ZA899559B - Use of peptide isosteres as retroviral protease inhibitors - Google Patents
Use of peptide isosteres as retroviral protease inhibitorsInfo
- Publication number
- ZA899559B ZA899559B ZA899559A ZA899559A ZA899559B ZA 899559 B ZA899559 B ZA 899559B ZA 899559 A ZA899559 A ZA 899559A ZA 899559 A ZA899559 A ZA 899559A ZA 899559 B ZA899559 B ZA 899559B
- Authority
- ZA
- South Africa
- Prior art keywords
- protease inhibitors
- retroviral protease
- peptide isosteres
- isosteres
- peptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/553—Renin inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH464188 | 1988-12-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA899559B true ZA899559B (en) | 1990-08-29 |
Family
ID=4279922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA899559A ZA899559B (en) | 1988-12-15 | 1989-12-14 | Use of peptide isosteres as retroviral protease inhibitors |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0374097A3 (xx) |
JP (1) | JPH02212434A (xx) |
AU (1) | AU4678589A (xx) |
CA (1) | CA2005337A1 (xx) |
DK (1) | DK633189A (xx) |
IL (1) | IL92671A0 (xx) |
ZA (1) | ZA899559B (xx) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5409927A (en) * | 1992-04-01 | 1995-04-25 | Ciba-Geigy Corporation | Morpholin- and thiomorpholin-4-ylamides |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1340682C (en) * | 1989-07-07 | 1999-07-27 | Pierre Lavallee | Antiviral peptides having a 2-oxoalkyl amino acid side chain |
DE4001236A1 (de) * | 1990-01-18 | 1991-07-25 | Bayer Ag | Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren |
CA2036397C (en) * | 1990-02-23 | 2000-12-12 | Paul Cates Anderson | Hiv protease inhibitors containing derived amino acid units |
CA2036398C (en) * | 1990-02-23 | 2000-06-13 | Boehringer Ingelheim (Canada) Ltd./ Boehringer Ingelheim (Canada) Ltee | Hiv protease inhibiting agents |
CA2036413C (en) * | 1990-02-23 | 2000-12-12 | Paul Cates Anderson | Hiv protease inhibitors |
AU7732691A (en) * | 1990-06-01 | 1991-12-05 | Ciba-Geigy Ag | Hiv protease inhibitors and processes for their preparation |
BR9206623A (pt) | 1991-10-11 | 1995-05-02 | Du Pont Merck Pharma | Uréias cíclicas e análogas úteis como inibidoras da protease retroviral |
WO1993012138A1 (en) * | 1991-12-12 | 1993-06-24 | Schering Corporation | Compounds and compositions for treating hiv infections |
CA2091151A1 (en) * | 1992-03-13 | 1993-09-14 | Kwan Y. Hui | Retroviral protease inhibitors |
EP0641333B1 (en) * | 1992-05-20 | 1996-08-14 | G.D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
US5385918A (en) * | 1993-02-09 | 1995-01-31 | Miles Inc. | Aminomethylene-peptides as immunosuppressants |
EP0610744B1 (en) * | 1993-02-09 | 1998-11-04 | Bayer Corporation | Sulfonamide aminomethylene derivatives as immunosuppressants |
US5686469A (en) * | 1993-02-09 | 1997-11-11 | Miles Inc. | Aminomethylene derivaties as immunosuppressants |
EP0610745A3 (en) * | 1993-02-09 | 1994-09-28 | Miles Inc | Novel aminomethylene derivatives as immunosuppressants. |
WO1994022906A1 (en) * | 1993-03-26 | 1994-10-13 | Warner-Lambert Company | Inhibitors of endothelin converting enzyme |
DE4332395A1 (de) * | 1993-09-23 | 1995-04-13 | Horst Dr Lindhofer | Inhibitoren zur Hemmung der zymogenähnlichen Freispaltung der HIV-1 Protease |
ATE220661T1 (de) * | 1994-10-19 | 2002-08-15 | Novartis Erfind Verwalt Gmbh | Antivirale ether von aspartat-protease-substrat- isosteren |
CA2191924A1 (en) * | 1995-12-05 | 1997-06-06 | Kevin Felsenstein | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production |
US5703129A (en) * | 1996-09-30 | 1997-12-30 | Bristol-Myers Squibb Company | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU573735B2 (en) * | 1983-02-07 | 1988-06-23 | Aktiebolaget Hassle | Peptide analogue enzyme inhibitors |
US4727060A (en) * | 1984-11-13 | 1988-02-23 | Ciba-Geigy Corporation | Novel 5-amino-4-hydroxyvaleryl derivatives |
FR2614533A1 (fr) * | 1987-04-23 | 1988-11-04 | Sandoz Sa | Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments |
-
1989
- 1989-12-06 EP EP19890810922 patent/EP0374097A3/de not_active Withdrawn
- 1989-12-13 CA CA002005337A patent/CA2005337A1/en not_active Abandoned
- 1989-12-13 IL IL92671A patent/IL92671A0/xx unknown
- 1989-12-14 DK DK633189A patent/DK633189A/da not_active Application Discontinuation
- 1989-12-14 ZA ZA899559A patent/ZA899559B/xx unknown
- 1989-12-14 AU AU46785/89A patent/AU4678589A/en not_active Abandoned
- 1989-12-15 JP JP1324110A patent/JPH02212434A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5409927A (en) * | 1992-04-01 | 1995-04-25 | Ciba-Geigy Corporation | Morpholin- and thiomorpholin-4-ylamides |
Also Published As
Publication number | Publication date |
---|---|
EP0374097A3 (de) | 1991-06-12 |
CA2005337A1 (en) | 1990-06-15 |
IL92671A0 (en) | 1990-09-17 |
DK633189D0 (da) | 1989-12-14 |
AU4678589A (en) | 1990-06-21 |
DK633189A (da) | 1990-06-16 |
EP0374097A2 (de) | 1990-06-20 |
JPH02212434A (ja) | 1990-08-23 |
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