ZA868514B - New diphosphonic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents
New diphosphonic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing themInfo
- Publication number
- ZA868514B ZA868514B ZA868514A ZA868514A ZA868514B ZA 868514 B ZA868514 B ZA 868514B ZA 868514 A ZA868514 A ZA 868514A ZA 868514 A ZA868514 A ZA 868514A ZA 868514 B ZA868514 B ZA 868514B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- XQRLCLUYWUNEEH-UHFFFAOYSA-N diphosphonic acid Chemical class OP(=O)OP(O)=O XQRLCLUYWUNEEH-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- -1 Y is a valency bond Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000022458 calcium metabolism disease Diseases 0.000 abstract 1
- XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical class [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4025—Esters of poly(thio)phosphonic acids
- C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19853540150 DE3540150A1 (de) | 1985-11-13 | 1985-11-13 | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA868514B true ZA868514B (en) | 1987-07-29 |
Family
ID=6285806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA868514A ZA868514B (en) | 1985-11-13 | 1986-11-10 | New diphosphonic acid derivatives,processes for the preparation thereof and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4719203A (fi) |
| EP (1) | EP0224751B1 (fi) |
| JP (1) | JPS62114994A (fi) |
| AT (1) | ATE49766T1 (fi) |
| AU (1) | AU584759B2 (fi) |
| CA (1) | CA1289569C (fi) |
| CS (1) | CS258493B2 (fi) |
| DD (1) | DD255163A5 (fi) |
| DE (2) | DE3540150A1 (fi) |
| DK (1) | DK538686A (fi) |
| ES (1) | ES2014220B3 (fi) |
| FI (1) | FI864614A (fi) |
| HU (1) | HU195829B (fi) |
| IL (1) | IL80570A0 (fi) |
| ZA (1) | ZA868514B (fi) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| DE3770982D1 (de) * | 1986-04-24 | 1991-08-01 | Fujisawa Pharmaceutical Co | Diphosphonsaeure-verbindungen, verfahren zu deren herstellung und sie enthaltende arzneimittel. |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| ATE64397T1 (de) * | 1986-11-21 | 1991-06-15 | Ciba Geigy Ag | Aromatisch substituierte azacycloalkylalkandiphosphons|uren. |
| US4868164A (en) * | 1986-12-19 | 1989-09-19 | Norwich Eaton Pharmaceuticals, Inc. | Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism |
| US5071840A (en) * | 1986-12-19 | 1991-12-10 | Norwich Eaton Pharmaceuticals, Inc. | Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism |
| US4963681A (en) * | 1987-07-06 | 1990-10-16 | Norwich Eaton Pharmaceuticals, Inc. | Process for synthesis of aminomethylene phosphonoalkylphosphinates |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| US5190930A (en) * | 1987-12-11 | 1993-03-02 | Ciba-Geigy Corporation | Araliphatylaminoalkanediphosphonic acids |
| US5110807A (en) * | 1988-12-01 | 1992-05-05 | Ciba-Geigy Corporation | Araliphatylaminoalkanediphosphonic acids |
| CA1339805C (en) * | 1988-01-20 | 1998-04-07 | Yasuo Isomura | (cycloalkylamino)methylenebis(phosphonic acid) and medicines containing the same as an active |
| TW198039B (fi) * | 1988-11-28 | 1993-01-11 | Ciba Geigy Ag | |
| US5227506A (en) * | 1989-09-06 | 1993-07-13 | Merck & Co., Inc. | Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors |
| IE912115A1 (en) * | 1990-06-25 | 1992-01-01 | Takeda Chemical Industries Ltd | Bisphosphonic acid derivatives, their production and use |
| DE69108733T2 (de) * | 1990-08-21 | 1995-09-14 | Upjohn Co | Bisphosphonsäurederivate als antiarthritische mittel. |
| CA2058012A1 (en) * | 1990-12-19 | 1992-06-20 | Takashi Sohda | Bisphosphonic acid derivatives, their production and use |
| EP0541037A3 (en) * | 1991-11-06 | 1997-02-26 | Takeda Chemical Industries Ltd | Squalene synthetase inhibitory composition and use thereof |
| KR100192215B1 (ko) * | 1996-09-03 | 1999-06-15 | 강재헌 | 3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법 |
| US6677320B2 (en) | 2000-01-20 | 2004-01-13 | Hoffmann-La Roches Inc. | Parenteral bisphosphonate composition with improved local tolerance |
| PE20011061A1 (es) | 2000-02-01 | 2001-11-20 | Procter & Gamble | Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato |
| PE20011065A1 (es) | 2000-02-01 | 2001-11-21 | Procter & Gamble | Proceso para fabricar bisfosfonatos geminales |
| EP1284754B1 (en) | 2000-05-05 | 2006-01-04 | F. Hoffmann-La Roche Ag | Gel-like pharmaceutical composition for subcutaneous administration comprising bisphosphonic acids or their salts |
| KR100638122B1 (ko) * | 2001-12-21 | 2006-10-24 | 더 프록터 앤드 갬블 캄파니 | 골 장애의 치료 방법 |
| PT1506041E (pt) * | 2002-05-10 | 2007-12-28 | Hoffmann La Roche | Ácido ibandrónico para o tratamento e a prevenção da osteoporose |
| SI1790347T1 (sl) * | 2002-12-20 | 2015-03-31 | F. Hoffmann-La Roche Ag | Formulacija z visokim odmerkom ibandronata |
| SI2317852T1 (sl) | 2008-07-16 | 2015-04-30 | Richter Gedeon Nyrt. | Farmacevtske formulacije, ki vsebujejo ligande dopaminskega receptorja |
| HU229858B1 (en) | 2008-12-17 | 2014-10-28 | Richter Gedeon Nyrt | Process for the preparation of trans 4-amino-cyclohexyl acetic acid ethyl ester hcl |
| US8748097B1 (en) | 2011-12-02 | 2014-06-10 | President And Fellows Of Harvard College | Identification of agents for treating calcium disorders and uses thereof |
| PL407922A1 (pl) | 2014-04-16 | 2015-10-26 | Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością | Nowe bisfosfoniany i ich zastosowanie |
| TWI730039B (zh) | 2016-01-29 | 2021-06-11 | 日商富士藥品股份有限公司 | 新穎雙膦酸化合物 |
| US11274087B2 (en) | 2016-07-08 | 2022-03-15 | Richter Gedeon Nyrt. | Industrial process for the preparation of cariprazine |
| WO2019076269A1 (zh) | 2017-10-16 | 2019-04-25 | 清华大学 | 甲羟戊酸通路抑制剂及其药物组合物 |
| US11547707B2 (en) | 2019-04-10 | 2023-01-10 | Richter Gedeon Nyrt. | Carbamoyl cyclohexane derivatives for treating autism spectrum disorder |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1002355C2 (de) * | 1954-05-03 | 1957-07-25 | Thomae Gmbh Dr K | Verfahren zur Herstellung von ª‡-prim.-Amino-diphosphonsaeuren und deren Estern |
| DE1302557B (fi) * | 1963-04-09 | 1971-08-26 | ||
| FR96342E (fi) * | 1967-12-09 | 1972-06-16 | ||
| PH9853A (en) * | 1972-06-08 | 1976-04-13 | M Francis | Compositions for inhibiting mobilization of calcium phosphate in animal tissue and method of use thereof |
| DE2405254C2 (de) * | 1974-02-04 | 1982-05-27 | Henkel KGaA, 4000 Düsseldorf | Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper |
| DE2534391C2 (de) * | 1975-08-01 | 1983-01-13 | Henkel KGaA, 4000 Düsseldorf | 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren |
| DE2534390C2 (de) * | 1975-08-01 | 1983-01-13 | Henkel KGaA, 4000 Düsseldorf | 1,3-Di-aminoalkan-1,1-diphosphonsäuren |
| DE2745083C2 (de) * | 1977-10-07 | 1985-05-02 | Henkel KGaA, 4000 Düsseldorf | Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung |
| DE3016289A1 (de) * | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
| IT1201087B (it) * | 1982-04-15 | 1989-01-27 | Gentili Ist Spa | Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche |
| DE3428524A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3434667A1 (de) * | 1984-09-21 | 1986-04-03 | Henkel KGaA, 4000 Düsseldorf | 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung |
-
1985
- 1985-11-13 DE DE19853540150 patent/DE3540150A1/de not_active Withdrawn
-
1986
- 1986-11-07 DE DE8686115428T patent/DE3668459D1/de not_active Expired - Lifetime
- 1986-11-07 ES ES86115428T patent/ES2014220B3/es not_active Expired - Lifetime
- 1986-11-07 EP EP86115428A patent/EP0224751B1/de not_active Expired - Lifetime
- 1986-11-07 AT AT86115428T patent/ATE49766T1/de not_active IP Right Cessation
- 1986-11-10 ZA ZA868514A patent/ZA868514B/xx unknown
- 1986-11-10 IL IL80570A patent/IL80570A0/xx unknown
- 1986-11-10 DD DD86296129A patent/DD255163A5/de unknown
- 1986-11-11 CS CS868154A patent/CS258493B2/cs unknown
- 1986-11-11 DK DK538686A patent/DK538686A/da not_active Application Discontinuation
- 1986-11-12 US US06/930,331 patent/US4719203A/en not_active Expired - Lifetime
- 1986-11-12 AU AU65090/86A patent/AU584759B2/en not_active Ceased
- 1986-11-12 HU HU864676A patent/HU195829B/hu not_active IP Right Cessation
- 1986-11-12 FI FI864614A patent/FI864614A/fi not_active Application Discontinuation
- 1986-11-12 JP JP61267906A patent/JPS62114994A/ja active Pending
- 1986-11-12 CA CA000522806A patent/CA1289569C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL80570A0 (en) | 1987-02-27 |
| HU195829B (en) | 1988-07-28 |
| AU6509086A (en) | 1987-05-21 |
| AU584759B2 (en) | 1989-06-01 |
| FI864614A (fi) | 1987-05-14 |
| CA1289569C (en) | 1991-09-24 |
| DK538686D0 (da) | 1986-11-11 |
| JPS62114994A (ja) | 1987-05-26 |
| DD255163A5 (de) | 1988-03-23 |
| ATE49766T1 (de) | 1990-02-15 |
| CS258493B2 (en) | 1988-08-16 |
| CS815486A2 (en) | 1987-12-17 |
| US4719203A (en) | 1988-01-12 |
| HUT42496A (en) | 1987-07-28 |
| EP0224751B1 (de) | 1990-01-24 |
| DK538686A (da) | 1987-05-14 |
| DE3540150A1 (de) | 1987-05-14 |
| DE3668459D1 (de) | 1990-03-01 |
| EP0224751A1 (de) | 1987-06-10 |
| FI864614A0 (fi) | 1986-11-12 |
| ES2014220B3 (es) | 1990-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU584759B2 (en) | New diphosphonic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | |
| PT85301A (de) | Neue diphosphonsaeurederivate verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel | |
| ES8604724A1 (es) | Un procedimiento para la preparacion de derivados de piperi-dina |