ZA898720B - Hydroxy-1,2,3,4-tetrahydroaminoacridines,a process for their preparation and their use as medicaments - Google Patents

Hydroxy-1,2,3,4-tetrahydroaminoacridines,a process for their preparation and their use as medicaments

Info

Publication number
ZA898720B
ZA898720B ZA898720A ZA898720A ZA898720B ZA 898720 B ZA898720 B ZA 898720B ZA 898720 A ZA898720 A ZA 898720A ZA 898720 A ZA898720 A ZA 898720A ZA 898720 B ZA898720 B ZA 898720B
Authority
ZA
South Africa
Prior art keywords
loweralkyl
hydroxy
preparation
hydrogen
arylloweralkyl
Prior art date
Application number
ZA898720A
Other languages
English (en)
Inventor
Gregory M Shutske
M Shutske Gregory
John D Tomer
D Tomer John
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of ZA898720B publication Critical patent/ZA898720B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C07D219/12—Amino-alkylamino radicals attached in position 9

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)
ZA898720A 1988-11-16 1989-11-15 Hydroxy-1,2,3,4-tetrahydroaminoacridines,a process for their preparation and their use as medicaments ZA898720B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27178888A 1988-11-16 1988-11-16

Publications (1)

Publication Number Publication Date
ZA898720B true ZA898720B (en) 1990-08-29

Family

ID=23037088

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA898720A ZA898720B (en) 1988-11-16 1989-11-15 Hydroxy-1,2,3,4-tetrahydroaminoacridines,a process for their preparation and their use as medicaments

Country Status (15)

Country Link
EP (1) EP0369388B1 (no)
KR (1) KR0156241B1 (no)
AT (1) ATE89553T1 (no)
CA (1) CA2003023C (no)
DE (1) DE68906647T2 (no)
DK (1) DK168290B1 (no)
ES (1) ES2054987T3 (no)
FI (1) FI90417C (no)
HU (2) HU208674B (no)
IE (1) IE63038B1 (no)
IL (1) IL92307A0 (no)
NO (1) NO894547L (no)
NZ (1) NZ231376A (no)
PT (1) PT92319B (no)
ZA (1) ZA898720B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200462B (no) * 1990-09-27 1993-02-21 Hoechst Roussel Pharma
GB2264707A (en) * 1991-06-18 1993-09-08 Roger Michael Marchbanks Acridine derivatives for treating alzheimer's disease
US5422350A (en) * 1992-09-10 1995-06-06 Warner-Lambert Company Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
US5466696A (en) * 1992-09-10 1995-11-14 Warner Lambert Company Tacrine and cytochrome P450 oxidase inhibitors and methods of use
WO2019207604A1 (en) * 2018-04-25 2019-10-31 Rajiv Gandhi Centre For Biotechnology Tacrine derivatives targeting nmda receptor, acetylcholine esterase, butyryl choline and beta secretase activity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3582995D1 (de) * 1984-10-25 1991-07-04 Hoechst Roussel Pharma 9-amino-1,2,3,4-tetrahydroacridin-1-ol und verwandte verbindungen, verfahren zu ihrer herstellung und verwendung als arzneimittel.
NZ223875A (en) * 1987-03-17 1991-01-29 Hoechst Roussel Pharma 9-aminotetrahydroacridines and related homologues and pharmaceutical compositions

Also Published As

Publication number Publication date
ATE89553T1 (de) 1993-06-15
IE63038B1 (en) 1995-03-22
PT92319B (pt) 1995-08-09
HU208674B (en) 1993-12-28
EP0369388A1 (en) 1990-05-23
NO894547D0 (no) 1989-11-15
HU895931D0 (en) 1990-02-28
FI90417B (fi) 1993-10-29
IL92307A0 (en) 1990-07-26
NO894547L (no) 1990-05-18
EP0369388B1 (en) 1993-05-19
CA2003023A1 (en) 1990-05-16
KR0156241B1 (ko) 1998-11-16
KR900007809A (ko) 1990-06-02
NZ231376A (en) 1992-05-26
HUT53087A (en) 1990-09-28
FI90417C (fi) 1994-02-10
DE68906647D1 (de) 1993-06-24
CA2003023C (en) 2001-05-29
HU211701A9 (en) 1995-12-28
DK571989D0 (da) 1989-11-15
DK571989A (da) 1990-05-17
FI895416A0 (fi) 1989-11-14
DE68906647T2 (de) 1993-10-07
PT92319A (pt) 1990-05-31
DK168290B1 (da) 1994-03-07
ES2054987T3 (es) 1994-08-16
IE893659L (en) 1990-05-16

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