ZA892342B - Method for radiolabeling proteins - Google Patents

Method for radiolabeling proteins

Info

Publication number
ZA892342B
ZA892342B ZA892342A ZA892342A ZA892342B ZA 892342 B ZA892342 B ZA 892342B ZA 892342 A ZA892342 A ZA 892342A ZA 892342 A ZA892342 A ZA 892342A ZA 892342 B ZA892342 B ZA 892342B
Authority
ZA
South Africa
Prior art keywords
radiometal
radiolabeling proteins
binds tightly
sulfhydryl groups
pendant
Prior art date
Application number
ZA892342A
Other languages
English (en)
Inventor
Dan Shochat
Shochat Dan
Hans J Hansen
J Hansen Hans
Robert Sundoro-Wu
Sundoro-Wu Robert
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Publication of ZA892342B publication Critical patent/ZA892342B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1048—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell determinant being a carcino embryonic antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Arrangements For Transmission Of Measured Signals (AREA)
ZA892342A 1988-04-01 1989-03-30 Method for radiolabeling proteins ZA892342B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/176,421 US5061641A (en) 1988-04-01 1988-04-01 Method for radiolabeling proteins

Publications (1)

Publication Number Publication Date
ZA892342B true ZA892342B (en) 1989-12-27

Family

ID=22644297

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA892342A ZA892342B (en) 1988-04-01 1989-03-30 Method for radiolabeling proteins

Country Status (15)

Country Link
US (2) US5061641A (de)
EP (1) EP0336678B1 (de)
JP (1) JP2521168B2 (de)
KR (1) KR0151105B1 (de)
AT (1) ATE130288T1 (de)
AU (1) AU617826B2 (de)
CA (1) CA1340167C (de)
DE (1) DE68924795T2 (de)
DK (1) DK235390A (de)
ES (1) ES2078907T3 (de)
FI (1) FI904788A0 (de)
IE (1) IE70588B1 (de)
IL (1) IL89795A (de)
WO (1) WO1989009405A1 (de)
ZA (1) ZA892342B (de)

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US5317091A (en) * 1991-02-27 1994-05-31 Akzo N.V. Technetium-99m labeling of proteins
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US5403573A (en) * 1992-04-23 1995-04-04 The Curators Of The University Of Missouri Radiolabeled protein composition and method for radiation synovectomy
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
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EP0649532B1 (de) 1992-07-06 1997-11-12 Biomira, Inc. Photoaktivierung von proteinen zu konjugationszwecken
US5951964A (en) * 1993-06-04 1999-09-14 Diatide, Inc. Technetium-99m labeled peptides for imaging
AU2194695A (en) * 1994-03-28 1995-10-17 Regents Of The University Of California, The Method for preparing radionuclide-labeled chelating agent-ligand complexes
US5541289A (en) * 1994-03-30 1996-07-30 Washington University Phosphine containing amino acids and peptides and methods of preparing and using same
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same
US5746996A (en) * 1994-06-03 1998-05-05 Immunomedics, Inc. Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
US5670132A (en) * 1994-09-20 1997-09-23 Immunomedics, Inc. Modified radioantibody fragments for reduced renal uptake
WO1997001520A1 (en) * 1995-06-28 1997-01-16 E.I. Du Pont De Nemours And Company Composition and method for stabilizing radiolabeled organic compounds
US6080384A (en) * 1997-03-25 2000-06-27 American Biogenetic Sciences, Inc. Methods for radionuclide-labeling of biomolecules and kits utilizing the same
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US5961955A (en) 1997-06-03 1999-10-05 Coulter Pharmaceutical, Inc. Radioprotectant for peptides labeled with radioisotope
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WO2003068270A1 (en) * 2002-02-12 2003-08-21 Vistatec York Limited Method of radio-labelling biomolecules
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US20060057062A1 (en) * 2004-09-10 2006-03-16 Trotter Dinko G Compositions and methods useful in pretargeted imaging
US20060134647A1 (en) * 2004-12-17 2006-06-22 Sylwia Karwowska Method for elimination of false reactivities in immunoassay for Hepatitis A virus
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KR101280273B1 (ko) * 2005-04-18 2013-07-15 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 안정화된 항-ｂ형 간염 바이러스 (ｈｂｖ) 항체 제형
WO2008124768A1 (en) 2007-04-09 2008-10-16 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
WO2011110490A1 (en) 2010-03-09 2011-09-15 Bayer Pharma Aktiengesellschaft Process for the production of radioactively labelled scfv antibody fragments, kits and compositions
EP2646107A2 (de) 2010-12-01 2013-10-09 Spinal Modulation Inc. Wirkstofffreisetzungssysteme für selektive nervenmodulation
US9585930B2 (en) 2011-03-20 2017-03-07 Trustees Of Boston University Therapeutic agent for emphysema and COPD
DK2968470T3 (da) 2013-03-12 2021-02-01 Massachusetts Gen Hospital Modificeret müllersk inhiberende substans (mis)-proteiner og anvendelser deraf til behandlingen af sygdomme
US11135269B2 (en) 2013-12-11 2021-10-05 The General Hospital Corporation Use of mullerian inhibiting substance (MIS) proteins for contraception and ovarian reserve preservation
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WO2018044812A2 (en) 2016-08-29 2018-03-08 Fred Hutchinson Cancer Research Center Chelating platform for delivery of radionuclides
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Also Published As

Publication number Publication date
US5514363A (en) 1996-05-07
EP0336678A2 (de) 1989-10-11
CA1340167C (en) 1998-12-08
DE68924795D1 (de) 1995-12-21
US5061641A (en) 1991-10-29
EP0336678A3 (en) 1990-08-29
JPH03504858A (ja) 1991-10-24
DK235390D0 (da) 1990-09-28
IL89795A0 (en) 1989-09-28
IE70588B1 (en) 1996-12-11
ATE130288T1 (de) 1995-12-15
DK235390A (da) 1990-09-28
AU617826B2 (en) 1991-12-05
KR900700886A (ko) 1990-08-17
DE68924795T2 (de) 1996-05-30
IE891034L (en) 1989-10-01
EP0336678B1 (de) 1995-11-15
ES2078907T3 (es) 1996-01-01
JP2521168B2 (ja) 1996-07-31
FI904788A0 (fi) 1990-09-28
KR0151105B1 (ko) 1999-05-15
AU3691489A (en) 1989-10-16
IL89795A (en) 1994-08-26
WO1989009405A1 (en) 1989-10-05

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