ZA875489B - Diphosphonic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents
Diphosphonic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing themInfo
- Publication number
- ZA875489B ZA875489B ZA875489A ZA875489A ZA875489B ZA 875489 B ZA875489 B ZA 875489B ZA 875489 A ZA875489 A ZA 875489A ZA 875489 A ZA875489 A ZA 875489A ZA 875489 B ZA875489 B ZA 875489B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydrogen atom
- lower alkyl
- pharmaceutical compositions
- compositions containing
- het
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical class OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 201000008482 osteoarthritis Diseases 0.000 abstract 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 abstract 1
- 206010007027 Calculus urinary Diseases 0.000 abstract 1
- 206010027452 Metastases to bone Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000003913 calcium metabolism Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000011164 ossification Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 208000008281 urolithiasis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
- C07F9/65324—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C07F9/6541—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863626058 DE3626058A1 (de) | 1986-08-01 | 1986-08-01 | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA875489B true ZA875489B (en) | 1988-04-27 |
Family
ID=6306478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA875489A ZA875489B (en) | 1986-08-01 | 1987-07-27 | Diphosphonic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing them |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4777163A (fr) |
| EP (1) | EP0258618B1 (fr) |
| JP (1) | JPH0725780B2 (fr) |
| KR (1) | KR900004043B1 (fr) |
| AT (1) | ATE75748T1 (fr) |
| AU (1) | AU605778B2 (fr) |
| CA (1) | CA1338895C (fr) |
| CS (1) | CS266345B2 (fr) |
| DD (1) | DD264442A5 (fr) |
| DE (3) | DE3626058A1 (fr) |
| DK (1) | DK168820B1 (fr) |
| ES (1) | ES2032782T3 (fr) |
| FI (1) | FI87223C (fr) |
| GR (1) | GR3004499T3 (fr) |
| HK (1) | HK47096A (fr) |
| HU (1) | HU198078B (fr) |
| IE (1) | IE60233B1 (fr) |
| IL (1) | IL83332A (fr) |
| LU (1) | LU90836I2 (fr) |
| MX (1) | MX7510A (fr) |
| NL (1) | NL300059I2 (fr) |
| PT (1) | PT85457B (fr) |
| ZA (1) | ZA875489B (fr) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| EP0275821B1 (fr) * | 1986-11-21 | 1992-02-26 | Ciba-Geigy Ag | Acides alcanediphosphoniques substitués |
| DE3640938A1 (de) * | 1986-11-29 | 1988-06-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindung enthaltende arzneimittel |
| US4973576A (en) * | 1987-03-10 | 1990-11-27 | Yamanouchi Pharmaceutical Co., Ltd. | Bisphophonic acid derivatives and pharmaceutical compositions containing the same |
| EP0317505A1 (fr) * | 1987-11-13 | 1989-05-24 | Ciba-Geigy Ag | Acides azacycloalkylalcanediphosphoniques |
| US5190930A (en) * | 1987-12-11 | 1993-03-02 | Ciba-Geigy Corporation | Araliphatylaminoalkanediphosphonic acids |
| US5110807A (en) * | 1988-12-01 | 1992-05-05 | Ciba-Geigy Corporation | Araliphatylaminoalkanediphosphonic acids |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4990503A (en) * | 1988-08-12 | 1991-02-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic bisphosphonic acid derivatives |
| US4898606A (en) * | 1988-10-14 | 1990-02-06 | Fmc Corporation | Phosphorylaminophenyltriazolinone herbicides |
| US4932996A (en) * | 1988-10-18 | 1990-06-12 | Fmc Corporation | Phosphorylaminophenyltetrazolinone herbicides |
| US4954159A (en) * | 1988-10-18 | 1990-09-04 | Fmc Corporation | Phosphorylaminophenyltetrahydrophthalimide herbicides |
| US4902338A (en) * | 1988-11-04 | 1990-02-20 | Fmc Corporation | Phosphorylaminophenylhydantoin herbicides |
| US4983592A (en) * | 1988-12-19 | 1991-01-08 | American Cyanamid Co. | Bis-arylphosphate ester antagonists of platelet activating factor |
| US5147864A (en) * | 1988-12-19 | 1992-09-15 | American Cyanamid Company | Bis-arylphosphate ester antagonists of platelet activating factor |
| US5231091A (en) * | 1988-12-19 | 1993-07-27 | American Cyanamid Company | Bis-arylphosphate ester antagonists of platelet activating factor |
| DE3917153A1 (de) * | 1989-05-26 | 1990-11-29 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| MX21452A (es) * | 1989-07-07 | 1994-01-31 | Ciba Geigy Ag | Preparaciones farmaceuticas que se administran en forma topica. |
| US5139786A (en) * | 1989-07-07 | 1992-08-18 | Ciba-Geigy Corporation | Topical formulations |
| US5204334A (en) * | 1990-10-18 | 1993-04-20 | Ciba-Geigy Corporation | Benzoheterocyclylalkylaminoalkanediphosphonic acids, compositions thereof, and use thereof in the treatment of calcium metabolism disorders |
| US5202111A (en) * | 1991-05-09 | 1993-04-13 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Phosphorylated polyhydroxy compounds for tartar control |
| EP0521622B1 (fr) * | 1991-07-03 | 1997-08-13 | PHARMACIA & UPJOHN COMPANY | Esters de l'acide pyrazolopyrimidine et pyrimidinyl bisphosphonique comme anti-inflammatoires |
| EP0663919A1 (fr) * | 1992-10-09 | 1995-07-26 | PHARMACIA & UPJOHN COMPANY | Esters de biphosphonate de pyrimidine utilises comme anti-inflammatoires |
| US5591730A (en) * | 1993-10-12 | 1997-01-07 | The Regents Of The University Of California | Inhibition of urinary calculi growth |
| US5854227A (en) * | 1994-03-04 | 1998-12-29 | Hartmann; John F. | Therapeutic derivatives of diphosphonates |
| US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
| US6677320B2 (en) | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
| US6410520B2 (en) | 2000-02-01 | 2002-06-25 | The Procter & Gamble Company | Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate |
| US6562974B2 (en) | 2000-02-01 | 2003-05-13 | The Procter & Gamble Company | Process for making geminal bisphosphonates |
| CA2407747C (fr) | 2000-05-05 | 2008-03-11 | F. Hoffmann-La Roche Ag | Composition pharmaceutique de type gel pour administration sous-cutanee contenant des acides biphosphoniques ou leurs sels |
| WO2003055496A1 (fr) * | 2001-12-21 | 2003-07-10 | The Procter & Gamble Company | Methode de traitement d'affections osseuses |
| KR20120065435A (ko) | 2002-05-10 | 2012-06-20 | 에프. 호프만-라 로슈 아게 | 골다공증 치료 및 예방용 비스포스폰산 |
| BR0313081A (pt) * | 2002-07-30 | 2005-07-12 | Novartis Ag | Combinação de um inibidor de aromatase com um bisfosfanato |
| BR0309691A (pt) * | 2002-12-20 | 2005-08-02 | Hoffmann La Roche | Formulação de ibandronato em alta dose |
| US20040230076A1 (en) * | 2003-02-27 | 2004-11-18 | Revital Lifshitz-Liron | Process for purification of zoledronic acid |
| US20050054616A1 (en) * | 2003-07-03 | 2005-03-10 | Judith Aronhime | Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation |
| US20050049693A1 (en) * | 2003-08-25 | 2005-03-03 | Medtronic Vascular Inc. | Medical devices and compositions for delivering biophosphonates to anatomical sites at risk for vascular disease |
| US20050119230A1 (en) * | 2003-09-18 | 2005-06-02 | Alexandra Glausch | Pharmaceutical products comprising bisphosphonated |
| US7214671B2 (en) * | 2004-02-19 | 2007-05-08 | Wisconsin Alumni Research Foundation | Use of 2-methylene-19-nor-20(S)-1α,25-dihydroxyvitamin D3 for the prophylaxis of bone diseases |
| US8012949B2 (en) * | 2004-10-08 | 2011-09-06 | The Board Of Trustees Of The University Of Illinois | Bisphosphonate compounds and methods with enhanced potency for multiple targets including FPPS, GGPPS, and DPPS |
| US7358361B2 (en) * | 2004-10-08 | 2008-04-15 | The Board Of Trustees Of The University Of Illinois | Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases |
| AR054673A1 (es) | 2005-07-28 | 2007-07-11 | Gador Sa | Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende |
| CA2646334A1 (fr) * | 2006-03-17 | 2007-09-27 | The Board Of Trustees Of The University Of Illinois | Composes de biphosphonates et procedes |
| AU2007335156A1 (en) * | 2006-12-20 | 2008-06-26 | Mylan Pharmaceuticals Ulc | Pharmaceutical composition comprising a hot-melt granulated lubricant |
| CA2671727C (fr) | 2006-12-20 | 2016-02-16 | Genpharm Ulc | Composition contenant un acide bisphosphonique combine a de la vitamine d |
| US20090023683A1 (en) * | 2007-07-16 | 2009-01-22 | Chandrasekhar Kocherlakota | Complexes comprising zoledronic acid and cyclodextrins |
| WO2009105140A2 (fr) | 2007-12-11 | 2009-08-27 | Viamet Pharmaceuticals, Inc. | Inhibiteurs de métalloenzymes utilisant des fractions de liaison à un métal en combinaison avec des fractions de ciblage |
| EA201001578A1 (ru) * | 2008-04-04 | 2011-06-30 | Новартис Аг | Фармацевтическая композиция с бисфосфонатом |
| MX2011006605A (es) * | 2008-12-23 | 2011-06-30 | Novartis Ag | Compuestos de fenilalquilo-imidazol-bifosfonato. |
| FR2954320B1 (fr) | 2009-12-17 | 2012-06-15 | Cll Pharma | Composition pharmaceutique orale suprabiodisponible contenant un acide biphosphonique ou un de ses sels |
| US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
| US8748097B1 (en) | 2011-12-02 | 2014-06-10 | President And Fellows Of Harvard College | Identification of agents for treating calcium disorders and uses thereof |
| EP3105238A4 (fr) | 2014-02-13 | 2017-11-08 | Ligand Pharmaceuticals, Inc. | Composés de promédicaments et leurs utilisations |
| PL407922A1 (pl) | 2014-04-16 | 2015-10-26 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Nowe bisfosfoniany i ich zastosowanie |
| WO2016003812A1 (fr) | 2014-07-02 | 2016-01-07 | Ligand Pharmaceuticals, Inc. | Composés de promédicaments et leurs utilisations |
| WO2019076269A1 (fr) | 2017-10-16 | 2019-04-25 | 清华大学 | Inhibiteur de la voie de l'acide mévalonique et composition pharmaceutique correspondante |
| US11613644B2 (en) * | 2017-11-20 | 2023-03-28 | Basf Se | Aqueous acrylic polymer latexes and their use as binders |
| CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0084822B1 (fr) * | 1982-01-27 | 1986-01-08 | Schering Aktiengesellschaft | Dérivés d'acides diphosphoniques et préparations pharmaceutiques les contenant |
| DE3203307A1 (de) * | 1982-01-27 | 1983-07-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Phosphonate, und diese enthaltende pharmazeutische verbindungen |
| DE3203308A1 (de) * | 1982-01-27 | 1983-07-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| EP0275821B1 (fr) * | 1986-11-21 | 1992-02-26 | Ciba-Geigy Ag | Acides alcanediphosphoniques substitués |
-
1986
- 1986-08-01 DE DE19863626058 patent/DE3626058A1/de not_active Withdrawn
-
1987
- 1987-07-24 US US07/077,228 patent/US4777163A/en not_active Expired - Lifetime
- 1987-07-25 AT AT87110830T patent/ATE75748T1/de active
- 1987-07-25 DE DE2001199050 patent/DE10199050I1/de active Pending
- 1987-07-25 ES ES198787110830T patent/ES2032782T3/es not_active Expired - Lifetime
- 1987-07-25 EP EP87110830A patent/EP0258618B1/fr not_active Expired - Lifetime
- 1987-07-25 DE DE8787110830T patent/DE3778800D1/de not_active Expired - Lifetime
- 1987-07-26 IL IL83332A patent/IL83332A/xx not_active IP Right Cessation
- 1987-07-27 MX MX751087A patent/MX7510A/es unknown
- 1987-07-27 ZA ZA875489A patent/ZA875489B/xx unknown
- 1987-07-29 CA CA000543290A patent/CA1338895C/fr not_active Expired - Lifetime
- 1987-07-29 AU AU76256/87A patent/AU605778B2/en not_active Expired
- 1987-07-30 DK DK398187A patent/DK168820B1/da not_active IP Right Cessation
- 1987-07-30 JP JP62189069A patent/JPH0725780B2/ja not_active Expired - Lifetime
- 1987-07-30 CS CS875702A patent/CS266345B2/cs not_active IP Right Cessation
- 1987-07-30 PT PT85457A patent/PT85457B/pt unknown
- 1987-07-30 DD DD87305527A patent/DD264442A5/de not_active IP Right Cessation
- 1987-07-31 FI FI873339A patent/FI87223C/fi not_active IP Right Cessation
- 1987-07-31 IE IE208387A patent/IE60233B1/en not_active IP Right Cessation
- 1987-07-31 HU HU873542A patent/HU198078B/hu active Protection Beyond IP Right Term
- 1987-08-01 KR KR1019870008480A patent/KR900004043B1/ko not_active IP Right Cessation
-
1992
- 1992-05-07 GR GR900400209T patent/GR3004499T3/el unknown
-
1996
- 1996-03-14 HK HK47096A patent/HK47096A/xx not_active IP Right Cessation
-
2001
- 2001-09-18 NL NL300059C patent/NL300059I2/nl unknown
- 2001-09-19 LU LU90836C patent/LU90836I2/fr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA875489B (en) | Diphosphonic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing them | |
| AU598569B2 (en) | Diphosphonic acid derivatives and medicines containing them |