IL82352A0 - 1,4-disubstituted piperazine derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
1,4-disubstituted piperazine derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL82352A0 IL82352A0 IL82352A IL8235287A IL82352A0 IL 82352 A0 IL82352 A0 IL 82352A0 IL 82352 A IL82352 A IL 82352A IL 8235287 A IL8235287 A IL 8235287A IL 82352 A0 IL82352 A0 IL 82352A0
- Authority
- IL
- Israel
- Prior art keywords
- group
- hydrogen
- stand
- different
- alkyl
- Prior art date
Links
- -1 1,4-disubstituted piperazine Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000006193 alkinyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000003291 dopaminomimetic effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU861749A HU196194B (en) | 1986-04-28 | 1986-04-28 | Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL82352A0 true IL82352A0 (en) | 1987-10-30 |
Family
ID=10956001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL82352A IL82352A0 (en) | 1986-04-28 | 1987-04-28 | 1,4-disubstituted piperazine derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4874765A (xx) |
| EP (1) | EP0243903B1 (xx) |
| JP (1) | JPH0670026B2 (xx) |
| AT (1) | ATE73786T1 (xx) |
| AU (1) | AU599100B2 (xx) |
| CA (1) | CA1308103C (xx) |
| DE (1) | DE3777438D1 (xx) |
| DK (1) | DK213187A (xx) |
| ES (1) | ES2004408A6 (xx) |
| FI (1) | FI85266C (xx) |
| GR (1) | GR870665B (xx) |
| HU (1) | HU196194B (xx) |
| IL (1) | IL82352A0 (xx) |
| ZA (1) | ZA873029B (xx) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU196196B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds |
| FR2601366B1 (fr) * | 1986-07-10 | 1988-11-25 | Andre Buzas | Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant. |
| DE68903263T2 (de) * | 1988-10-10 | 1993-05-19 | Akzo Nv | Substituierte aromatische verbindungen mit zentraler nervensystem-wirkung. |
| CA2064574A1 (en) * | 1989-08-03 | 1991-02-04 | Richard B. Rothman | Slowly dissociating (tight binding) dopamine, serotonin or norepinephrine reuptake inhibitors as cocaine, amphetamine and phencyclidine antagonists |
| DK178490D0 (da) * | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
| US5276035A (en) * | 1990-07-26 | 1994-01-04 | Novo Nordisk A/S | 1,4-disubstituted piperazines |
| DK178590D0 (da) * | 1990-07-26 | 1990-07-26 | Novo Nordisk As | 1,4-disubstituerede piperaziner |
| SE9202266D0 (sv) * | 1992-07-31 | 1992-07-31 | Kabi Pharmacia Ab | Novel piperazine carboxamides |
| DE19627411A1 (de) * | 1996-07-09 | 1998-01-15 | Bayer Ag | Verfahren zur Decarboxylierung halogenierter aromatischer Carbonsäuren |
| US6743797B2 (en) | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
| US20050054010A1 (en) * | 2003-07-15 | 2005-03-10 | Brown Arthur M. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
| US7211407B2 (en) * | 2003-07-15 | 2007-05-01 | Chan Test, Inc. | High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins |
| US20050208595A1 (en) * | 2004-03-19 | 2005-09-22 | Brown Arthur M | High throughput assay systems and methods for identifying agents that alter expression of cellular proteins |
| EP2671870A1 (en) | 2012-06-05 | 2013-12-11 | Bioprojet | Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications |
| US20150290188A1 (en) * | 2012-10-11 | 2015-10-15 | Chanrx Corporation | Pharmaceutical compositions containing enantiomerically pure and/or racemic mixtures of chiral piperazine compounds and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals through administration of said compositions |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE549420A (xx) * | ||||
| BE551032A (xx) * | ||||
| US2988551A (en) * | 1954-07-30 | 1961-06-13 | Union Chimique Belge Sa | Piperazine derivatives |
| GB837986A (en) * | 1956-07-10 | 1960-06-22 | Henri Morren | New piperazine derivatives and process for the preparation thereof |
| JPS50142574A (xx) * | 1974-04-26 | 1975-11-17 | ||
| FR2276824A1 (fr) * | 1974-07-04 | 1976-01-30 | Melon Jean Marie | Derives de la piperazine 1,4-disubstituee, leur procede de preparation et leurs applications therapeutiques |
| GB1545094A (en) * | 1976-12-14 | 1979-05-02 | Gist Brocades Nv | Piperazine derivatives |
| NL8202636A (nl) * | 1982-06-29 | 1984-01-16 | Gist Brocades Nv | Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten. |
| HU196196B (en) * | 1986-04-28 | 1988-10-28 | Richter Gedeon Vegyeszet | Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds |
-
1986
- 1986-04-28 HU HU861749A patent/HU196194B/hu not_active IP Right Cessation
-
1987
- 1987-04-22 US US07/041,206 patent/US4874765A/en not_active Expired - Fee Related
- 1987-04-27 DK DK213187A patent/DK213187A/da not_active Application Discontinuation
- 1987-04-28 GR GR870665A patent/GR870665B/el unknown
- 1987-04-28 CA CA000535731A patent/CA1308103C/en not_active Expired - Fee Related
- 1987-04-28 AT AT87106032T patent/ATE73786T1/de active
- 1987-04-28 EP EP87106032A patent/EP0243903B1/de not_active Expired - Lifetime
- 1987-04-28 ES ES8701260A patent/ES2004408A6/es not_active Expired
- 1987-04-28 ZA ZA873029A patent/ZA873029B/xx unknown
- 1987-04-28 FI FI871874A patent/FI85266C/fi not_active IP Right Cessation
- 1987-04-28 JP JP62106155A patent/JPH0670026B2/ja not_active Expired - Lifetime
- 1987-04-28 DE DE8787106032T patent/DE3777438D1/de not_active Expired - Fee Related
- 1987-04-28 IL IL82352A patent/IL82352A0/xx not_active IP Right Cessation
- 1987-04-28 AU AU72161/87A patent/AU599100B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CA1308103C (en) | 1992-09-29 |
| FI85266C (fi) | 1992-03-25 |
| EP0243903A1 (de) | 1987-11-04 |
| HUT45037A (en) | 1988-05-30 |
| FI85266B (fi) | 1991-12-13 |
| AU7216187A (en) | 1987-10-29 |
| ZA873029B (en) | 1987-10-02 |
| ES2004408A6 (es) | 1989-01-01 |
| DK213187A (da) | 1987-10-29 |
| JPH0670026B2 (ja) | 1994-09-07 |
| AU599100B2 (en) | 1990-07-12 |
| DK213187D0 (da) | 1987-04-27 |
| DE3777438D1 (de) | 1992-04-23 |
| GR870665B (en) | 1987-09-02 |
| US4874765A (en) | 1989-10-17 |
| FI871874A0 (fi) | 1987-04-28 |
| HU196194B (en) | 1988-10-28 |
| JPS62273969A (ja) | 1987-11-28 |
| EP0243903B1 (de) | 1992-03-18 |
| ATE73786T1 (de) | 1992-04-15 |
| FI871874A (fi) | 1987-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |