ZA879229B - Pyridazodiazepine derivatives - Google Patents

Pyridazodiazepine derivatives

Info

Publication number
ZA879229B
ZA879229B ZA879229A ZA879229A ZA879229B ZA 879229 B ZA879229 B ZA 879229B ZA 879229 A ZA879229 A ZA 879229A ZA 879229 A ZA879229 A ZA 879229A ZA 879229 B ZA879229 B ZA 879229B
Authority
ZA
South Africa
Prior art keywords
pyridazodiazepine
derivatives
pyridazodiazepine derivatives
Prior art date
Application number
ZA879229A
Other languages
English (en)
Inventor
Lawton Geoffrey
Redshaw Sally
Original Assignee
F. Hoffmann-La Roche & Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche & Co. Aktiengesellschaft filed Critical F. Hoffmann-La Roche & Co. Aktiengesellschaft
Publication of ZA879229B publication Critical patent/ZA879229B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA879229A 1986-12-15 1987-12-08 Pyridazodiazepine derivatives ZA879229B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868629875A GB8629875D0 (en) 1986-12-15 1986-12-15 Pyridazodiazepine derivatives

Publications (1)

Publication Number Publication Date
ZA879229B true ZA879229B (en) 1988-06-15

Family

ID=10609005

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA879229A ZA879229B (en) 1986-12-15 1987-12-08 Pyridazodiazepine derivatives

Country Status (17)

Country Link
US (2) US4757069A (fr)
EP (1) EP0271795A3 (fr)
JP (1) JPS63162693A (fr)
KR (1) KR880007538A (fr)
AU (1) AU602546B2 (fr)
CA (1) CA1291478C (fr)
DK (1) DK628087A (fr)
FI (1) FI85482C (fr)
GB (1) GB8629875D0 (fr)
HU (1) HU198492B (fr)
IL (1) IL84765A (fr)
MC (1) MC1879A1 (fr)
NO (1) NO166083C (fr)
NZ (1) NZ222825A (fr)
PH (1) PH23813A (fr)
PT (1) PT86365B (fr)
ZA (1) ZA879229B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69220744T2 (de) * 1991-09-27 1997-11-13 Merrell Pharma Inc 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
EP0625987B1 (fr) * 1992-02-14 1998-04-01 Merrell Pharmaceuticals Inc. Derives d'aminocetylmercaptoacetylamide utilises comme inhibiteurs de l'encephalinase et de l'enzyme de conversion d'angiotensine
KR100281450B1 (ko) * 1992-05-15 2001-02-01 슈테펜 엘. 네스비트 엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 신규 메르캅토아세틸아미도 피리다조[1,2]피리다진, 피라졸로[1,2]피리다진, 피리다조[1,2-a][1,2]디아제핀 및 피라졸로[1,2-a][1,2]디아제핀 유도체
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
DK0669936T3 (da) * 1992-10-30 2001-02-05 Merrell Pharma Inc Mercaptoacetylamidsubstitueret bicyklisk lactam til anvendelse som enkephalinase- og ACE-inhibitorer
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
JP3561753B2 (ja) * 1994-02-14 2004-09-02 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規な２−置換インダン−２−メルカプトアセチルアミドジスルフィド誘導体類
HUT74385A (en) * 1994-02-14 1996-12-30 Merrell Pharma Inc Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
DE69524064T2 (de) * 1994-02-14 2002-07-11 Merrell Pharma Inc Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
WO1995021839A1 (fr) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Nouveaux derives bisulfure de mercaptoacetylamides utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine (ace)
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
DK0751783T3 (da) * 1994-03-24 2000-06-26 Merrell Pharma Inc Hypokolesterolæmisk, antiatherosklerotisk og hypotriglyceridæmisk anvendelse af aminoacetylmercaptoderivater
NZ282565A (en) * 1994-03-24 1999-11-29 Merrell Pharma Inc Condensed mercaptoacetylamidedisulphidebenzazepines used in treating elevated cholesterol levels, atherosclerosis, and hypotriglyceridemia
AU2000265534A1 (en) * 2000-02-17 2001-08-27 China Petroleum And Chemical Corporation Multiblock copolymer the preparing method thereof
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
IE20070935A1 (en) * 2007-12-21 2009-06-24 Trinity College Dublin Guanidine based compounds and their use in the treatment of mental and neurological disorders.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092438A (en) * 1977-04-29 1978-05-30 Carnation Company Non-dairy coffee whitener containing acetate salt
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
GB8320764D0 (en) * 1983-08-02 1983-09-01 Rhodes Joseph Ltd Bending machines
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
EP0187037A3 (fr) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Dérivés de pipéridine, leur production et emploi

Also Published As

Publication number Publication date
FI875483A (fi) 1988-06-16
PT86365B (pt) 1990-11-20
NO166083C (no) 1991-05-29
MC1879A1 (fr) 1989-01-24
DK628087D0 (da) 1987-11-30
HU198492B (en) 1989-10-30
NZ222825A (en) 1990-11-27
FI85482B (fi) 1992-01-15
DK628087A (da) 1988-06-16
GB8629875D0 (en) 1987-01-28
IL84765A0 (en) 1988-05-31
NO875200L (no) 1988-06-16
HUT47279A (en) 1989-02-28
PH23813A (en) 1989-11-23
PT86365A (en) 1988-01-01
AU8225487A (en) 1988-06-16
AU602546B2 (en) 1990-10-18
EP0271795A2 (fr) 1988-06-22
NO875200D0 (no) 1987-12-14
KR880007538A (ko) 1988-08-27
JPS63162693A (ja) 1988-07-06
US4757069A (en) 1988-07-12
NO166083B (no) 1991-02-18
CA1291478C (fr) 1991-10-29
EP0271795A3 (fr) 1989-08-09
US4782149A (en) 1988-11-01
FI85482C (fi) 1992-04-27
FI875483A0 (fi) 1987-12-14
IL84765A (en) 1991-06-30

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