FI871874A0 - Foerfarande foer framstaellning av 1,4-disubstituerade piperazinderivat. - Google Patents

Foerfarande foer framstaellning av 1,4-disubstituerade piperazinderivat.

Info

Publication number
FI871874A0
FI871874A0 FI871874A FI871874A FI871874A0 FI 871874 A0 FI871874 A0 FI 871874A0 FI 871874 A FI871874 A FI 871874A FI 871874 A FI871874 A FI 871874A FI 871874 A0 FI871874 A0 FI 871874A0
Authority
FI
Finland
Prior art keywords
group
hydrogen
stand
different
alkyl
Prior art date
Application number
FI871874A
Other languages
English (en)
Other versions
FI85266C (fi
FI85266B (fi
FI871874A (fi
Inventor
Edit Toth
Bela Kiss
Jozsef Torley
Eva Palosi
Istvan Hajdu
Laszlo Szporny
Dora Groo
Erzsebet Lapis
Istvan Laszlovszky
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of FI871874A0 publication Critical patent/FI871874A0/fi
Publication of FI871874A publication Critical patent/FI871874A/fi
Application granted granted Critical
Publication of FI85266B publication Critical patent/FI85266B/fi
Publication of FI85266C publication Critical patent/FI85266C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
FI871874A 1986-04-28 1987-04-28 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,4-disubstituerade piperazinderivat. FI85266C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU174986 1986-04-28
HU861749A HU196194B (en) 1986-04-28 1986-04-28 Process for producing new 1-4 disubstituted piperazines and pharmaceuticals comprising the compounds

Publications (4)

Publication Number Publication Date
FI871874A0 true FI871874A0 (fi) 1987-04-28
FI871874A FI871874A (fi) 1987-10-29
FI85266B FI85266B (fi) 1991-12-13
FI85266C FI85266C (fi) 1992-03-25

Family

ID=10956001

Family Applications (1)

Application Number Title Priority Date Filing Date
FI871874A FI85266C (fi) 1986-04-28 1987-04-28 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,4-disubstituerade piperazinderivat.

Country Status (14)

Country Link
US (1) US4874765A (fi)
EP (1) EP0243903B1 (fi)
JP (1) JPH0670026B2 (fi)
AT (1) ATE73786T1 (fi)
AU (1) AU599100B2 (fi)
CA (1) CA1308103C (fi)
DE (1) DE3777438D1 (fi)
DK (1) DK213187A (fi)
ES (1) ES2004408A6 (fi)
FI (1) FI85266C (fi)
GR (1) GR870665B (fi)
HU (1) HU196194B (fi)
IL (1) IL82352A0 (fi)
ZA (1) ZA873029B (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds
FR2601366B1 (fr) * 1986-07-10 1988-11-25 Andre Buzas Derives de la benzhydryloxyethyl-piperazine, procedes d'obtention et de compositions pharmaceutiques les contenant.
DE68903263T2 (de) * 1988-10-10 1993-05-19 Akzo Nv Substituierte aromatische verbindungen mit zentraler nervensystem-wirkung.
CA2064574A1 (en) * 1989-08-03 1991-02-04 Richard B. Rothman Slowly dissociating (tight binding) dopamine, serotonin or norepinephrine reuptake inhibitors as cocaine, amphetamine and phencyclidine antagonists
DK178490D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
US5276035A (en) * 1990-07-26 1994-01-04 Novo Nordisk A/S 1,4-disubstituted piperazines
DK178590D0 (da) * 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
SE9202266D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel piperazine carboxamides
DE19627411A1 (de) * 1996-07-09 1998-01-15 Bayer Ag Verfahren zur Decarboxylierung halogenierter aromatischer Carbonsäuren
US6743797B2 (en) 2002-02-22 2004-06-01 Chantest, Inc. Methods for treating cardiac arrhythmia
US20050054010A1 (en) * 2003-07-15 2005-03-10 Brown Arthur M. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US7211407B2 (en) * 2003-07-15 2007-05-01 Chan Test, Inc. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
US20050208595A1 (en) * 2004-03-19 2005-09-22 Brown Arthur M High throughput assay systems and methods for identifying agents that alter expression of cellular proteins
EP2671870A1 (en) 2012-06-05 2013-12-11 Bioprojet Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications
US20150290188A1 (en) * 2012-10-11 2015-10-15 Chanrx Corporation Pharmaceutical compositions containing enantiomerically pure and/or racemic mixtures of chiral piperazine compounds and methods of terminating acute episodes of cardiac arrhythmia, restoring normal sinus rhythm, preventing recurrence of cardiac arrhythmia and maintaining normal sinus rhythm in mammals through administration of said compositions

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE549420A (fi) *
BE551032A (fi) *
US2988551A (en) * 1954-07-30 1961-06-13 Union Chimique Belge Sa Piperazine derivatives
GB837986A (en) * 1956-07-10 1960-06-22 Henri Morren New piperazine derivatives and process for the preparation thereof
JPS50142574A (fi) * 1974-04-26 1975-11-17
FR2276824A1 (fr) * 1974-07-04 1976-01-30 Melon Jean Marie Derives de la piperazine 1,4-disubstituee, leur procede de preparation et leurs applications therapeutiques
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives
NL8202636A (nl) * 1982-06-29 1984-01-16 Gist Brocades Nv Piperazinederivaten, werkwijzen ter bereiding daarvan en farmaceutische preparaten die deze verbindingen bevatten.
HU196196B (en) * 1986-04-28 1988-10-28 Richter Gedeon Vegyeszet Process for producing new benzhydryl-piperazine derivatives and pharmaceuticals comprising the compounds

Also Published As

Publication number Publication date
CA1308103C (en) 1992-09-29
FI85266C (fi) 1992-03-25
EP0243903A1 (de) 1987-11-04
HUT45037A (en) 1988-05-30
FI85266B (fi) 1991-12-13
AU7216187A (en) 1987-10-29
IL82352A0 (en) 1987-10-30
ZA873029B (en) 1987-10-02
ES2004408A6 (es) 1989-01-01
DK213187A (da) 1987-10-29
JPH0670026B2 (ja) 1994-09-07
AU599100B2 (en) 1990-07-12
DK213187D0 (da) 1987-04-27
DE3777438D1 (de) 1992-04-23
GR870665B (en) 1987-09-02
US4874765A (en) 1989-10-17
HU196194B (en) 1988-10-28
JPS62273969A (ja) 1987-11-28
EP0243903B1 (de) 1992-03-18
ATE73786T1 (de) 1992-04-15
FI871874A (fi) 1987-10-29

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Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: RICHTER GEDEON VEGYESZETI GYAR RT