DK528789A - 4-amino-3-acylquinolinderivater og deres anvendelse som inhibitorer af mavesyresekretion - Google Patents

4-amino-3-acylquinolinderivater og deres anvendelse som inhibitorer af mavesyresekretion

Info

Publication number
DK528789A
DK528789A DK528789A DK528789A DK528789A DK 528789 A DK528789 A DK 528789A DK 528789 A DK528789 A DK 528789A DK 528789 A DK528789 A DK 528789A DK 528789 A DK528789 A DK 528789A
Authority
DK
Denmark
Prior art keywords
amino
6alkyl
inhibitors
6alkoxy
hydrogen
Prior art date
Application number
DK528789A
Other languages
English (en)
Other versions
DK528789D0 (da
Inventor
Robert John Ife
Thomas Henry Brown
Colin Andrew Leach
Original Assignee
Smithkline Beckman Intercredit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Intercredit filed Critical Smithkline Beckman Intercredit
Publication of DK528789D0 publication Critical patent/DK528789D0/da
Publication of DK528789A publication Critical patent/DK528789A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK528789A 1988-02-25 1989-10-24 4-amino-3-acylquinolinderivater og deres anvendelse som inhibitorer af mavesyresekretion DK528789A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888804443A GB8804443D0 (en) 1988-02-25 1988-02-25 Compounds
PCT/EP1989/000173 WO1989008105A1 (en) 1988-02-25 1989-02-20 4-amino-3-acylquinoline derivatives and their use as inhibitors of gastric secretion

Publications (2)

Publication Number Publication Date
DK528789D0 DK528789D0 (da) 1989-10-24
DK528789A true DK528789A (da) 1989-10-24

Family

ID=10632375

Family Applications (1)

Application Number Title Priority Date Filing Date
DK528789A DK528789A (da) 1988-02-25 1989-10-24 4-amino-3-acylquinolinderivater og deres anvendelse som inhibitorer af mavesyresekretion

Country Status (16)

Country Link
US (1) US5143920A (da)
EP (1) EP0342775B1 (da)
JP (1) JPH02503316A (da)
KR (1) KR900700458A (da)
CN (1) CN1035663A (da)
AT (1) ATE94535T1 (da)
AU (1) AU3181789A (da)
DE (1) DE68909107T2 (da)
DK (1) DK528789A (da)
FI (1) FI895046A0 (da)
GB (1) GB8804443D0 (da)
HU (1) HU891462D0 (da)
PT (1) PT89788B (da)
WO (1) WO1989008105A1 (da)
ZA (1) ZA891389B (da)
ZW (1) ZW1889A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
WO1991014677A1 (fr) * 1990-03-28 1991-10-03 Otsuka Pharmaceutical Co., Ltd. Derive de quinoline, medicament anti-ulcereux contenant ce derive et production de ce derive
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
FR2672596B1 (fr) * 1991-02-07 1995-07-13 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2680510B1 (fr) * 1991-08-20 1995-06-23 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
GB9127252D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US5362743A (en) * 1993-03-09 1994-11-08 Pfizer Inc. Aminoquinoline derivatives
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
US5650415A (en) * 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds
AU6159499A (en) 1998-09-29 2000-04-17 Wyeth Holdings Corporation Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors
EP1499593A4 (en) * 2002-04-30 2006-02-01 Yungjin Pharmacautical Co Ltd CHINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
FR2873695A1 (fr) * 2004-07-30 2006-02-03 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien
US20210177827A1 (en) * 2017-10-25 2021-06-17 Children`S Medical Center Corporation Papd5 inhibitors and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2652398A (en) * 1949-11-17 1953-09-15 Endo Products Inc N-substituted-2-amino (methyl) quinolines
US3391146A (en) * 1964-11-10 1968-07-02 Bristol Myers Co Nu-substituted carbamates and thiocarbamates of 2-quinolinemethanols
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
CA942748A (en) * 1970-09-18 1974-02-26 Venkatachala L. Narayanan 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds
US4343804A (en) * 1979-03-26 1982-08-10 A. H. Robins Company, Inc. 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds

Also Published As

Publication number Publication date
EP0342775A1 (en) 1989-11-23
ZW1889A1 (en) 1989-09-13
ZA891389B (en) 1990-10-31
ATE94535T1 (de) 1993-10-15
GB8804443D0 (en) 1988-03-23
DE68909107T2 (de) 1994-02-17
PT89788A (pt) 1989-10-04
WO1989008105A1 (en) 1989-09-08
AU3181789A (en) 1989-09-22
HU891462D0 (en) 1990-01-28
PT89788B (pt) 1994-05-31
US5143920A (en) 1992-09-01
EP0342775B1 (en) 1993-09-15
CN1035663A (zh) 1989-09-20
DE68909107D1 (de) 1993-10-21
DK528789D0 (da) 1989-10-24
FI895046A0 (fi) 1989-10-24
KR900700458A (ko) 1990-08-13
JPH02503316A (ja) 1990-10-11

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Legal Events

Date Code Title Description
AHB Application shelved due to non-payment