ZA878946B - Novel prostacyclines - Google Patents

Novel prostacyclines

Info

Publication number
ZA878946B
ZA878946B ZA878946A ZA878946A ZA878946B ZA 878946 B ZA878946 B ZA 878946B ZA 878946 A ZA878946 A ZA 878946A ZA 878946 A ZA878946 A ZA 878946A ZA 878946 B ZA878946 B ZA 878946B
Authority
ZA
South Africa
Prior art keywords
prostacyclines
novel
novel prostacyclines
Prior art date
Application number
ZA878946A
Other languages
English (en)
Inventor
William Holland George
Lee Ferdinand
Maag Hans
Rosen Perry
Original Assignee
F. Hoffmann-La Roche & Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche & Co. Aktiengesellschaft filed Critical F. Hoffmann-La Roche & Co. Aktiengesellschaft
Publication of ZA878946B publication Critical patent/ZA878946B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018Esters of cycloaliphatic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
ZA878946A 1986-12-01 1987-11-27 Novel prostacyclines ZA878946B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/936,569 US4808734A (en) 1986-12-01 1986-12-01 16-cycloalkyl-7-fluoro-prostacyclins

Publications (1)

Publication Number Publication Date
ZA878946B true ZA878946B (en) 1988-06-01

Family

ID=25468824

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA878946A ZA878946B (en) 1986-12-01 1987-11-27 Novel prostacyclines

Country Status (15)

Country Link
US (1) US4808734A (sv)
JP (1) JPS63145276A (sv)
AT (1) AT392071B (sv)
AU (1) AU604792B2 (sv)
BE (1) BE1001109A3 (sv)
CH (1) CH673650A5 (sv)
DE (1) DE3740596A1 (sv)
DK (1) DK627887A (sv)
FR (1) FR2607500A1 (sv)
GB (1) GB2198131B (sv)
IT (1) IT1223391B (sv)
NL (1) NL8702881A (sv)
NZ (1) NZ222724A (sv)
SE (1) SE8704771L (sv)
ZA (1) ZA878946B (sv)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW208001B (sv) * 1990-09-07 1993-06-21 Asahi Glass Co Ltd

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513913A (en) * 1975-06-20 1978-06-14 Ici Ltd Prostane derivatives
US4565827A (en) * 1980-10-27 1986-01-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
EP0054795B1 (en) * 1980-12-09 1987-07-15 Teijin Limited Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
CH651033A5 (de) * 1981-03-11 1985-08-30 Hoffmann La Roche Fluorprostacycline.
US4558142A (en) * 1981-03-11 1985-12-10 Hoffmann-La Roche Inc. 7-Fluoro-prostacyclin analogs
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
JPS59227888A (ja) * 1983-06-10 1984-12-21 Asahi Glass Co Ltd 7−フルオロプロスタグランジン類の製造方法
HU191264B (en) * 1984-01-13 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for production of derivatives of 7-oxo-prostacyclin with selective biological effect
JPS60243079A (ja) * 1984-05-18 1985-12-03 Asahi Glass Co Ltd 7―フルオロプロスタグランジンi↓2類を有効成分とする薬剤
US4616034A (en) * 1985-02-28 1986-10-07 G. D. Searle & Co. 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof
JPS61289034A (ja) * 1985-06-17 1986-12-19 Teijin Ltd イソカルバサイクリン類脂肪乳剤
FR2583828B1 (fr) * 1985-06-21 1987-08-14 Kley France Sa Appareil moteur fonctionnant par reprises successives
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds

Also Published As

Publication number Publication date
FR2607500A1 (fr) 1988-06-03
US4808734A (en) 1989-02-28
DE3740596A1 (de) 1988-06-16
AU604792B2 (en) 1991-01-03
CH673650A5 (sv) 1990-03-30
SE8704771D0 (sv) 1987-11-30
BE1001109A3 (fr) 1989-07-18
AU8190887A (en) 1988-06-02
ATA313787A (de) 1990-07-15
IT1223391B (it) 1990-09-19
GB2198131A (en) 1988-06-08
SE8704771L (sv) 1988-06-02
DK627887A (da) 1988-06-02
JPS63145276A (ja) 1988-06-17
AT392071B (de) 1991-01-25
IT8722815A0 (it) 1987-11-30
NL8702881A (nl) 1988-07-01
NZ222724A (en) 1990-11-27
DK627887D0 (da) 1987-11-30
GB2198131B (en) 1990-08-08
GB8727992D0 (en) 1988-01-06

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