DE68909107D1 - 4-Amino-3-acylchinolin-Derivate und ihre Verwendung als Inhibitoren der Magensekretion. - Google Patents

4-Amino-3-acylchinolin-Derivate und ihre Verwendung als Inhibitoren der Magensekretion.

Info

Publication number
DE68909107D1
DE68909107D1 DE89301802T DE68909107T DE68909107D1 DE 68909107 D1 DE68909107 D1 DE 68909107D1 DE 89301802 T DE89301802 T DE 89301802T DE 68909107 T DE68909107 T DE 68909107T DE 68909107 D1 DE68909107 D1 DE 68909107D1
Authority
DE
Germany
Prior art keywords
6alkyl
amino
inhibitors
6alkoxy
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89301802T
Other languages
English (en)
Other versions
DE68909107T2 (de
Inventor
Robert John Ife
Colin Andrew Leach
Thomas Henry Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Intercredit BV
Original Assignee
SmithKline Beecham Intercredit BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Intercredit BV filed Critical SmithKline Beecham Intercredit BV
Publication of DE68909107D1 publication Critical patent/DE68909107D1/de
Application granted granted Critical
Publication of DE68909107T2 publication Critical patent/DE68909107T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
DE89301802T 1988-02-25 1989-02-23 4-Amino-3-acylchinolin-Derivate und ihre Verwendung als Inhibitoren der Magensekretion. Expired - Fee Related DE68909107T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888804443A GB8804443D0 (en) 1988-02-25 1988-02-25 Compounds

Publications (2)

Publication Number Publication Date
DE68909107D1 true DE68909107D1 (de) 1993-10-21
DE68909107T2 DE68909107T2 (de) 1994-02-17

Family

ID=10632375

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89301802T Expired - Fee Related DE68909107T2 (de) 1988-02-25 1989-02-23 4-Amino-3-acylchinolin-Derivate und ihre Verwendung als Inhibitoren der Magensekretion.

Country Status (16)

Country Link
US (1) US5143920A (de)
EP (1) EP0342775B1 (de)
JP (1) JPH02503316A (de)
KR (1) KR900700458A (de)
CN (1) CN1035663A (de)
AT (1) ATE94535T1 (de)
AU (1) AU3181789A (de)
DE (1) DE68909107T2 (de)
DK (1) DK528789A (de)
FI (1) FI895046A0 (de)
GB (1) GB8804443D0 (de)
HU (1) HU891462D0 (de)
PT (1) PT89788B (de)
WO (1) WO1989008105A1 (de)
ZA (1) ZA891389B (de)
ZW (1) ZW1889A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
AU634880B2 (en) * 1990-03-28 1993-03-04 Otsuka Pharmaceutical Co., Ltd. Quinoline derivative, antiulcer drug containing the same, and production of said derivative
FR2680510B1 (fr) * 1991-08-20 1995-06-23 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
FR2672596B1 (fr) * 1991-02-07 1995-07-13 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
GB9127252D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US5362743A (en) * 1993-03-09 1994-11-08 Pfizer Inc. Aminoquinoline derivatives
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US5650415A (en) * 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds
BR9914164A (pt) 1998-09-29 2001-06-26 American Cyanamid Co Composto, método para o tratamento, inibição do crescimento de, ou erradiacação de um neoplasma, e de doença de rim policìstico, em um mamìfero em necessidade do mesmo, composição farmacêutica, e, processo para preparar um composto
US7009053B2 (en) * 2002-04-30 2006-03-07 Yungjin Pharmaceuticals Co., Ltd. Quinoline derivatives as caspase-3 inhibitor, preparation for producing the same and pharmaceutical composition comprising the same
FR2873695A1 (fr) * 2004-07-30 2006-02-03 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un antibiotique ou un inhibiteur de resistance), leur synthese et leurs utilisations en tant qu'agent antibacterien
EP3700527A4 (de) * 2017-10-25 2021-03-10 Children's Medical Center Corporation Papd5-inhibitoren und verfahren zur verwendung davon

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2652398A (en) * 1949-11-17 1953-09-15 Endo Products Inc N-substituted-2-amino (methyl) quinolines
US3391146A (en) * 1964-11-10 1968-07-02 Bristol Myers Co Nu-substituted carbamates and thiocarbamates of 2-quinolinemethanols
US3470186A (en) * 1967-06-02 1969-09-30 American Cyanamid Co Substituted 4-anilino-3-quinolinecarboxylic acids and esters
CA942748A (en) * 1970-09-18 1974-02-26 Venkatachala L. Narayanan 1-aziridinylcarbonyl substituted-3-quinolinecarboxylic acid compounds
US4343804A (en) * 1979-03-26 1982-08-10 A. H. Robins Company, Inc. 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds

Also Published As

Publication number Publication date
DK528789D0 (da) 1989-10-24
ATE94535T1 (de) 1993-10-15
PT89788A (pt) 1989-10-04
FI895046A0 (fi) 1989-10-24
CN1035663A (zh) 1989-09-20
JPH02503316A (ja) 1990-10-11
WO1989008105A1 (en) 1989-09-08
EP0342775B1 (de) 1993-09-15
AU3181789A (en) 1989-09-22
DK528789A (da) 1989-10-24
ZW1889A1 (en) 1989-09-13
GB8804443D0 (en) 1988-03-23
HU891462D0 (en) 1990-01-28
PT89788B (pt) 1994-05-31
KR900700458A (ko) 1990-08-13
EP0342775A1 (de) 1989-11-23
ZA891389B (en) 1990-10-31
DE68909107T2 (de) 1994-02-17
US5143920A (en) 1992-09-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee