ZA892342B - Method for radiolabeling proteins - Google Patents

Method for radiolabeling proteins

Info

Publication number
ZA892342B
ZA892342B ZA892342A ZA892342A ZA892342B ZA 892342 B ZA892342 B ZA 892342B ZA 892342 A ZA892342 A ZA 892342A ZA 892342 A ZA892342 A ZA 892342A ZA 892342 B ZA892342 B ZA 892342B
Authority
ZA
South Africa
Prior art keywords
radiometal
radiolabeling proteins
binds tightly
sulfhydryl groups
pendant
Prior art date
Application number
ZA892342A
Other languages
English (en)
Inventor
Dan Shochat
Shochat Dan
Hans J Hansen
J Hansen Hans
Robert Sundoro-Wu
Sundoro-Wu Robert
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Publication of ZA892342B publication Critical patent/ZA892342B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Arrangements For Transmission Of Measured Signals (AREA)
ZA892342A 1988-04-01 1989-03-30 Method for radiolabeling proteins ZA892342B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/176,421 US5061641A (en) 1988-04-01 1988-04-01 Method for radiolabeling proteins

Publications (1)

Publication Number Publication Date
ZA892342B true ZA892342B (en) 1989-12-27

Family

ID=22644297

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA892342A ZA892342B (en) 1988-04-01 1989-03-30 Method for radiolabeling proteins

Country Status (15)

Country Link
US (2) US5061641A (fr)
EP (1) EP0336678B1 (fr)
JP (1) JP2521168B2 (fr)
KR (1) KR0151105B1 (fr)
AT (1) ATE130288T1 (fr)
AU (1) AU617826B2 (fr)
CA (1) CA1340167C (fr)
DE (1) DE68924795T2 (fr)
DK (1) DK235390A (fr)
ES (1) ES2078907T3 (fr)
FI (1) FI904788A0 (fr)
IE (1) IE70588B1 (fr)
IL (1) IL89795A (fr)
WO (1) WO1989009405A1 (fr)
ZA (1) ZA892342B (fr)

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US5541297A (en) * 1988-04-01 1996-07-30 Immunomedics, Inc. Therapeutic conjugates of toxins and drugs
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US5208007A (en) * 1988-11-22 1993-05-04 Board Of Regents Of The University Of Oklahoma Isotopic tracer composition and method for making and using same
ES2125854T3 (es) * 1989-08-09 1999-03-16 Rhomed Inc Radiomarcado directo de anticuerpos y otras proteinas con tecnetio o renio.
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US5700444A (en) * 1992-02-20 1997-12-23 Rhomed Incorporated Chemotactic peptide pharmaceutical applications
US5078985A (en) * 1989-08-09 1992-01-07 Rhomed, Incorporated Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction
US5346687A (en) * 1989-08-09 1994-09-13 Rhomed Incorporated Direct radiolabeling of antibody against stage specific embryonic antigen for diagnostic imaging
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
WO1991002547A1 (fr) * 1989-08-24 1991-03-07 Australian Nuclear Science & Technology Organisation Anticorps radiomarques d'imagerie
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US5011676A (en) * 1990-03-27 1991-04-30 Thomas Jefferson University Method to directly radiolabel antibodies for diagnostic imaging and therapy
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US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5317091A (en) * 1991-02-27 1994-05-31 Akzo N.V. Technetium-99m labeling of proteins
KR100238558B1 (ko) * 1991-02-27 2000-02-01 에프.쥐.엠.헤르만스 단백질의 테크네튬-99m 표지화
US5783170A (en) * 1991-11-27 1998-07-21 Diatide, Inc. Peptide-metal chelate conjugates
US5643549A (en) * 1992-02-20 1997-07-01 Rhomed Incorporated Leukostimulatory agent for in vivo leukocyte tagging
US5403573A (en) * 1992-04-23 1995-04-04 The Curators Of The University Of Missouri Radiolabeled protein composition and method for radiation synovectomy
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
US5263047A (en) * 1992-07-02 1993-11-16 Motorola, Inc. Multiple cavity tuning of a transmitter output in a communication system
CA2137561C (fr) * 1992-07-06 2001-10-23 Thomas R. Sykes Photoactivation de proteines en vue de leur conjugaison
US5951964A (en) * 1993-06-04 1999-09-14 Diatide, Inc. Technetium-99m labeled peptides for imaging
AU2194695A (en) * 1994-03-28 1995-10-17 Regents Of The University Of California, The Method for preparing radionuclide-labeled chelating agent-ligand complexes
US5541289A (en) * 1994-03-30 1996-07-30 Washington University Phosphine containing amino acids and peptides and methods of preparing and using same
CA2190727C (fr) * 1994-05-19 2006-07-18 Sudhakar Kasina Ligands d'atomes donneurs d'azote et de soufre pontes et substitues par amines aromatiques, utilises en imagerie
US5746996A (en) * 1994-06-03 1998-05-05 Immunomedics, Inc. Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
US5670132A (en) * 1994-09-20 1997-09-23 Immunomedics, Inc. Modified radioantibody fragments for reduced renal uptake
WO1997001520A1 (fr) * 1995-06-28 1997-01-16 E.I. Du Pont De Nemours And Company Composition et procede de stabilisation de composes organiques radiomarques
US6080384A (en) * 1997-03-25 2000-06-27 American Biogenetic Sciences, Inc. Methods for radionuclide-labeling of biomolecules and kits utilizing the same
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
US5961955A (en) * 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
US6623655B1 (en) 2000-04-24 2003-09-23 Sigma-Aldrich Co. Metal chelating compositions
US20060083684A1 (en) * 2002-02-12 2006-04-20 Walton Paul H Method of radio-labelling biomolecules
EP1419786A1 (fr) * 2002-11-13 2004-05-19 Bracco Imaging S.p.A. Méthode pour sélectivement et quantitativement fonctionnaliser des fragments Fab d'immunoglobuline, molécules conjuguées utilisant ceux-ci et ses compositions
US20050027110A1 (en) * 2003-07-24 2005-02-03 Michael Russell Drug delivery in the nervous system
US20060057062A1 (en) * 2004-09-10 2006-03-16 Trotter Dinko G Compositions and methods useful in pretargeted imaging
US20060134647A1 (en) * 2004-12-17 2006-06-22 Sylwia Karwowska Method for elimination of false reactivities in immunoassay for Hepatitis A virus
EP1700608A1 (fr) 2005-03-10 2006-09-13 Schering AG Agents chélatants comportant une chaîne latérale stabilisante pour des conjugués radiomarqués
CA2604840A1 (fr) * 2005-04-18 2006-10-26 Xtl Biopharmaceuticals Ltd. Preparations d'anticorps anti-hepatite b (vhb) stabilises
US8895002B2 (en) 2007-04-09 2014-11-25 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
WO2011110490A1 (fr) 2010-03-09 2011-09-15 Bayer Pharma Aktiengesellschaft Procédé pour la production de fragments d'anticorps scfv marqués radioactivement, kits et compositions
CN103328038A (zh) 2010-12-01 2013-09-25 史拜诺莫度雷森公司 向神经解剖结构直接递送药剂
WO2012129237A2 (fr) 2011-03-20 2012-09-27 Trustees Of Boston University Agent thérapeutique utilisable en vue du traitement de l'emphysème et de la maladie pulmonaire obstructive chronique
KR20160029731A (ko) 2013-03-12 2016-03-15 더 제너럴 하스피탈 코포레이션 변형된 뮐러관 억제 물질(mis) 단백질 및 질환 치료를 위한 그 용도
DK3079712T3 (da) 2013-12-11 2022-04-25 Massachusetts Gen Hospital Anvendelse af müllersk inhiberende substans- (mis) proteiner til kontraception og ovariereservebevarelse
US11479793B2 (en) 2015-07-15 2022-10-25 Rutgers, The State University Of New Jersey Nuclease-independent targeted gene editing platform and uses thereof
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CN110520163A (zh) 2017-01-05 2019-11-29 新泽西鲁特格斯州立大学 独立于dna双链断裂的靶向基因编辑平台及其用途
JP7384815B2 (ja) 2018-03-22 2023-11-21 ザ チルドレンズ メディカル センター コーポレーション 肺の修復に関する方法および組成物
US20230235315A1 (en) 2020-07-10 2023-07-27 Horizon Discovery Limited Method for producing genetically modified cells
EP4274893A1 (fr) 2021-01-05 2023-11-15 Horizon Discovery Limited Procédé de production de cellules génétiquement modifiées
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US5328679A (en) * 1988-04-01 1994-07-12 Immunomedics, Inc. Methods for technetium/rhenium labeling of proteins
ES2125854T3 (es) * 1989-08-09 1999-03-16 Rhomed Inc Radiomarcado directo de anticuerpos y otras proteinas con tecnetio o renio.
US5078985A (en) * 1989-08-09 1992-01-07 Rhomed, Incorporated Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction

Also Published As

Publication number Publication date
KR900700886A (ko) 1990-08-17
KR0151105B1 (ko) 1999-05-15
CA1340167C (fr) 1998-12-08
AU617826B2 (en) 1991-12-05
JP2521168B2 (ja) 1996-07-31
ATE130288T1 (de) 1995-12-15
IE70588B1 (en) 1996-12-11
IL89795A0 (en) 1989-09-28
DK235390D0 (da) 1990-09-28
JPH03504858A (ja) 1991-10-24
IL89795A (en) 1994-08-26
WO1989009405A1 (fr) 1989-10-05
DE68924795D1 (de) 1995-12-21
EP0336678A3 (en) 1990-08-29
EP0336678B1 (fr) 1995-11-15
IE891034L (en) 1989-10-01
AU3691489A (en) 1989-10-16
ES2078907T3 (es) 1996-01-01
US5061641A (en) 1991-10-29
DE68924795T2 (de) 1996-05-30
FI904788A0 (fi) 1990-09-28
US5514363A (en) 1996-05-07
EP0336678A2 (fr) 1989-10-11
DK235390A (da) 1990-09-28

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