ZA873778B - 1,4-dihydropyridines,to their obtention processes and to their use as antithrombotic drugs - Google Patents

1,4-dihydropyridines,to their obtention processes and to their use as antithrombotic drugs

Info

Publication number
ZA873778B
ZA873778B ZA873778A ZA873778A ZA873778B ZA 873778 B ZA873778 B ZA 873778B ZA 873778 A ZA873778 A ZA 873778A ZA 873778 A ZA873778 A ZA 873778A ZA 873778 B ZA873778 B ZA 873778B
Authority
ZA
South Africa
Prior art keywords
dihydropyridines
obtention
processes
antithrombotic drugs
antithrombotic
Prior art date
Application number
ZA873778A
Other languages
English (en)
Inventor
Sunkel Carlos
Fau De Casa-Juana Miguel
Dorrego Fernando
Priego Jaime
Ortega Pilar
Cillero Javier
Original Assignee
Alter, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alter, S.A. filed Critical Alter, S.A.
Publication of ZA873778B publication Critical patent/ZA873778B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA873778A 1986-05-28 1987-05-26 1,4-dihydropyridines,to their obtention processes and to their use as antithrombotic drugs ZA873778B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863617976 DE3617976A1 (de) 1986-05-28 1986-05-28 1,4-dihydropyridin, verfahren zu dessen herstellung und dessen verwendung in antithrombotischen medikamenten

Publications (1)

Publication Number Publication Date
ZA873778B true ZA873778B (en) 1987-11-20

Family

ID=6301807

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA873778A ZA873778B (en) 1986-05-28 1987-05-26 1,4-dihydropyridines,to their obtention processes and to their use as antithrombotic drugs

Country Status (12)

Country Link
US (1) US4782069A (fr)
EP (1) EP0253092B1 (fr)
JP (1) JPS62289578A (fr)
AR (1) AR243185A1 (fr)
AT (1) AT395011B (fr)
CA (1) CA1311481C (fr)
DE (1) DE3617976A1 (fr)
ES (1) ES2004141A6 (fr)
GR (1) GR870824B (fr)
MX (1) MX163341A (fr)
PT (1) PT84959B (fr)
ZA (1) ZA873778B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4003541C1 (fr) * 1990-02-06 1991-08-08 Alter S.A., Madrid, Es
US5306818A (en) * 1990-11-01 1994-04-26 Sterling Winthrop Inc. Tetrahydro 2-saccharinylmerthyl aryl carboxylates
AU642537B2 (en) * 1990-11-01 1993-10-21 Sanofi 2-saccharinylmethyl aryl carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
AU668694B2 (en) * 1991-12-19 1996-05-16 Sanofi-Synthelabo Saccharin derivative proteolytic enzyme inhibitors
US5378720A (en) * 1991-12-19 1995-01-03 Sterling Winthrop Inc. Saccharin derivative proteolytic enzyme inhibitors
AU653279B2 (en) * 1991-12-30 1994-09-22 Sanofi Novel 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
TW226016B (fr) * 1991-12-30 1994-07-01 Sterling Winthrop Inc
WO1995014018A1 (fr) * 1993-11-19 1995-05-26 Laboratorios Alter, S.A. Nouveaux derives de 1,4-dihidropyridine, procede pour leur preparation et utilisation en tant qu'agents therapeutiques
EP0771560A1 (fr) * 1995-08-25 1997-05-07 Laboratorios Alter, S.A. Emploi du 2-N-(1,2-benzoisothiazolyl-3(2H)one-1,1-dioxide éthyl 5-éthoxycarbonyl-2,4,6-triméthyl-1,4-dihydropiridine-3-carboxylate dans le traitement des maladies vasculaires
CN114423785A (zh) 2019-07-01 2022-04-29 通尼克斯制药有限公司 抗-cd154抗体及其用途
EP4274587A1 (fr) 2021-01-06 2023-11-15 Tonix Pharma Limited Procédés pour induire une tolérance immunitaire avec des anticorps anti-cd154 modifiés

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ182325A (en) * 1975-11-18 1979-03-16 Beecham Group Ltd 2-substituted-1,2-benzisothiazol-3-ones
EP0000254B1 (fr) * 1977-06-20 1981-06-10 Beecham Group Plc 2-(Gamma-(1-piperidinyl)propyl)1,2-benzisothiazole 3-one antithrombotique, ses sels d'acides pharmaceutiquement acceptables, leur préparation et leurs compositions
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
AU561213B2 (en) * 1983-06-02 1987-04-30 Teijin Limited 1, 4-dihydropyridine derivative
JPS60120861A (ja) * 1983-12-02 1985-06-28 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体
DE3420784A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 3-nitro-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
JPS6143165A (ja) * 1984-08-07 1986-03-01 Otsuka Pharmaceut Co Ltd ジヒドロピリジン誘導体の製造法
GR851819B (fr) * 1984-08-17 1985-11-26 Wyeth John & Brother Ltd
US4757071A (en) * 1984-12-14 1988-07-12 Nisshin Flour Milling Co., Ltd. 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases

Also Published As

Publication number Publication date
DE3617976A1 (de) 1988-01-14
JPS62289578A (ja) 1987-12-16
PT84959A (en) 1987-06-01
EP0253092A1 (fr) 1988-01-20
MX163341A (es) 1992-04-24
CA1311481C (fr) 1992-12-15
EP0253092B1 (fr) 1991-09-25
US4782069A (en) 1988-11-01
ATA135687A (de) 1992-01-15
AT395011B (de) 1992-08-25
AR243185A1 (es) 1993-07-30
ES2004141A6 (es) 1988-12-01
GR870824B (en) 1987-09-30
DE3617976C2 (fr) 1989-05-03
PT84959B (pt) 1990-02-08
JPH0411547B2 (fr) 1992-02-28

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