ZA883449B - Injectable opacifying composition containing liposomes of high encapsulation capacity of x-ray examinations - Google Patents
Injectable opacifying composition containing liposomes of high encapsulation capacity of x-ray examinationsInfo
- Publication number
- ZA883449B ZA883449B ZA883449A ZA883449A ZA883449B ZA 883449 B ZA883449 B ZA 883449B ZA 883449 A ZA883449 A ZA 883449A ZA 883449 A ZA883449 A ZA 883449A ZA 883449 B ZA883449 B ZA 883449B
- Authority
- ZA
- South Africa
- Prior art keywords
- injectable
- composition containing
- containing liposomes
- high encapsulation
- ray examinations
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000005538 encapsulation Methods 0.000 title 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
- A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1991/87A CH672733A5 (US20030157025A1-20030821-C00040.png) | 1987-05-22 | 1987-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA883449B true ZA883449B (en) | 1988-11-16 |
Family
ID=4223355
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA883449A ZA883449B (en) | 1987-05-22 | 1988-05-16 | Injectable opacifying composition containing liposomes of high encapsulation capacity of x-ray examinations |
Country Status (13)
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
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CH672733A5 (US20030157025A1-20030821-C00040.png) * | 1987-05-22 | 1989-12-29 | Bracco Ind Chimica Spa | |
MX9203504A (es) * | 1988-04-20 | 1992-07-01 | Liposome Co Inc | Complejo agente: lipido activo de alta proporcion. |
US5542935A (en) | 1989-12-22 | 1996-08-06 | Imarx Pharmaceutical Corp. | Therapeutic delivery systems related applications |
US6088613A (en) | 1989-12-22 | 2000-07-11 | Imarx Pharmaceutical Corp. | Method of magnetic resonance focused surgical and therapeutic ultrasound |
US5585112A (en) | 1989-12-22 | 1996-12-17 | Imarx Pharmaceutical Corp. | Method of preparing gas and gaseous precursor-filled microspheres |
US5469854A (en) * | 1989-12-22 | 1995-11-28 | Imarx Pharmaceutical Corp. | Methods of preparing gas-filled liposomes |
US5580575A (en) * | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
US5820848A (en) * | 1990-01-12 | 1998-10-13 | The Liposome Company, Inc. | Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent |
US6613306B1 (en) * | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US20010024638A1 (en) * | 1992-11-02 | 2001-09-27 | Michel Schneider | Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof |
US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
US6989141B2 (en) * | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
IN172208B (US20030157025A1-20030821-C00040.png) * | 1990-04-02 | 1993-05-01 | Sint Sa | |
US7083778B2 (en) * | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US20040208826A1 (en) * | 1990-04-02 | 2004-10-21 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
US20030194376A1 (en) * | 1990-05-18 | 2003-10-16 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
IS1685B (is) * | 1990-12-11 | 1998-02-24 | Bracco International B.V. | Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum |
US5447635A (en) * | 1991-02-26 | 1995-09-05 | Bracco International B.V. | Process of concentration and purification of organic compounds |
US5205290A (en) | 1991-04-05 | 1993-04-27 | Unger Evan C | Low density microspheres and their use as contrast agents for computed tomography |
SE470086B (sv) * | 1991-04-23 | 1993-11-08 | Kabi Pharmacia Ab | Organspecifik emulsion |
SE9101709L (sv) * | 1991-06-03 | 1992-12-04 | Karlshamns Lipidteknik Ab | Lipidderivat som diagnostikum eller kontrastmedel |
IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
AU5174193A (en) * | 1992-10-16 | 1994-05-09 | Georg Rossling | Process and device for producing liquid, dispersed systems |
DK0699068T3 (da) * | 1993-05-21 | 2002-03-11 | Liposome Co Inc | Reduktion af liposominducerede fysiologiske bivirkninger |
US6217849B1 (en) | 1993-09-29 | 2001-04-17 | Bracco Research S.A. | Liposome suspensions as blood pool imaging contrast agents |
HU225495B1 (en) * | 1993-12-15 | 2007-01-29 | Bracco Research Sa | Gas mixtures useful as ultrasound contrast media |
DE69527194T2 (de) * | 1994-03-28 | 2003-02-06 | Daiichi Pharmaceutical Co., Ltd. | Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel |
US6743779B1 (en) | 1994-11-29 | 2004-06-01 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
CA2187427A1 (en) * | 1995-02-24 | 1996-08-29 | Herve Tournier | Liposome suspensions as blood pool imaging contrast agents |
DE19518221A1 (de) * | 1995-05-10 | 1996-11-14 | Schering Ag | Verwendung nichtsteroidaler Entzündungshemmer zur Verbesserung der physiologischen Verträglichkeit partikulärer pharmazeutischer Zubereitungen |
US6521211B1 (en) | 1995-06-07 | 2003-02-18 | Bristol-Myers Squibb Medical Imaging, Inc. | Methods of imaging and treatment with targeted compositions |
CA2252617A1 (en) | 1996-05-01 | 1997-11-06 | Imarx Pharmaceutical Corp. | Methods for delivering compounds into a cell |
US6414139B1 (en) | 1996-09-03 | 2002-07-02 | Imarx Therapeutics, Inc. | Silicon amphiphilic compounds and the use thereof |
US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
US6537246B1 (en) | 1997-06-18 | 2003-03-25 | Imarx Therapeutics, Inc. | Oxygen delivery agents and uses for the same |
US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
US6548047B1 (en) | 1997-09-15 | 2003-04-15 | Bristol-Myers Squibb Medical Imaging, Inc. | Thermal preactivation of gaseous precursor filled compositions |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
JP4109780B2 (ja) | 1998-03-06 | 2008-07-02 | 株式会社東海理化電機製作所 | ギヤ機構及びウエビング巻取装置 |
AU757686B2 (en) * | 1998-03-31 | 2003-03-06 | New York University | Liposomal bupivacaine compositions and methods of preparation |
US6706280B2 (en) * | 1998-08-19 | 2004-03-16 | Bracco Research S.A. | Carboxylated phosphatidic acid esters |
JP3980777B2 (ja) | 1998-11-02 | 2007-09-26 | 株式会社東海理化電機製作所 | ウエビング巻取装置 |
US6426145B1 (en) | 1999-05-20 | 2002-07-30 | Scimed Life Systems, Inc. | Radiopaque compositions for visualization of medical devices |
US7297344B1 (en) | 1999-05-27 | 2007-11-20 | Euro-Celtique, S.A. | Preparations for the promotion of wound healing in the upper respiratory tract and/or ear |
US7300667B1 (en) | 1999-05-27 | 2007-11-27 | Euro-Celtique, S.A. | Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract |
RU2264827C2 (ru) | 1999-05-27 | 2005-11-27 | Еуро-Селтик С.А. | Препараты для введения противовоспалительных агентов |
EP2286843A3 (en) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Compounds for targeting endothelial cells |
JP2005170928A (ja) * | 2003-10-21 | 2005-06-30 | Konica Minolta Medical & Graphic Inc | リポソーム含有x線造影剤およびその製造方法 |
JP2005170923A (ja) * | 2003-10-21 | 2005-06-30 | Konica Minolta Medical & Graphic Inc | リポソーム含有x線造影剤およびその製造方法 |
JP4654590B2 (ja) * | 2004-03-31 | 2011-03-23 | コニカミノルタエムジー株式会社 | X線ct用造影組成物およびその製造方法 |
US8357351B2 (en) | 2004-04-21 | 2013-01-22 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
US7713517B2 (en) * | 2004-04-21 | 2010-05-11 | Marval Biosciences, Inc. | Compositions and methods for enhancing contrast in imaging |
JPWO2006009022A1 (ja) * | 2004-07-21 | 2008-05-01 | コニカミノルタエムジー株式会社 | リポソーム含有x線造影剤およびその製造方法 |
EP1776948B1 (en) * | 2004-08-11 | 2015-12-09 | Konica Minolta Medical & Graphic, Inc. | Method of producing liposome-containing preparation |
US20060110439A1 (en) * | 2004-10-22 | 2006-05-25 | Dynamis Therapeutics, Inc. | Dermal delivery of n-methyl-glucamine and n-methyl-glucamine compounds |
WO2007129311A2 (en) * | 2006-05-04 | 2007-11-15 | Pan Sci Tech S.A. | Nano-particles with contrast agents for diagnostic delivery system for x-ray and ct |
CA2708028A1 (en) | 2007-12-05 | 2009-06-11 | Marval Biosciences, Inc. | Nano-scale contrast agents and methods of use |
WO2009152445A1 (en) * | 2008-06-13 | 2009-12-17 | Marval Biosciences, Inc. | Imaging of atherosclerotic plaques using liposomal imaging agents |
CA2755998A1 (en) * | 2009-03-19 | 2010-09-23 | Marval Biosciences, Inc. | Compositions and methods for enhancing contrast in imaging |
US10894098B2 (en) | 2012-04-09 | 2021-01-19 | Signablok, Inc. | Methods and compositions for targeted imaging |
IT1404011B1 (it) | 2010-12-03 | 2013-11-08 | Uni Degli Studi Magna Graecia Di Catanzaro | Nanovettore coniugato con tsh per il trattamento del cancro della tiroide |
FR3017295B1 (fr) * | 2014-02-07 | 2018-01-12 | Guerbet | Composition destinee a vectoriser un agent anticancereux |
CN107206111B (zh) | 2014-12-31 | 2021-04-27 | 蓝瑟斯医学影像公司 | 脂质封装的气体微球组合物及相关方法 |
FR3039767B1 (fr) | 2015-08-04 | 2017-09-08 | Guerbet Sa | Composition destinee a vectoriser un agent anticancereux |
AU2017260532B2 (en) | 2016-05-04 | 2024-08-22 | Lantheus Medical Imaging, Inc. | Methods and devices for preparation of ultrasound contrast agents |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3957971A (en) * | 1974-07-29 | 1976-05-18 | Lever Brothers Company | Moisturizing units and moisturizing compositions containing the same |
US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4529561A (en) * | 1978-03-24 | 1985-07-16 | The Regents Of The University Of California | Method for producing liposomes in selected size range |
US4192859A (en) * | 1978-09-29 | 1980-03-11 | E. R. Squibb & Sons, Inc. | Contrast media containing liposomes as carriers |
CH641682A5 (en) * | 1978-10-05 | 1984-03-15 | Daeniker Felix | X-ray contrast medium |
US4241046A (en) * | 1978-11-30 | 1980-12-23 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4519024A (en) * | 1983-09-02 | 1985-05-21 | At&T Bell Laboratories | Two-terminal transistor rectifier circuit arrangement |
US4599227A (en) * | 1983-11-07 | 1986-07-08 | Wisconsin Alumni Research Foundation | Injectable pharmaceutical preparation for the induction of multiple follicular growth |
US4744989A (en) * | 1984-02-08 | 1988-05-17 | E. R. Squibb & Sons, Inc. | Method of preparing liposomes and products produced thereby |
US4567034A (en) * | 1984-09-07 | 1986-01-28 | E. R. Squibb & Sons, Inc. | Esters of diatrizoic acid as X-ray contrast agents |
CH672733A5 (US20030157025A1-20030821-C00040.png) * | 1987-05-22 | 1989-12-29 | Bracco Ind Chimica Spa |
-
1987
- 1987-05-22 CH CH1991/87A patent/CH672733A5/fr not_active IP Right Cessation
-
1988
- 1988-05-16 EP EP88904952A patent/EP0314764B2/en not_active Expired - Lifetime
- 1988-05-16 DE DE3874485T patent/DE3874485T3/de not_active Expired - Fee Related
- 1988-05-16 WO PCT/EP1988/000447 patent/WO1988009165A1/en active IP Right Grant
- 1988-05-16 US US07/302,690 patent/US5312615A/en not_active Expired - Fee Related
- 1988-05-16 JP JP63504697A patent/JP2619037B2/ja not_active Expired - Fee Related
- 1988-05-16 ZA ZA883449A patent/ZA883449B/xx unknown
- 1988-05-16 AT AT88904952T patent/ATE80294T1/de not_active IP Right Cessation
- 1988-05-16 AU AU18054/88A patent/AU612371B2/en not_active Ceased
- 1988-05-17 IL IL86409A patent/IL86409A/xx not_active IP Right Cessation
- 1988-05-20 ES ES8801604A patent/ES2009917A6/es not_active Expired
- 1988-05-20 CA CA000567314A patent/CA1303978C/en not_active Expired - Fee Related
-
1992
- 1992-06-24 MX MX9203271A patent/MX9203271A/es unknown
-
1993
- 1993-09-29 US US08/128,206 patent/US5445810A/en not_active Expired - Fee Related
-
1995
- 1995-05-12 US US08/440,134 patent/US5626832A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE80294T1 (de) | 1992-09-15 |
AU1805488A (en) | 1988-12-21 |
DE3874485D1 (de) | 1992-10-15 |
US5445810A (en) | 1995-08-29 |
WO1988009165A1 (en) | 1988-12-01 |
DE3874485T3 (de) | 2000-09-14 |
IL86409A0 (en) | 1988-11-15 |
ES2009917A6 (es) | 1989-10-16 |
JPH02500192A (ja) | 1990-01-25 |
EP0314764A1 (en) | 1989-05-10 |
DE3874485T2 (de) | 1993-03-11 |
JP2619037B2 (ja) | 1997-06-11 |
US5312615A (en) | 1994-05-17 |
US5626832A (en) | 1997-05-06 |
IL86409A (en) | 1991-12-12 |
EP0314764B2 (en) | 2000-02-02 |
AU612371B2 (en) | 1991-07-11 |
EP0314764B1 (en) | 1992-09-09 |
MX9203271A (es) | 1992-07-01 |
CH672733A5 (US20030157025A1-20030821-C00040.png) | 1989-12-29 |
CA1303978C (en) | 1992-06-23 |
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