ZA883449B - Injectable opacifying composition containing liposomes of high encapsulation capacity of x-ray examinations - Google Patents

Injectable opacifying composition containing liposomes of high encapsulation capacity of x-ray examinations

Info

Publication number
ZA883449B
ZA883449B ZA883449A ZA883449A ZA883449B ZA 883449 B ZA883449 B ZA 883449B ZA 883449 A ZA883449 A ZA 883449A ZA 883449 A ZA883449 A ZA 883449A ZA 883449 B ZA883449 B ZA 883449B
Authority
ZA
South Africa
Prior art keywords
injectable
composition containing
containing liposomes
high encapsulation
ray examinations
Prior art date
Application number
ZA883449A
Other languages
English (en)
Inventor
Schneider Michel
Tournier Herve
Lamy Bernard
Original Assignee
Bracco Industria Chimica S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4223355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA883449(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bracco Industria Chimica S.P.A. filed Critical Bracco Industria Chimica S.P.A.
Publication of ZA883449B publication Critical patent/ZA883449B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA883449A 1987-05-22 1988-05-16 Injectable opacifying composition containing liposomes of high encapsulation capacity of x-ray examinations ZA883449B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1991/87A CH672733A5 (US20030157025A1-20030821-C00031.png) 1987-05-22 1987-05-22

Publications (1)

Publication Number Publication Date
ZA883449B true ZA883449B (en) 1988-11-16

Family

ID=4223355

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA883449A ZA883449B (en) 1987-05-22 1988-05-16 Injectable opacifying composition containing liposomes of high encapsulation capacity of x-ray examinations

Country Status (13)

Country Link
US (3) US5312615A (US20030157025A1-20030821-C00031.png)
EP (1) EP0314764B2 (US20030157025A1-20030821-C00031.png)
JP (1) JP2619037B2 (US20030157025A1-20030821-C00031.png)
AT (1) ATE80294T1 (US20030157025A1-20030821-C00031.png)
AU (1) AU612371B2 (US20030157025A1-20030821-C00031.png)
CA (1) CA1303978C (US20030157025A1-20030821-C00031.png)
CH (1) CH672733A5 (US20030157025A1-20030821-C00031.png)
DE (1) DE3874485T3 (US20030157025A1-20030821-C00031.png)
ES (1) ES2009917A6 (US20030157025A1-20030821-C00031.png)
IL (1) IL86409A (US20030157025A1-20030821-C00031.png)
MX (1) MX9203271A (US20030157025A1-20030821-C00031.png)
WO (1) WO1988009165A1 (US20030157025A1-20030821-C00031.png)
ZA (1) ZA883449B (US20030157025A1-20030821-C00031.png)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672733A5 (US20030157025A1-20030821-C00031.png) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
MX9203504A (es) * 1988-04-20 1992-07-01 Liposome Co Inc Complejo agente: lipido activo de alta proporcion.
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5820848A (en) * 1990-01-12 1998-10-13 The Liposome Company, Inc. Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent
US6613306B1 (en) * 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
IN172208B (US20030157025A1-20030821-C00031.png) * 1990-04-02 1993-05-01 Sint Sa
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
IS1685B (is) * 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
US5447635A (en) * 1991-02-26 1995-09-05 Bracco International B.V. Process of concentration and purification of organic compounds
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
SE470086B (sv) * 1991-04-23 1993-11-08 Kabi Pharmacia Ab Organspecifik emulsion
SE9101709L (sv) * 1991-06-03 1992-12-04 Karlshamns Lipidteknik Ab Lipidderivat som diagnostikum eller kontrastmedel
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
AU5174193A (en) * 1992-10-16 1994-05-09 Georg Rossling Process and device for producing liquid, dispersed systems
DK0699068T3 (da) * 1993-05-21 2002-03-11 Liposome Co Inc Reduktion af liposominducerede fysiologiske bivirkninger
US6217849B1 (en) 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
HU225495B1 (en) * 1993-12-15 2007-01-29 Bracco Research Sa Gas mixtures useful as ultrasound contrast media
DE69527194T2 (de) * 1994-03-28 2003-02-06 Daiichi Pharmaceutical Co., Ltd. Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
CA2187427A1 (en) * 1995-02-24 1996-08-29 Herve Tournier Liposome suspensions as blood pool imaging contrast agents
DE19518221A1 (de) * 1995-05-10 1996-11-14 Schering Ag Verwendung nichtsteroidaler Entzündungshemmer zur Verbesserung der physiologischen Verträglichkeit partikulärer pharmazeutischer Zubereitungen
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
CA2252617A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
JP4109780B2 (ja) 1998-03-06 2008-07-02 株式会社東海理化電機製作所 ギヤ機構及びウエビング巻取装置
AU757686B2 (en) * 1998-03-31 2003-03-06 New York University Liposomal bupivacaine compositions and methods of preparation
US6706280B2 (en) * 1998-08-19 2004-03-16 Bracco Research S.A. Carboxylated phosphatidic acid esters
JP3980777B2 (ja) 1998-11-02 2007-09-26 株式会社東海理化電機製作所 ウエビング巻取装置
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
US7297344B1 (en) 1999-05-27 2007-11-20 Euro-Celtique, S.A. Preparations for the promotion of wound healing in the upper respiratory tract and/or ear
US7300667B1 (en) 1999-05-27 2007-11-27 Euro-Celtique, S.A. Preparations for the application of anti-inflammatory, especially antiseptic agents and/or agents promoting the healing of wounds, to the lower respiratory tract
RU2264827C2 (ru) 1999-05-27 2005-11-27 Еуро-Селтик С.А. Препараты для введения противовоспалительных агентов
EP2286843A3 (en) 2000-06-02 2011-08-03 Bracco Suisse SA Compounds for targeting endothelial cells
JP2005170928A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP2005170923A (ja) * 2003-10-21 2005-06-30 Konica Minolta Medical & Graphic Inc リポソーム含有ｘ線造影剤およびその製造方法
JP4654590B2 (ja) * 2004-03-31 2011-03-23 コニカミノルタエムジー株式会社 Ｘ線ｃｔ用造影組成物およびその製造方法
US8357351B2 (en) 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
US7713517B2 (en) * 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
JPWO2006009022A1 (ja) * 2004-07-21 2008-05-01 コニカミノルタエムジー株式会社 リポソーム含有ｘ線造影剤およびその製造方法
EP1776948B1 (en) * 2004-08-11 2015-12-09 Konica Minolta Medical & Graphic, Inc. Method of producing liposome-containing preparation
US20060110439A1 (en) * 2004-10-22 2006-05-25 Dynamis Therapeutics, Inc. Dermal delivery of n-methyl-glucamine and n-methyl-glucamine compounds
WO2007129311A2 (en) * 2006-05-04 2007-11-15 Pan Sci Tech S.A. Nano-particles with contrast agents for diagnostic delivery system for x-ray and ct
CA2708028A1 (en) 2007-12-05 2009-06-11 Marval Biosciences, Inc. Nano-scale contrast agents and methods of use
WO2009152445A1 (en) * 2008-06-13 2009-12-17 Marval Biosciences, Inc. Imaging of atherosclerotic plaques using liposomal imaging agents
CA2755998A1 (en) * 2009-03-19 2010-09-23 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
US10894098B2 (en) 2012-04-09 2021-01-19 Signablok, Inc. Methods and compositions for targeted imaging
IT1404011B1 (it) 2010-12-03 2013-11-08 Uni Degli Studi Magna Graecia Di Catanzaro Nanovettore coniugato con tsh per il trattamento del cancro della tiroide
FR3017295B1 (fr) * 2014-02-07 2018-01-12 Guerbet Composition destinee a vectoriser un agent anticancereux
CN107206111B (zh) 2014-12-31 2021-04-27 蓝瑟斯医学影像公司 脂质封装的气体微球组合物及相关方法
FR3039767B1 (fr) 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
AU2017260532B2 (en) 2016-05-04 2024-08-22 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957971A (en) * 1974-07-29 1976-05-18 Lever Brothers Company Moisturizing units and moisturizing compositions containing the same
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
CH641682A5 (en) * 1978-10-05 1984-03-15 Daeniker Felix X-ray contrast medium
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4519024A (en) * 1983-09-02 1985-05-21 At&T Bell Laboratories Two-terminal transistor rectifier circuit arrangement
US4599227A (en) * 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US4567034A (en) * 1984-09-07 1986-01-28 E. R. Squibb & Sons, Inc. Esters of diatrizoic acid as X-ray contrast agents
CH672733A5 (US20030157025A1-20030821-C00031.png) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa

Also Published As

Publication number Publication date
ATE80294T1 (de) 1992-09-15
AU1805488A (en) 1988-12-21
DE3874485D1 (de) 1992-10-15
US5445810A (en) 1995-08-29
WO1988009165A1 (en) 1988-12-01
DE3874485T3 (de) 2000-09-14
IL86409A0 (en) 1988-11-15
ES2009917A6 (es) 1989-10-16
JPH02500192A (ja) 1990-01-25
EP0314764A1 (en) 1989-05-10
DE3874485T2 (de) 1993-03-11
JP2619037B2 (ja) 1997-06-11
US5312615A (en) 1994-05-17
US5626832A (en) 1997-05-06
IL86409A (en) 1991-12-12
EP0314764B2 (en) 2000-02-02
AU612371B2 (en) 1991-07-11
EP0314764B1 (en) 1992-09-09
MX9203271A (es) 1992-07-01
CH672733A5 (US20030157025A1-20030821-C00031.png) 1989-12-29
CA1303978C (en) 1992-06-23

Similar Documents

Publication Publication Date Title
ZA883449B (en) Injectable opacifying composition containing liposomes of high encapsulation capacity of x-ray examinations
MY109875A (en) Novel formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight surfactants.
YU135384A (en) Process for preparing barium sulphate with increased flowability and density suitable as shadowing component at roentgen contrasting agents
KR900013952A (ko) 경구투여용 이부프로펜 조성물
ES8505646A1 (es) Procedimiento para la preparacion de un derivado de insulina
FR2285857B1 (US20030157025A1-20030821-C00031.png)
HK59984A (en) A process for the preparation of a sterile injectable physiologically acceptable solution of an x-ray contrast agent and solutions of the x-ray contrast agent and a buffer
Chan et al. Effect of fluoride on bone formation and strength in Japanese quail
Chidekel et al. Diagnosis of fluid in the maxillary sinus
EP0221728A3 (en) Monosaccharide containing wound healing preparation
JPS5750928A (en) Diagnostic agent for scanning bone
AU1879597A (en) Tetraether lipids and liposomes containing said lipids, and use of the same
McCabe et al. A radio-opaque denture material
DK484585A (da) Micellulaere partikelkompositioner, hvori er indkapslet billedtagende og kemoterapeutiske midler for tumorer, og kompositionernes anvendelse
HUT37767A (en) Process for preparing isoxazole derivatives further pharmaceutical compositions containing such compounds as active substances
Scheinin Flow characteristics of the pulpal vessels
HENTZER et al. The ultrastructure of Leishmania tropica in skin lesions
SU1169660A1 (ru) Рентгеноконтрастное средство
JPS6446475A (en) Guide wire for medical purpose
SU797687A1 (ru) Средство дл рентгенологическихи МАКРОАНгиОгРАфичЕСКиХ иССлЕдО-ВАНий
CA2142996A1 (en) Breast implant with radiolucent shell
US3855405A (en) Radiographic contrast composition containing 2{40 ,6{40 -diiodo-dl-thyronine and methods of use thereof
SE8106498L (sv) Kvaternera salter av n,n3-di(beta-brompropionyl)-n1,n2-dispirotripiperazinium, forfarande for framstellning av desamma och lekemedelspreparat innehallande desamma
JPS57157447A (en) Rotary anode for x-ray tube
USD239942S (en)