ES8604724A1 - Un procedimiento para la preparacion de derivados de piperi-dina - Google Patents

Un procedimiento para la preparacion de derivados de piperi-dina

Info

Publication number
ES8604724A1
ES8604724A1 ES540346A ES540346A ES8604724A1 ES 8604724 A1 ES8604724 A1 ES 8604724A1 ES 540346 A ES540346 A ES 540346A ES 540346 A ES540346 A ES 540346A ES 8604724 A1 ES8604724 A1 ES 8604724A1
Authority
ES
Spain
Prior art keywords
phenyl
optionally substituted
alkoxy
alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES540346A
Other languages
English (en)
Other versions
ES540346A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Wuelfing GmbH and Co KG
Original Assignee
Beecham Wuelfing GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838307081A external-priority patent/GB8307081D0/en
Application filed by Beecham Wuelfing GmbH and Co KG filed Critical Beecham Wuelfing GmbH and Co KG
Publication of ES540346A0 publication Critical patent/ES540346A0/es
Publication of ES8604724A1 publication Critical patent/ES8604724A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIPERIDINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN CONDICIONES CONVENCIONALES PARA LOS REACTIVOS DE GRIGNARD CON TEMPERATURAS ENTRE LA TEMPERATURA AMBIENTE Y C25JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) O SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: AR FENILO O NAFTILO OPCIONALMENTE SUSTITUIDOS, Y OTROS; E ES O, S O UN ENLACE; J1 ES UN ENLACE O POLIMETILENO C 1 A 2; J2 ES POLIMETILENO C 1 A 4 OPCIONALMENTE SUSTITUIDO; J11 ES J1 CON TODOS LOS GRUPOS HIDROXI PROTEGIDOS; J21 ES J2 CON TODOS LOS GRUPOS HIDROXI PROTEGIDOS; M ES UN GRUPO HALOMAGNESIO (II) O LI; R1 Y R4 SON H, ALQUILO C 1 A 4 Y OTROS; R5 ES H; R12 ES UN GRUPO PROTECTOR DEL NITROGENO; RQ ES R1 O BENCILO OPCIONALMENTE SUSTITUIDO; Y T ES H O METILO. SE UTILIZA PARA EL TRATAMIENTO O PROFILAXIS DE ARRITMIAS CARDIACAS.
ES540346A 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina Expired ES8604724A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8216911 1982-06-10
GB8218407 1982-06-25
GB838307081A GB8307081D0 (en) 1983-03-15 1983-03-15 Amine derivatives

Publications (2)

Publication Number Publication Date
ES540346A0 ES540346A0 (es) 1985-12-01
ES8604724A1 true ES8604724A1 (es) 1985-12-01

Family

ID=27261622

Family Applications (9)

Application Number Title Priority Date Filing Date
ES523136A Expired ES8503652A1 (es) 1982-06-10 1983-06-09 Un procedimiento para la preparacion de un compuesto.
ES540340A Granted ES540340A0 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540345A Expired ES8604723A1 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540346A Expired ES8604724A1 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540343A Granted ES540343A0 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540347A Expired ES8604725A1 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540344A Expired ES8604722A1 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540341A Granted ES540341A0 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540342A Expired ES8604720A1 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES523136A Expired ES8503652A1 (es) 1982-06-10 1983-06-09 Un procedimiento para la preparacion de un compuesto.
ES540340A Granted ES540340A0 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540345A Expired ES8604723A1 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES540343A Granted ES540343A0 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540347A Expired ES8604725A1 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540344A Expired ES8604722A1 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540341A Granted ES540341A0 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina
ES540342A Expired ES8604720A1 (es) 1982-06-10 1985-02-12 Un procedimiento para la preparacion de derivados de piperi-dina

Country Status (7)

Country Link
US (1) US4603138A (es)
EP (1) EP0097000B1 (es)
AU (1) AU566485B2 (es)
DE (1) DE3373466D1 (es)
ES (9) ES8503652A1 (es)
IE (1) IE55387B1 (es)
NZ (1) NZ204490A (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0207036A1 (en) * 1985-06-20 1986-12-30 Aktiebolaget Hässle New para-substituted 3-phenoxy-1-piperidinecarbonylaminoalkylamino-propanol-2-s having beta receptor blocking properties.
DE4032767A1 (de) * 1990-10-16 1992-04-30 Basf Ag Phenylpiperidinoylamine und diese enthaltende arzneimittel
DE4032766A1 (de) * 1990-10-16 1992-04-30 Basf Ag Phenylpiperidinoylamine und diese enthaltende arzneimittel
DE59204456D1 (de) * 1991-03-14 1996-01-11 Basf Ag Substituierte N-Phenylpiperidine und Arzneimittel daraus.
DE4117904A1 (de) * 1991-05-31 1992-12-03 Basf Ag Substituierte n-phenylpiperidine
US5656642A (en) * 1993-04-07 1997-08-12 Otsuka Pharmaceutical Co., Ltd. Peripheral vasodilating agent containing piperidine derivative as active ingredient
MY142362A (en) 2004-01-29 2010-11-30 Otsuka Pharma Co Ltd Pharmaceutical composition for promoting angiogenesis

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3147268A (en) * 1961-09-25 1964-09-01 Warner Lambert Pharmaceutical 4-amino derivatives of methylpiperidines
CH436289A (de) * 1964-03-26 1967-05-31 Sandoz Ag Verfahren zur Herstellung neuer heterocyclischer Verbindungen
US3531487A (en) * 1966-10-25 1970-09-29 Hoffmann La Roche 4-(n,n-disubstituted-amino)-piperidines
SE368197B (es) * 1968-11-18 1974-06-24 Pfizer
US3992389A (en) * 1970-09-03 1976-11-16 John Wyeth & Brother Limited Heterocyclic compounds
HU169464B (es) * 1974-02-20 1976-11-28
US4379167A (en) * 1974-10-25 1983-04-05 A. H. Robins Company, Inc. 1-Aryloxy-4-amino-2-butanols and the pharmaceutical use thereof
US4001328A (en) * 1975-06-04 1977-01-04 Eli Lilly And Company Diarylbutanolamines
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4463190A (en) * 1977-07-05 1984-07-31 A. H. Robins Company, Inc. 1-Aryloxy-4-amino-2-butanols
DE2825961A1 (de) * 1978-06-14 1980-01-03 Basf Ag Fungizide amine
EP0029707B1 (en) * 1979-11-21 1984-02-01 Kyowa Hakko Kogyo Co., Ltd Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them
US4499100A (en) * 1983-05-18 1985-02-12 Syntex (U.S.A.) Inc. Benzodioxanyl-hydroxyethyleneamino-piperidinyl acetanilides, ketones, esters and carbamates which effect immunity and calcium entry and β-blockade

Also Published As

Publication number Publication date
EP0097000A3 (en) 1984-12-27
EP0097000A2 (en) 1983-12-28
ES8604718A1 (es) 1985-12-01
IE55387B1 (en) 1990-08-29
DE3373466D1 (de) 1987-10-15
NZ204490A (en) 1986-09-10
AU566485B2 (en) 1987-10-22
ES540345A0 (es) 1985-12-01
ES8604721A1 (es) 1985-12-01
ES8604719A1 (es) 1985-12-01
ES523136A0 (es) 1985-03-01
ES540346A0 (es) 1985-12-01
IE831349L (en) 1983-12-10
AU1549683A (en) 1983-12-15
ES540341A0 (es) 1985-12-01
ES540344A0 (es) 1985-12-01
ES540347A0 (es) 1985-12-01
ES540342A0 (es) 1985-12-01
ES8604720A1 (es) 1985-12-01
EP0097000B1 (en) 1987-09-09
US4603138A (en) 1986-07-29
ES8503652A1 (es) 1985-03-01
ES8604722A1 (es) 1985-12-01
ES8604725A1 (es) 1985-12-01
ES540343A0 (es) 1985-12-01
ES540340A0 (es) 1985-12-01
ES8604723A1 (es) 1985-12-01

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