ZA879229B - Pyridazodiazepine derivatives - Google Patents

Pyridazodiazepine derivatives

Info

Publication number
ZA879229B
ZA879229B ZA879229A ZA879229A ZA879229B ZA 879229 B ZA879229 B ZA 879229B ZA 879229 A ZA879229 A ZA 879229A ZA 879229 A ZA879229 A ZA 879229A ZA 879229 B ZA879229 B ZA 879229B
Authority
ZA
South Africa
Prior art keywords
pyridazodiazepine
derivatives
pyridazodiazepine derivatives
Prior art date
Application number
ZA879229A
Other languages
English (en)
Inventor
Lawton Geoffrey
Redshaw Sally
Original Assignee
F. Hoffmann-La Roche & Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche & Co. Aktiengesellschaft filed Critical F. Hoffmann-La Roche & Co. Aktiengesellschaft
Publication of ZA879229B publication Critical patent/ZA879229B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA879229A 1986-12-15 1987-12-08 Pyridazodiazepine derivatives ZA879229B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868629875A GB8629875D0 (en) 1986-12-15 1986-12-15 Pyridazodiazepine derivatives

Publications (1)

Publication Number Publication Date
ZA879229B true ZA879229B (en) 1988-06-15

Family

ID=10609005

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA879229A ZA879229B (en) 1986-12-15 1987-12-08 Pyridazodiazepine derivatives

Country Status (17)

Country Link
US (2) US4757069A (fr)
EP (1) EP0271795A3 (fr)
JP (1) JPS63162693A (fr)
KR (1) KR880007538A (fr)
AU (1) AU602546B2 (fr)
CA (1) CA1291478C (fr)
DK (1) DK628087A (fr)
FI (1) FI85482C (fr)
GB (1) GB8629875D0 (fr)
HU (1) HU198492B (fr)
IL (1) IL84765A (fr)
MC (1) MC1879A1 (fr)
NO (1) NO166083C (fr)
NZ (1) NZ222825A (fr)
PH (1) PH23813A (fr)
PT (1) PT86365B (fr)
ZA (1) ZA879229B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
DE69220744T2 (de) * 1991-09-27 1997-11-13 Merrell Pharma Inc 2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
DK0625987T3 (da) * 1992-02-14 1999-01-11 Merrell Pharma Inc Aminoacetylmercaptoacetylamid-derivater, der kan anvendes som inhibitorer af enkephalinase og ACE
HU223663B1 (hu) * 1992-05-15 2004-11-29 Merrel Dow Pharmaceuticals Inc. Enkefalináz és ACE gátló hatású 9-[(2-acetil-tio-3-fenil)-propanoil-amino]-piridazo[1,2-a][1,2]diazepin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
EP0669936B1 (fr) * 1992-10-30 2000-11-22 Merrell Pharmaceuticals Inc. Derives de lactame bicyclique de mercaptoacetylamide utiles, comme inhibiteurs de l'encephalinase et de l'eca
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
WO1995021854A1 (fr) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Nouveaux derives bisulfure de mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepine-3-one utiles en tant qu'inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine
HUT76479A (en) * 1994-02-14 1997-09-29 Merrell Pharma Inc Novel fused benzazepinone derivatives, process for preparation thereof and pharmaceutical composition containing them
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
KR100357354B1 (ko) * 1994-02-14 2003-01-30 메렐 파마슈티칼스 인크. 엔케팔리나제및안지오텐신전환효소(ace)의억제제로서유용한신규의머캅토아세틸아미드디설파이드유도체
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
ATE189392T1 (de) * 1994-03-24 2000-02-15 Merrell Pharma Inc Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
JPH10503468A (ja) * 1994-03-24 1998-03-31 メリル・フアーマシユウテイカルズ・インコーポレイテツド 低コレステロール血性、抗アテローム性動脈硬化性および低トリグリセライド血性のメルカプトアセチルアミドジスルフィド誘導体
EP1266916B1 (fr) * 2000-02-17 2005-12-14 China Petroleum & Chemical Corporation Copolymere multisequence et son procede de preparation
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
IE20070935A1 (en) * 2007-12-21 2009-06-24 Trinity College Dublin Guanidine based compounds and their use in the treatment of mental and neurological disorders.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092438A (en) * 1977-04-29 1978-05-30 Carnation Company Non-dairy coffee whitener containing acetate salt
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
GB8320764D0 (en) * 1983-08-02 1983-09-01 Rhodes Joseph Ltd Bending machines
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
EP0187037A3 (fr) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Dérivés de pipéridine, leur production et emploi

Also Published As

Publication number Publication date
FI85482C (fi) 1992-04-27
AU602546B2 (en) 1990-10-18
IL84765A0 (en) 1988-05-31
NO166083B (no) 1991-02-18
NO166083C (no) 1991-05-29
NO875200D0 (no) 1987-12-14
JPS63162693A (ja) 1988-07-06
NO875200L (no) 1988-06-16
US4782149A (en) 1988-11-01
NZ222825A (en) 1990-11-27
GB8629875D0 (en) 1987-01-28
HU198492B (en) 1989-10-30
AU8225487A (en) 1988-06-16
EP0271795A2 (fr) 1988-06-22
FI875483A0 (fi) 1987-12-14
DK628087A (da) 1988-06-16
MC1879A1 (fr) 1989-01-24
KR880007538A (ko) 1988-08-27
HUT47279A (en) 1989-02-28
FI85482B (fi) 1992-01-15
DK628087D0 (da) 1987-11-30
FI875483A (fi) 1988-06-16
US4757069A (en) 1988-07-12
PT86365B (pt) 1990-11-20
EP0271795A3 (fr) 1989-08-09
PH23813A (en) 1989-11-23
IL84765A (en) 1991-06-30
PT86365A (en) 1988-01-01
CA1291478C (fr) 1991-10-29

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