IL110724A - Retroviral protease inhibitors and pharmaceutical compositions containing them - Google Patents

Retroviral protease inhibitors and pharmaceutical compositions containing them

Info

Publication number
IL110724A
IL110724A IL11072494A IL11072494A IL110724A IL 110724 A IL110724 A IL 110724A IL 11072494 A IL11072494 A IL 11072494A IL 11072494 A IL11072494 A IL 11072494A IL 110724 A IL110724 A IL 110724A
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
protease inhibitors
retroviral protease
retroviral
Prior art date
Application number
IL11072494A
Other versions
IL110724A0 (en
Original Assignee
Searle & Co
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/253,531 external-priority patent/US5750648A/en
Application filed by Searle & Co, Monsanto Co filed Critical Searle & Co
Publication of IL110724A0 publication Critical patent/IL110724A0/en
Publication of IL110724A publication Critical patent/IL110724A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL11072494A 1993-08-20 1994-08-19 Retroviral protease inhibitors and pharmaceutical compositions containing them IL110724A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10978793A 1993-08-20 1993-08-20
US08/253,531 US5750648A (en) 1993-08-20 1994-06-03 Retroviral protease inhibitors and combinations thereof

Publications (2)

Publication Number Publication Date
IL110724A0 IL110724A0 (en) 1994-11-11
IL110724A true IL110724A (en) 1999-08-17

Family

ID=26807360

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11072494A IL110724A (en) 1993-08-20 1994-08-19 Retroviral protease inhibitors and pharmaceutical compositions containing them

Country Status (3)

Country Link
AU (1) AU7518694A (en)
IL (1) IL110724A (en)
WO (1) WO1995006061A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232333B1 (en) 1996-11-21 2001-05-15 Abbott Laboratories Pharmaceutical composition
US20030100532A1 (en) 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
CN100382804C (en) * 1997-02-14 2008-04-23 G·D·瑟尔公司 Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
CA2309321A1 (en) 1997-11-10 1999-05-20 G.D. Searle & Co. Use of alkylated iminosugars to treat multidrug resistance
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
AU762125B2 (en) 1998-02-12 2003-06-19 G.D. Searle & Co. Use of (N)-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
WO2001008672A2 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
AU3595500A (en) 1999-02-12 2000-08-29 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
DE60038899D1 (en) 2000-01-19 2008-06-26 Abbott Lab HIV PROTEASE INHIBITORS
JP5448854B2 (en) 2007-03-12 2014-03-19 ウェルズ ファーゴ バンク ナショナル アソシエイション Oligomer-protease inhibitor complex
US9095620B2 (en) 2008-03-12 2015-08-04 Nektar Therapeutics Reagents
US20120108501A1 (en) 2009-06-12 2012-05-03 Nektar Therapeutics Protease Inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2059293T3 (en) * 1990-11-19 1998-12-16 Monsanto Co RETROVIRAL PROTEASE INHIBITORS.
AU4253193A (en) * 1992-05-20 1993-12-13 G.D. Searle & Co. Urea-containing hydroxyethylamine compounds as retroviral protease inhibitors

Also Published As

Publication number Publication date
IL110724A0 (en) 1994-11-11
WO1995006061A1 (en) 1995-03-02
AU7518694A (en) 1995-03-21

Similar Documents

Publication Publication Date Title
IL109503A0 (en) Hiv protease inhibitors and pharmaceutical compositions containing them
HUP9900964A3 (en) Protease inhibitors and pharmaceutical compositions containing these compounds
IL111785A0 (en) Dp-iv inhibitors and pharmaceutical compositions containing them
IL96691A0 (en) Hiv protease inhibitors and pharmaceutical compositions containing them
IL111221A0 (en) N-alkyl-n- arylpyrimidinamine derivatives and pharmaceutical compositions containing them
IL110752A0 (en) Pharmaceutical composition for an hiv protease inhibitor
IL109867A0 (en) alpha-heteroaryloxymethyl ketones as interleukin -1beta protease inhibitors and pharmaceutical compositions containing them
IL105218A0 (en) Hexanones and pharmaceutical compositions containing them
IL105223A0 (en) Cyclohexane-ylidenes and pharmaceutical compositions containing them
PL313871A1 (en) Inhibitors of hiv protease
ZA947305B (en) Pharmaceutical compositions and usages
IL114626A (en) 6-membered nitrogen-containing heteroaryl-oxazolidinones and pharmaceutical compositions containing them
IL99163A0 (en) Inhibitors for serine proteases,their preparation and pharmaceutical compositions containing them
IL110743A0 (en) Heterocyclic compounds and pharmaceutical compositions containing the same
IL110988A0 (en) 4-arylamino-benzopyran derivatives and pharmaceutical compositions containing the same
IL120311A0 (en) Serine protease inhibitors and pharmaceutical compositions containing them
HUP9902256A3 (en) Amidino protease inhibitors and pharmaceutical compositions containing them
IL120310A0 (en) Serine protease inhibitors and pharmaceutical compositions containing them
HUP0002951A3 (en) Bis-aminomethylcarbonyl compounds as protease inhibitors and pharmaceutical compositions containing them
IL106098A0 (en) Heteroarylnaphthalenes and pharmaceutical compositions containing them
PH30121A (en) Retroviral protease inhibitors
IL92672A0 (en) Retroviral protease inhibitors,their preparation and pharmaceutical compositions containing them
IL110724A (en) Retroviral protease inhibitors and pharmaceutical compositions containing them
NZ237733A (en) Neutral metalloprotease inhibitors and pharmaceutical compositions
NZ237185A (en) Hiv protease inhibitors containing amino acid units and pharmaceutical compositions thereof

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees