OF PEPTIDISOSTERS AS RETROVIRAL PROTEASE INHIBITORS Download PDF

Info

Publication number
DK633189A
DK633189A DK633189A DK633189A DK633189A DK 633189 A DK633189 A DK 633189A DK 633189 A DK633189 A DK 633189A DK 633189 A DK633189 A DK 633189A DK 633189 A DK633189 A DK 633189A
Authority
DK
Denmark
Prior art keywords
peptidisosters
protease inhibitors
retroviral protease
retroviral
inhibitors
Prior art date
Application number
DK633189A
Other languages
Danish (da)
Other versions
DK633189D0 (en
Inventor
Alexander Faessler
Ernst Hungerbuehler
Johannes Roesel
Heinrich Rueeger
Peter Schneider
Jeanette Wood
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK633189D0 publication Critical patent/DK633189D0/en
Publication of DK633189A publication Critical patent/DK633189A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/553—Renin inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK633189A 1988-12-15 1989-12-14 USE OF PEPTIDISOSTERS AS RETROVIRAL PROTEASE INHIBITORS DK633189A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH464188 1988-12-15

Publications (2)

Publication Number Publication Date
DK633189D0 DK633189D0 (en) 1989-12-14
DK633189A true DK633189A (en) 1990-06-16

Family

ID=4279922

Family Applications (1)

Application Number Title Priority Date Filing Date
DK633189A DK633189A (en) 1988-12-15 1989-12-14 USE OF PEPTIDISOSTERS AS RETROVIRAL PROTEASE INHIBITORS

Country Status (7)

Country Link
EP (1) EP0374097A3 (en)
JP (1) JPH02212434A (en)
AU (1) AU4678589A (en)
CA (1) CA2005337A1 (en)
DK (1) DK633189A (en)
IL (1) IL92671A0 (en)
ZA (1) ZA899559B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1340682C (en) * 1989-07-07 1999-07-27 Pierre Lavallee Antiviral peptides having a 2-oxoalkyl amino acid side chain
DE4001236A1 (en) * 1990-01-18 1991-07-25 Bayer Ag New oligopeptide(s) contg. 2-amino-2-methyl propionic acid residue - are antiviral agents for human or veterinary therapy including treatment of AIDS and ARC
CA2036413C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors
CA2036397C (en) * 1990-02-23 2000-12-12 Paul Cates Anderson Hiv protease inhibitors containing derived amino acid units
CA2036398C (en) * 1990-02-23 2000-06-13 Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee Hiv protease inhibiting agents
IL98260A0 (en) * 1990-06-01 1992-06-21 Ciba Geigy Ag Hiv protease inhibiting oligopeptides,process for their preparation and pharmaceutical compositions containing them
WO1993023388A1 (en) * 1992-05-20 1993-11-25 G.D. Searle & Co. Method for making intermediates useful in synthesis of retroviral protease inhibitors
BR9206623A (en) 1991-10-11 1995-05-02 Du Pont Merck Pharma Cyclic and similar ureas useful as retroviral protease inhibitors
AU3240493A (en) * 1991-12-12 1993-07-19 Schering Corporation Compounds and compositions for treating HIV infections
CA2091151A1 (en) * 1992-03-13 1993-09-14 Kwan Y. Hui Retroviral protease inhibitors
TW217410B (en) * 1992-04-01 1993-12-11 Ciba Geigy
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
DE69414279T2 (en) * 1993-02-09 1999-04-08 Bayer Corp., Pittsburgh, Pa. Sulfonamide aminomethylene derivatives as immunosuppressants
US5686469A (en) * 1993-02-09 1997-11-11 Miles Inc. Aminomethylene derivaties as immunosuppressants
EP0610745A3 (en) * 1993-02-09 1994-09-28 Miles Inc Novel aminomethylene derivatives as immunosuppressants.
WO1994022906A1 (en) * 1993-03-26 1994-10-13 Warner-Lambert Company Inhibitors of endothelin converting enzyme
DE4332395A1 (en) * 1993-09-23 1995-04-13 Horst Dr Lindhofer Inhibitors for the zymogen-like liberation cleavage of HIV-1 protease
EP0708085B1 (en) * 1994-10-19 2002-07-17 Novartis AG Antiviral ethers of aspartate protease substrate isosteres
CA2191924A1 (en) * 1995-12-05 1997-06-06 Kevin Felsenstein 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
US5703129A (en) * 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0316965A3 (en) * 1983-02-07 1989-08-09 Aktiebolaget Hässle Enzyme inhibitors
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
FR2614533A1 (en) * 1987-04-23 1988-11-04 Sandoz Sa NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS

Also Published As

Publication number Publication date
EP0374097A3 (en) 1991-06-12
ZA899559B (en) 1990-08-29
CA2005337A1 (en) 1990-06-15
IL92671A0 (en) 1990-09-17
AU4678589A (en) 1990-06-21
JPH02212434A (en) 1990-08-23
DK633189D0 (en) 1989-12-14
EP0374097A2 (en) 1990-06-20

Similar Documents

Publication Publication Date Title
DK633189D0 (en) USE OF PEPTIDISOSTERS AS RETROVIRAL PROTEASE INHIBITORS
DK674387D0 (en) protease inhibitors
MX9100119A (en) RETROVIRAL PROTEASE INHIBITORS
ATE241602T1 (en) SULFONAMIDE INHIBITERS OF HIV-ASPARTYL PROTEASE
KR960701010A (en) Inhibitors of HIV reverse transcriptase
DK486686A (en) USE OF BENZAMIDE DERIVATIVES
DK363887D0 (en) USE OF BROMCRUPTIN
FI935644A (en) Retroviral protease inhibitors
DK633289D0 (en) RETROVIRAL PROTEASE INHIBITORS
FI865196A (en) RALIN INHIBITOR OF HALOSTAT SUBSTITUTES.
DK226989D0 (en) PROCEDURE FOR PLASMA CLEANING OF SURFACES
DK273089D0 (en) USE OF PEPTIDE DERIVATIVES
DK4687D0 (en) USE OF ESTER COMPOUNDS AS TEMPORATED MICROBICID
DK301585A (en) USE OF ACTINONIN AS IMMUNPOTENTIATOR
DK316289D0 (en) USE OF DIFLUORMETHYL-THIADIAZOLYL OXYEDIC ACID AMAMIDS AS SELECTIVE HERBICIDES
DK80990D0 (en) SULPHONYL DERIVATIVES OF THIEN-TRIAZOL-DIAZEPIN
DK104389A (en) USE OF IMIDAZOLD DERIVATIVES
DK130390D0 (en) PREPARATION OF PLASMINOGEN ACTIVATOR EXPRESSED
DK369686D0 (en) PROCEDURE FOR CLEANING Tissue PLASMINOGEN ACTIVATOR
DK562289A (en) USE OF SOMATO STATINES
NO171701C (en) USE OF N-DECYLTIOETYLAMINE AS MICROBIOCID
DK602288D0 (en) INTERMEDIATES FOR THE PREPARATION OF HALOGENED PROTEASE INHIBITORS
DK101686D0 (en) USE OF (-) - 15-DEOXYSPERGUALIN AS IMMUNOSUPPRESSIVE AGENT
DK130992D0 (en) PROCEDURE FOR THE PREPARATION OF ANGIOTENXINE-CREATING ENZYMINE INHIBITORS
DK93288D0 (en) USE OF THE MUELER INHIBITOR AS A CONTRACEPTIVE AGENT

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
AHS Application shelved for other reasons than non-payment