ZA891389B - L-amino-3-acylquinoline derivatives their use as inhibitors of gastric secretion - Google Patents
L-amino-3-acylquinoline derivatives their use as inhibitors of gastric secretionInfo
- Publication number
- ZA891389B ZA891389B ZA891389A ZA891389A ZA891389B ZA 891389 B ZA891389 B ZA 891389B ZA 891389 A ZA891389 A ZA 891389A ZA 891389 A ZA891389 A ZA 891389A ZA 891389 B ZA891389 B ZA 891389B
- Authority
- ZA
- South Africa
- Prior art keywords
- 6alkyl
- amino
- inhibitors
- 6alkoxy
- hydrogen
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002496 gastric effect Effects 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, hydroxy Chemical group 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888804443A GB8804443D0 (en) | 1988-02-25 | 1988-02-25 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA891389B true ZA891389B (en) | 1990-10-31 |
Family
ID=10632375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA891389A ZA891389B (en) | 1988-02-25 | 1989-02-23 | L-amino-3-acylquinoline derivatives their use as inhibitors of gastric secretion |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5143920A (fr) |
| EP (1) | EP0342775B1 (fr) |
| JP (1) | JPH02503316A (fr) |
| KR (1) | KR900700458A (fr) |
| CN (1) | CN1035663A (fr) |
| AT (1) | ATE94535T1 (fr) |
| AU (1) | AU3181789A (fr) |
| DE (1) | DE68909107T2 (fr) |
| DK (1) | DK528789A (fr) |
| FI (1) | FI895046A0 (fr) |
| GB (1) | GB8804443D0 (fr) |
| HU (1) | HU891462D0 (fr) |
| PT (1) | PT89788B (fr) |
| WO (1) | WO1989008105A1 (fr) |
| ZA (1) | ZA891389B (fr) |
| ZW (1) | ZW1889A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8804444D0 (en) * | 1988-02-25 | 1988-03-23 | Smithkline Beckman Intercredit | Compounds |
| CA2011086A1 (fr) * | 1989-03-17 | 1990-09-17 | Karl-Heinz Geiss | 2-alkyl-4-arylmethylaminoquinolines, leur utilisation et medicaments les contenant |
| GB8918265D0 (en) * | 1989-08-10 | 1989-09-20 | Smithkline Beckman Intercredit | Compounds |
| KR920701162A (ko) * | 1990-03-28 | 1992-08-11 | 오츠카 아끼히코 | 퀴놀린 유도체, 당해 유도체를 함유하는 항궤양제 및 당해 유도체의 제조방법 |
| FR2680510B1 (fr) * | 1991-08-20 | 1995-06-23 | Roussel Uclaf | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| FR2672596B1 (fr) * | 1991-02-07 | 1995-07-13 | Roussel Uclaf | Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant. |
| MX9200299A (es) * | 1991-02-07 | 1992-12-01 | Roussel Uclaf | Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen. |
| GB9127252D0 (en) * | 1991-12-23 | 1992-02-19 | Boots Co Plc | Therapeutic agents |
| US5362743A (en) * | 1993-03-09 | 1994-11-08 | Pfizer Inc. | Aminoquinoline derivatives |
| US5556863A (en) * | 1993-06-11 | 1996-09-17 | Astra Aktiebolag | Compound for gastric acid secretion inhibition |
| IS4164A (is) * | 1993-06-11 | 1994-12-12 | Ab Astra | Efnasambönd sem hindra flæði magasýru |
| US5650415A (en) * | 1995-06-07 | 1997-07-22 | Sugen, Inc. | Quinoline compounds |
| JP4537582B2 (ja) | 1998-09-29 | 2010-09-01 | アメリカン・サイアナミド・カンパニー | プロテインチロシンキナーゼインヒビターとしての置換３−シアノキノリン |
| JP2005536462A (ja) * | 2002-04-30 | 2005-12-02 | ユン ジン ファーマスーチカル インダストリーズ カンパニー リミテッド | カスパーゼ−３阻害剤としてのキノリン誘導体、この製造方法及びこれを含む薬剤学的組成物 |
| FR2873695A1 (fr) * | 2004-07-30 | 2006-02-03 | Palumed Sa | Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien |
| US20210177827A1 (en) * | 2017-10-25 | 2021-06-17 | Children`S Medical Center Corporation | Papd5 inhibitors and methods of use thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2652398A (en) * | 1949-11-17 | 1953-09-15 | Endo Products Inc | N-substituted-2-amino (methyl) quinolines |
| US3391146A (en) * | 1964-11-10 | 1968-07-02 | Bristol Myers Co | Nu-substituted carbamates and thiocarbamates of 2-quinolinemethanols |
| US3470186A (en) * | 1967-06-02 | 1969-09-30 | American Cyanamid Co | Substituted 4-anilino-3-quinolinecarboxylic acids and esters |
| CA942748A (en) * | 1970-09-18 | 1974-02-26 | Venkatachala L. Narayanan | 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds |
| US4343804A (en) * | 1979-03-26 | 1982-08-10 | A. H. Robins Company, Inc. | 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds |
| US4789678A (en) * | 1986-08-25 | 1988-12-06 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds |
| GB8621425D0 (en) * | 1986-09-05 | 1986-10-15 | Smith Kline French Lab | Compounds |
-
1988
- 1988-02-25 GB GB888804443A patent/GB8804443D0/en active Pending
-
1989
- 1989-02-20 ZW ZW18/89A patent/ZW1889A1/xx unknown
- 1989-02-20 JP JP1502449A patent/JPH02503316A/ja active Pending
- 1989-02-20 HU HU891462A patent/HU891462D0/hu unknown
- 1989-02-20 AU AU31817/89A patent/AU3181789A/en not_active Abandoned
- 1989-02-20 WO PCT/EP1989/000173 patent/WO1989008105A1/fr active Application Filing
- 1989-02-22 PT PT89788A patent/PT89788B/pt not_active IP Right Cessation
- 1989-02-23 AT AT89301802T patent/ATE94535T1/de not_active IP Right Cessation
- 1989-02-23 EP EP89301802A patent/EP0342775B1/fr not_active Expired - Lifetime
- 1989-02-23 ZA ZA891389A patent/ZA891389B/xx unknown
- 1989-02-23 DE DE89301802T patent/DE68909107T2/de not_active Expired - Fee Related
- 1989-02-23 US US07/314,684 patent/US5143920A/en not_active Expired - Fee Related
- 1989-02-24 CN CN89100928A patent/CN1035663A/zh active Pending
- 1989-10-24 KR KR1019890701952A patent/KR900700458A/ko not_active Application Discontinuation
- 1989-10-24 DK DK528789A patent/DK528789A/da not_active Application Discontinuation
- 1989-10-24 FI FI895046A patent/FI895046A0/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT89788A (pt) | 1989-10-04 |
| JPH02503316A (ja) | 1990-10-11 |
| ZW1889A1 (en) | 1989-09-13 |
| PT89788B (pt) | 1994-05-31 |
| US5143920A (en) | 1992-09-01 |
| GB8804443D0 (en) | 1988-03-23 |
| CN1035663A (zh) | 1989-09-20 |
| HU891462D0 (en) | 1990-01-28 |
| DK528789D0 (da) | 1989-10-24 |
| EP0342775A1 (fr) | 1989-11-23 |
| DK528789A (da) | 1989-10-24 |
| EP0342775B1 (fr) | 1993-09-15 |
| KR900700458A (ko) | 1990-08-13 |
| DE68909107D1 (de) | 1993-10-21 |
| AU3181789A (en) | 1989-09-22 |
| FI895046A0 (fi) | 1989-10-24 |
| DE68909107T2 (de) | 1994-02-17 |
| ATE94535T1 (de) | 1993-10-15 |
| WO1989008105A1 (fr) | 1989-09-08 |
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