ZA879229B - Pyridazodiazepine derivatives - Google Patents

Pyridazodiazepine derivatives

Info

Publication number
ZA879229B
ZA879229B ZA879229A ZA879229A ZA879229B ZA 879229 B ZA879229 B ZA 879229B ZA 879229 A ZA879229 A ZA 879229A ZA 879229 A ZA879229 A ZA 879229A ZA 879229 B ZA879229 B ZA 879229B
Authority
ZA
South Africa
Prior art keywords
pyridazodiazepine
derivatives
pyridazodiazepine derivatives
Prior art date
Application number
ZA879229A
Other languages
English (en)
Inventor
Lawton Geoffrey
Redshaw Sally
Original Assignee
F. Hoffmann-La Roche & Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche & Co. Aktiengesellschaft filed Critical F. Hoffmann-La Roche & Co. Aktiengesellschaft
Publication of ZA879229B publication Critical patent/ZA879229B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA879229A 1986-12-15 1987-12-08 Pyridazodiazepine derivatives ZA879229B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868629875A GB8629875D0 (en) 1986-12-15 1986-12-15 Pyridazodiazepine derivatives

Publications (1)

Publication Number Publication Date
ZA879229B true ZA879229B (en) 1988-06-15

Family

ID=10609005

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA879229A ZA879229B (en) 1986-12-15 1987-12-08 Pyridazodiazepine derivatives

Country Status (17)

Country Link
US (2) US4757069A (fi)
EP (1) EP0271795A3 (fi)
JP (1) JPS63162693A (fi)
KR (1) KR880007538A (fi)
AU (1) AU602546B2 (fi)
CA (1) CA1291478C (fi)
DK (1) DK628087A (fi)
FI (1) FI85482C (fi)
GB (1) GB8629875D0 (fi)
HU (1) HU198492B (fi)
IL (1) IL84765A (fi)
MC (1) MC1879A1 (fi)
NO (1) NO166083C (fi)
NZ (1) NZ222825A (fi)
PH (1) PH23813A (fi)
PT (1) PT86365B (fi)
ZA (1) ZA879229B (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
EP0534363B1 (en) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
DE69317764T2 (de) * 1992-02-14 1998-07-30 Merrell Pharma Inc Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
JP3360079B2 (ja) * 1992-05-15 2002-12-24 メレルダウファーマスーティカルズ インコーポレイテッド エンケファリナーゼ及びＡＣＥの阻害剤として有用な新規なメルカプトアセチルアミドピリダゾ［１，２］ピリダジン、ピラゾロ［１，２］ピリダジン、ピリダゾ［１，２‐ａ］［１，２］ジアゼピン、及びピラゾロ［１，２‐ａ］［１，２］ジアゼピン誘導体類
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
ATE197714T1 (de) * 1992-10-30 2000-12-15 Merrell Pharma Inc Mercaptoacetylamid substituiertes bizyclisches laktam zur verwendung als enkephalinase und ace- hemmer
WO1995021857A1 (en) * 1994-02-14 1995-08-17 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
AU691243B2 (en) * 1994-02-14 1998-05-14 Aventisub Ii Inc. Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo(c)azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
JP3596778B2 (ja) * 1994-02-14 2004-12-02 メレル ファーマスーティカルズ インコーポレーテッド エンケファリナーゼ及びａｃｅの阻害剤として有用な、新規なメルカプトアセチルアミドジスルフィド誘導体類
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
ATE209205T1 (de) * 1994-02-14 2001-12-15 Merrell Pharma Inc Indan-2-mercaptoacetylamid disulfidderivate als enkephalinase inhibitoren
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
DE69514912T2 (de) * 1994-03-24 2000-10-05 Merrell Pharma Inc Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
WO1995025519A1 (en) * 1994-03-24 1995-09-28 Merrell Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
AU2000265534A1 (en) * 2000-02-17 2001-08-27 China Petroleum And Chemical Corporation Multiblock copolymer the preparing method thereof
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
IE20070935A1 (en) * 2007-12-21 2009-06-24 Trinity College Dublin Guanidine based compounds and their use in the treatment of mental and neurological disorders.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4092438A (en) * 1977-04-29 1978-05-30 Carnation Company Non-dairy coffee whitener containing acetate salt
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
GB8320764D0 (en) * 1983-08-02 1983-09-01 Rhodes Joseph Ltd Bending machines
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use

Also Published As

Publication number Publication date
NO166083C (no) 1991-05-29
FI875483A0 (fi) 1987-12-14
NO166083B (no) 1991-02-18
US4782149A (en) 1988-11-01
HUT47279A (en) 1989-02-28
MC1879A1 (fr) 1989-01-24
PT86365A (en) 1988-01-01
NO875200L (no) 1988-06-16
FI875483A (fi) 1988-06-16
FI85482C (fi) 1992-04-27
IL84765A (en) 1991-06-30
EP0271795A2 (de) 1988-06-22
AU602546B2 (en) 1990-10-18
JPS63162693A (ja) 1988-07-06
NO875200D0 (no) 1987-12-14
IL84765A0 (en) 1988-05-31
EP0271795A3 (de) 1989-08-09
US4757069A (en) 1988-07-12
AU8225487A (en) 1988-06-16
DK628087D0 (da) 1987-11-30
FI85482B (fi) 1992-01-15
PH23813A (en) 1989-11-23
KR880007538A (ko) 1988-08-27
GB8629875D0 (en) 1987-01-28
NZ222825A (en) 1990-11-27
DK628087A (da) 1988-06-16
PT86365B (pt) 1990-11-20
CA1291478C (en) 1991-10-29
HU198492B (en) 1989-10-30

Similar Documents

Publication Publication Date Title
GB2190676B (en) Imidazoquinolinylether derivatives
EP0253500A3 (en) Acylanilide derivatives
GB8719310D0 (en) Piperidylaminotriazine derivatives
GB2198132B (en) 1-piperazinylpyrimidine derivatives
ZA879229B (en) Pyridazodiazepine derivatives
GB2185483B (en) Pyroglutamide derivatives
EP0247381A3 (en) 5-flurorouracil derivatives
GB2198729B (en) Azaspirodecane derivatives
EP0269839B1 (en) 5-acylamino-pyrazole derivatives
AR245109A1 (es) Un procedimiento para la preparacion de 5-fenil-5h-indeno/1,2-d/ pirimidina.
IL82726A0 (en) Aralkylimidazole derivatives
EP0246002A3 (en) Alkenamide derivatives
GB2186575B (en) Abietamide derivatives
GB2189487B (en) Ergolene derivatives
EP0267024A3 (en) Hydrofluorene derivatives
GR870728B (en) Tetrahydronaphalin derivatives
EP0244193A3 (en) Dihalogen-substituted thiocyanopyrimidine derivatives
GB8705006D0 (en) 5-acyloxy-13beta-alkyl-milbemycin derivatives
HRP920559B1 (en) Oxadiazolylalkylpurine derivatives
IE861252L (en) Quinolylglycinamide derivatives
IE860547L (en) Labdan derivatives
IE863276L (en) 10ß-ALKYNYLESTRENE DERIVATIVES
GB8628524D0 (en) Benzothiopyranone derivatives
GB8622071D0 (en) Hydroxtheteroaryl derivatives
IE860836L (en) Dichlorotrifluoroethoxy-and ethylthiobenzene derivatives