ZA873029B - 1,4-disubstituted piperazine derivatives,pharmaceutical compositions containing them and process for preparing same - Google Patents
1,4-disubstituted piperazine derivatives,pharmaceutical compositions containing them and process for preparing sameInfo
- Publication number
- ZA873029B ZA873029B ZA873029A ZA873029A ZA873029B ZA 873029 B ZA873029 B ZA 873029B ZA 873029 A ZA873029 A ZA 873029A ZA 873029 A ZA873029 A ZA 873029A ZA 873029 B ZA873029 B ZA 873029B
- Authority
- ZA
- South Africa
- Prior art keywords
- group
- hydrogen
- stand
- different
- alkyl
- Prior art date
Links
- -1 1,4-disubstituted piperazine Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003291 dopaminomimetic effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU861749A HU196194B (en) | 1986-04-28 | 1986-04-28 | Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA873029B true ZA873029B (en) | 1987-10-02 |
Family
ID=10956001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA873029A ZA873029B (en) | 1986-04-28 | 1987-04-28 | 1,4-disubstituted piperazine derivatives,pharmaceutical compositions containing them and process for preparing same |
Country Status (14)
Country | Link |
---|---|
US (1) | US4874765A (fr) |
EP (1) | EP0243903B1 (fr) |
JP (1) | JPH0670026B2 (fr) |
AT (1) | ATE73786T1 (fr) |
AU (1) | AU599100B2 (fr) |
CA (1) | CA1308103C (fr) |
DE (1) | DE3777438D1 (fr) |
DK (1) | DK213187A (fr) |
ES (1) | ES2004408A6 (fr) |
FI (1) | FI85266C (fr) |
GR (1) | GR870665B (fr) |
HU (1) | HU196194B (fr) |
IL (1) | IL82352A0 (fr) |
ZA (1) | ZA873029B (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU196196B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds |
FR2601366B1 (fr) * | 1986-07-10 | 1988-11-25 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
ES2052890T3 (es) * | 1988-10-10 | 1994-07-16 | Akzo Nv | Un metodo para la sintesis de compuestos aromaticos di- y trisubstituidos. |
WO1991001732A1 (fr) * | 1989-08-03 | 1991-02-21 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Inhibiteurs de reabsorption de dopamine, serotonine ou norepinephrine de dissociation lente (liaison etroite) pris comme antagonistes de la cocaine, l'amphetamine et la phenecyclidine |
US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
DK178490D0 (da) * | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
DK178590D0 (da) * | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
SE9202266D0 (sv) * | 1992-07-31 | 1992-07-31 | Kabi Pharmacia Ab | Novel piperazine carboxamides |
DE19627411A1 (de) * | 1996-07-09 | 1998-01-15 | Bayer Ag | Verfahren zur Decarboxylierung halogenierter aromatischer Carbonsäuren |
US6743797B2 (en) * | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
US20050054010A1 (en) * | 2003-07-15 | 2005-03-10 | Brown Arthur M. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
US7211407B2 (en) * | 2003-07-15 | 2007-05-01 | Chan Test, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
US20050208595A1 (en) * | 2004-03-19 | 2005-09-22 | Brown Arthur M | High throughput assay systems and methods for identifying agents that alter expression of cellular proteins |
EP2671870A1 (fr) * | 2012-06-05 | 2013-12-11 | Bioprojet | Nouveaux dérivés d'éther (aza)benzhydryle, leur procédé de préparation et leur utilisation en tant que ligands du récepteur H4 pour applications thérapeutiques |
WO2014059367A1 (fr) * | 2012-10-11 | 2014-04-17 | Chanrx Corporation | Compositions pharmaceutiques contenant des mélanges racémiques et/ou énantiomériquement purs de composés de pipérazine chiraux et procédés d'arrêt d'épisodes aigus d'arythmie cardiaque, de rétablissement du rythme sinusal normal, de prévention de la récurrence de l'arythmie cardiaque et de maintien du rythme sinusal normal chez les mammifères par l'administration desdites compositions |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE551032A (fr) * | ||||
BE549420A (fr) * | ||||
US2988551A (en) * | 1954-07-30 | 1961-06-13 | Union Chimique Belge Sa | Piperazine derivatives |
GB837986A (en) * | 1956-07-10 | 1960-06-22 | Henri Morren | New piperazine derivatives and process for the preparation thereof |
JPS50142574A (fr) * | 1974-04-26 | 1975-11-17 | ||
FR2276824A1 (fr) * | 1974-07-04 | 1976-01-30 | Melon Jean Marie | Derives de la piperazine 1,4-disubstituee, leur procede de preparation et leurs applications therapeutiques |
GB1545094A (en) * | 1976-12-14 | 1979-05-02 | Gist Brocades Nv | Piperazine derivatives |
NL8202636A (nl) * | 1982-06-29 | 1984-01-16 | Gist Brocades Nv | Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten. |
HU196196B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds |
-
1986
- 1986-04-28 HU HU861749A patent/HU196194B/hu not_active IP Right Cessation
-
1987
- 1987-04-22 US US07/041,206 patent/US4874765A/en not_active Expired - Fee Related
- 1987-04-27 DK DK213187A patent/DK213187A/da not_active Application Discontinuation
- 1987-04-28 IL IL82352A patent/IL82352A0/xx not_active IP Right Cessation
- 1987-04-28 DE DE8787106032T patent/DE3777438D1/de not_active Expired - Fee Related
- 1987-04-28 ZA ZA873029A patent/ZA873029B/xx unknown
- 1987-04-28 JP JP62106155A patent/JPH0670026B2/ja not_active Expired - Lifetime
- 1987-04-28 ES ES8701260A patent/ES2004408A6/es not_active Expired
- 1987-04-28 EP EP87106032A patent/EP0243903B1/fr not_active Expired - Lifetime
- 1987-04-28 CA CA000535731A patent/CA1308103C/fr not_active Expired - Fee Related
- 1987-04-28 AT AT87106032T patent/ATE73786T1/de active
- 1987-04-28 AU AU72161/87A patent/AU599100B2/en not_active Ceased
- 1987-04-28 GR GR870665A patent/GR870665B/el unknown
- 1987-04-28 FI FI871874A patent/FI85266C/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI85266C (fi) | 1992-03-25 |
JPH0670026B2 (ja) | 1994-09-07 |
HU196194B (en) | 1988-10-28 |
DK213187D0 (da) | 1987-04-27 |
AU599100B2 (en) | 1990-07-12 |
IL82352A0 (en) | 1987-10-30 |
EP0243903B1 (fr) | 1992-03-18 |
GR870665B (en) | 1987-09-02 |
DE3777438D1 (de) | 1992-04-23 |
FI871874A0 (fi) | 1987-04-28 |
US4874765A (en) | 1989-10-17 |
DK213187A (da) | 1987-10-29 |
EP0243903A1 (fr) | 1987-11-04 |
AU7216187A (en) | 1987-10-29 |
CA1308103C (fr) | 1992-09-29 |
HUT45037A (en) | 1988-05-30 |
FI85266B (fi) | 1991-12-13 |
FI871874A (fi) | 1987-10-29 |
ATE73786T1 (de) | 1992-04-15 |
JPS62273969A (ja) | 1987-11-28 |
ES2004408A6 (es) | 1989-01-01 |
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