ES2098382T3 - Procedimiento para la preparacion de una sustancia organoespecifica marcada con tecnecio-99m. - Google Patents

Procedimiento para la preparacion de una sustancia organoespecifica marcada con tecnecio-99m.

Info

Publication number
ES2098382T3
ES2098382T3 ES92101708T ES92101708T ES2098382T3 ES 2098382 T3 ES2098382 T3 ES 2098382T3 ES 92101708 T ES92101708 T ES 92101708T ES 92101708 T ES92101708 T ES 92101708T ES 2098382 T3 ES2098382 T3 ES 2098382T3
Authority
ES
Spain
Prior art keywords
preparation
tecnetio
specific substance
procedure
substance marked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92101708T
Other languages
English (en)
Inventor
Ludwig Dr Kuhlmann
Anton Mayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
CIS Bio International SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CIS Bio International SA filed Critical CIS Bio International SA
Application granted granted Critical
Publication of ES2098382T3 publication Critical patent/ES2098382T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

LA INVENCION SE REFIERE A UN PROCESO PARA LA FABRICACION DE UNA SUSTANCIA ORGANICA ESPECIFICA MARCADA CON TECNECIO-99M, EN LA QUE NINGUN COMPUESTO TC-99M NO DESEADO SE ENCUENTRA LIGADO A ANTICUERPOS. ESTO SE CONSIGUE DE TAL MODO QUE LA FORMACION DEL COMPLEJO NECESARIO PARA MEDIO DE REDUCCION, SE UTILIZA EN CANTIDADES ESTEQUIOMETRICAS EN UN MEDIO DE REDUCCION RELACIONADO CON EL PROCESO.
ES92101708T 1991-02-05 1992-02-03 Procedimiento para la preparacion de una sustancia organoespecifica marcada con tecnecio-99m. Expired - Lifetime ES2098382T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4103370 1991-02-05

Publications (1)

Publication Number Publication Date
ES2098382T3 true ES2098382T3 (es) 1997-05-01

Family

ID=6424382

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92101708T Expired - Lifetime ES2098382T3 (es) 1991-02-05 1992-02-03 Procedimiento para la preparacion de una sustancia organoespecifica marcada con tecnecio-99m.

Country Status (9)

Country Link
US (2) US5863517A (es)
EP (1) EP0498333B1 (es)
JP (1) JP3549115B2 (es)
AT (1) ATE147637T1 (es)
DE (1) DE59207867D1 (es)
ES (1) ES2098382T3 (es)
FI (1) FI920459A (es)
IE (1) IE920359A1 (es)
NO (1) NO920461L (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4578425B2 (ja) * 2006-03-20 2010-11-10 行政院原子能委員會核能研究所 テクネチウム−９９ｍ過テクネチウム酸溶液の濃縮装置及びその方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3987157A (en) * 1974-08-29 1976-10-19 Union Carbide Corporation Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation
US4293537A (en) * 1978-09-05 1981-10-06 Wong Dennis W Novel chemical method of labeling proteins with 99m Tc-Technetium at physiological condition
US4424200A (en) * 1979-05-14 1984-01-03 Nuc Med Inc. Method for radiolabeling proteins with technetium-99m
US4311688A (en) * 1979-10-29 1982-01-19 Serono Laboratories Inc. Composition and method for cancer detection in humans
DE3237573A1 (de) * 1982-10-09 1984-04-12 Hoechst Ag, 6230 Frankfurt Technetium-99m-tri- und tetraphosphonate zur szintigraphischen dastellung res-haltiger organe und der lymphgefaesse und verfahren zu deren herstellung
US4652440A (en) * 1984-05-03 1987-03-24 Paik Chang H Method of stably radiolabeling antibodies with technetium and rhenium
US5175343A (en) * 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US4877868A (en) * 1986-03-12 1989-10-31 Neorx Corporation Radionuclide antibody coupling
US5164175A (en) * 1986-12-10 1992-11-17 Hoechst Aktiengesellschaft Diagnostic aid containing an organ-specific substance labeled with technetium-99m
DE3728599A1 (de) * 1986-12-10 1988-06-23 Hoechst Ag Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz
JPH02504387A (ja) * 1987-04-02 1990-12-13 セントカー・カーデイオバスキユラー・イメージング・パートナーズ・エルピー 金属イオンで抗体を標識付けする方法
US5053493A (en) * 1987-04-02 1991-10-01 Centocor Cardiovascular Imaging Partners, L.P. Method for labeling antibodies with a metal ion
US5021556A (en) * 1987-07-22 1991-06-04 Neorx Corporation Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides
DE3728600A1 (de) * 1987-08-27 1989-03-09 Hoechst Ag Verfahren zur markierung von substanzen mit technetium oder rhenium
EP0401302B1 (en) * 1988-02-09 1995-06-28 Mallinckrodt, Inc. Method of preparing a metal-radionuclide-labelled protein
US5128119A (en) * 1989-06-12 1992-07-07 Immunomedics, Inc. Methods for technetium/rhenium labeling of f(ab1)2 fragments
US5061641A (en) * 1988-04-01 1991-10-29 Immunomedics, Inc. Method for radiolabeling proteins
US5102990A (en) * 1989-08-09 1992-04-07 Rhomed Incorporated Direct radiolabeling of antibodies and other proteins with technetium or rhenium
US5078985A (en) * 1989-08-09 1992-01-07 Rhomed, Incorporated Radiolabeling antibodies and other proteins with technetium or rhenium by regulated reduction
CA1340250C (en) * 1989-09-18 1998-12-15 Hans J. Hansen Method for rapidly radiolabeling monovalent antibody fragments with technetium
US5011676A (en) * 1990-03-27 1991-04-30 Thomas Jefferson University Method to directly radiolabel antibodies for diagnostic imaging and therapy

Also Published As

Publication number Publication date
ATE147637T1 (de) 1997-02-15
JPH0585944A (ja) 1993-04-06
DE59207867D1 (de) 1997-02-27
EP0498333A2 (de) 1992-08-12
NO920461L (no) 1992-08-06
NO920461D0 (no) 1992-02-04
IE920359A1 (en) 1992-08-12
FI920459A (fi) 1992-08-06
JP3549115B2 (ja) 2004-08-04
EP0498333A3 (en) 1992-11-19
FI920459A0 (fi) 1992-02-03
US6090366A (en) 2000-07-18
US5863517A (en) 1999-01-26
EP0498333B1 (de) 1997-01-15

Similar Documents

Publication Publication Date Title
BR8203771A (pt) Processo para preparacao de um composto e composicoes detergentes contendo o mesmo
DE3686931D1 (de) Monoklonale antikoerper, die determinanten gram-negativer bakterien binden.
FI925270A0 (fi) Farmaceutiska preparat foer oral anvaendning samt foerfarande foer deras framstaellning
MX167182B (es) Compuestos de imidazol y composicion biocida que los comprende, para controlar organismos dañinos
EP1378525A3 (en) Humanized antibodies that bind to the antigen bound by antibody NR-LU-13 and their use in pretargeting methods
ES2111031T3 (es) Uso de preparaciones que contienen anticuerpos para la inmunosupresion.
IN173187B (es)
SE8000074L (sv) Kontrastmedel
BR9205032A (pt) Composicao,metodo para estabilizacao de um material organico e composto
BR8108413A (pt) Processo organico,de uma fase,para a preparacao de um composto halocarbonilbis(triorganofosforo)rodio;processo para preparar um composto hidretocarboniltris(triorganofosforo)rodio;processo para preparar hidretocarboniltris(trifenilfosfica)rodio
DK407987A (da) Apolipoprotein b-specifikke monoklonale antistoffer og hybridomer, som producerer disse antistoffer
DE3771885D1 (de) Durch strahlung haertbare zusammensetzung.
HUP0001477A2 (hu) Kalcitonin receptorhoz kötődő peptidek
BR9102321A (pt) Composicao,metodo de estabilizar um material organico,composto
ATE67507T1 (de) Immunotoxine, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
JPS5758695A (en) Biologically atractive compound labeled by dichlorotriazinyl aminofluoresein
AR228364A1 (es) Compuesto de carbamoil-fenil-sulfamato,composicion que lo contiene,procedimiento para su preparacion y compuesto intermedio empleado
ES2098382T3 (es) Procedimiento para la preparacion de una sustancia organoespecifica marcada con tecnecio-99m.
ES2114547T3 (es) Anticuerpos monoclonales contra el virus de la hepatitis c.
SE8300486L (sv) Rengoringskomposition
DE69105541D1 (de) Methyl-2,6-cyclohexandiamin enthaltende Epoxydharzzusammensetzungen.
ATE41927T1 (de) Phenylalkylamine - bioregulatoren.
ES545018A0 (es) Procedimiento de preparar agentes de fluoracion de compuestos organicos.
DK150083D0 (da) Fremgangsmade til frembringelse af koncentreret biologisk isaer aktiveret slam
YU17890A (sh) Tekoc, algicidno ucinkovit pripravek

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 498333

Country of ref document: ES