ES8604725A1 - Un procedimiento para la preparacion de derivados de piperi-dina - Google Patents
Un procedimiento para la preparacion de derivados de piperi-dinaInfo
- Publication number
- ES8604725A1 ES8604725A1 ES540347A ES540347A ES8604725A1 ES 8604725 A1 ES8604725 A1 ES 8604725A1 ES 540347 A ES540347 A ES 540347A ES 540347 A ES540347 A ES 540347A ES 8604725 A1 ES8604725 A1 ES 8604725A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- optionally substituted
- alkoxy
- alkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PIPERIDINA. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III) EN CONDICIONES CONVENCIONALES PARA LOS REACTIVOS DE GRIGNARD A UNA TEMPERATURA ENTRE C15JC Y LA TEMPERATURA AMBIENTE, PARA OBTENER UN COMPUESTO DE FORMULA (I) O SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO: AR FENILO O NAFTILO OPCIONALMENTE SUSTITUIDOS, Y OTROS; E ES O, S O UN ENLACE; J1 ES UN ENLACE O POLIMETILENO C 1 A 2; J2 ES POLIMETILENO C 1 A 4; J3 ES UN ENLACE Y OTROS; J11 ES J1 CON TODOS LOS GRUPOS HIDROXI PROTEGIDOS; J21 ES J2 CON TODOS LOS GRUPOS HIDROXI PROTEGIDOS; M ES HALOMAGNESIO (II) O LI; R1 ES H, ALQUILO C 1 A 4 Y OTROS; R5 ES H Y OTROS; R12 ES UN GRUPO PROTECTOR DE NITROGENO; RQ ES R1 O BENCILO OPCIONALMENTE PROTEGIDO. SE UTILIZA PARA EL TRATAMIENTO O PROFILAXIS DE ARRITMIAS CARDIACAS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8216911 | 1982-06-10 | ||
GB8218407 | 1982-06-25 | ||
GB838307081A GB8307081D0 (en) | 1983-03-15 | 1983-03-15 | Amine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES540347A0 ES540347A0 (es) | 1985-12-01 |
ES8604725A1 true ES8604725A1 (es) | 1985-12-01 |
Family
ID=27261622
Family Applications (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES523136A Expired ES8503652A1 (es) | 1982-06-10 | 1983-06-09 | Un procedimiento para la preparacion de un compuesto. |
ES540345A Expired ES8604723A1 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540347A Expired ES8604725A1 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540342A Granted ES540342A0 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540340A Expired ES8604718A1 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540344A Granted ES540344A0 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540341A Expired ES8604719A1 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540346A Granted ES540346A0 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540343A Granted ES540343A0 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES523136A Expired ES8503652A1 (es) | 1982-06-10 | 1983-06-09 | Un procedimiento para la preparacion de un compuesto. |
ES540345A Expired ES8604723A1 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES540342A Granted ES540342A0 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540340A Expired ES8604718A1 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540344A Granted ES540344A0 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540341A Expired ES8604719A1 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540346A Granted ES540346A0 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
ES540343A Granted ES540343A0 (es) | 1982-06-10 | 1985-02-12 | Un procedimiento para la preparacion de derivados de piperi-dina |
Country Status (7)
Country | Link |
---|---|
US (1) | US4603138A (es) |
EP (1) | EP0097000B1 (es) |
AU (1) | AU566485B2 (es) |
DE (1) | DE3373466D1 (es) |
ES (9) | ES8503652A1 (es) |
IE (1) | IE55387B1 (es) |
NZ (1) | NZ204490A (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0207036A1 (en) * | 1985-06-20 | 1986-12-30 | Aktiebolaget Hässle | New para-substituted 3-phenoxy-1-piperidinecarbonylaminoalkylamino-propanol-2-s having beta receptor blocking properties. |
DE4032767A1 (de) * | 1990-10-16 | 1992-04-30 | Basf Ag | Phenylpiperidinoylamine und diese enthaltende arzneimittel |
DE4032766A1 (de) * | 1990-10-16 | 1992-04-30 | Basf Ag | Phenylpiperidinoylamine und diese enthaltende arzneimittel |
DE4117904A1 (de) * | 1991-05-31 | 1992-12-03 | Basf Ag | Substituierte n-phenylpiperidine |
EP0503411B1 (de) * | 1991-03-14 | 1995-11-29 | BASF Aktiengesellschaft | Substituierte N-Phenylpiperidine und Arzneimittel daraus |
WO1994022826A1 (en) * | 1993-04-07 | 1994-10-13 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing n-acylated 4-amino piperidine derivatives as active ingredients |
MY142362A (en) | 2004-01-29 | 2010-11-30 | Otsuka Pharma Co Ltd | Pharmaceutical composition for promoting angiogenesis |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3147268A (en) * | 1961-09-25 | 1964-09-01 | Warner Lambert Pharmaceutical | 4-amino derivatives of methylpiperidines |
CH436289A (de) * | 1964-03-26 | 1967-05-31 | Sandoz Ag | Verfahren zur Herstellung neuer heterocyclischer Verbindungen |
US3531487A (en) * | 1966-10-25 | 1970-09-29 | Hoffmann La Roche | 4-(n,n-disubstituted-amino)-piperidines |
DE1957706C3 (de) * | 1968-11-18 | 1978-06-29 | Pfizer Corp., Colon (Panama) | Kernsubstituierte 3-Phenoxy-l-phenoxyalkylamino-propan-2-ole und Arzneimittel auf deren Basis |
US3992389A (en) * | 1970-09-03 | 1976-11-16 | John Wyeth & Brother Limited | Heterocyclic compounds |
HU169464B (es) * | 1974-02-20 | 1976-11-28 | ||
US4379167A (en) * | 1974-10-25 | 1983-04-05 | A. H. Robins Company, Inc. | 1-Aryloxy-4-amino-2-butanols and the pharmaceutical use thereof |
US4001328A (en) * | 1975-06-04 | 1977-01-04 | Eli Lilly And Company | Diarylbutanolamines |
DE2711655A1 (de) * | 1977-03-17 | 1978-09-21 | Basf Ag | Pyridinyl-aminoalkylaether |
US4463190A (en) * | 1977-07-05 | 1984-07-31 | A. H. Robins Company, Inc. | 1-Aryloxy-4-amino-2-butanols |
DE2825961A1 (de) * | 1978-06-14 | 1980-01-03 | Basf Ag | Fungizide amine |
DE3066434D1 (en) * | 1979-11-21 | 1984-03-08 | Kyowa Hakko Kogyo Kk | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them |
US4499100A (en) * | 1983-05-18 | 1985-02-12 | Syntex (U.S.A.) Inc. | Benzodioxanyl-hydroxyethyleneamino-piperidinyl acetanilides, ketones, esters and carbamates which effect immunity and calcium entry and β-blockade |
-
1983
- 1983-06-02 EP EP83303168A patent/EP0097000B1/en not_active Expired
- 1983-06-02 DE DE8383303168T patent/DE3373466D1/de not_active Expired
- 1983-06-08 IE IE1349/83A patent/IE55387B1/en unknown
- 1983-06-08 AU AU15496/83A patent/AU566485B2/en not_active Ceased
- 1983-06-08 NZ NZ204490A patent/NZ204490A/en unknown
- 1983-06-09 US US06/502,673 patent/US4603138A/en not_active Expired - Fee Related
- 1983-06-09 ES ES523136A patent/ES8503652A1/es not_active Expired
-
1985
- 1985-02-12 ES ES540345A patent/ES8604723A1/es not_active Expired
- 1985-02-12 ES ES540347A patent/ES8604725A1/es not_active Expired
- 1985-02-12 ES ES540342A patent/ES540342A0/es active Granted
- 1985-02-12 ES ES540340A patent/ES8604718A1/es not_active Expired
- 1985-02-12 ES ES540344A patent/ES540344A0/es active Granted
- 1985-02-12 ES ES540341A patent/ES8604719A1/es not_active Expired
- 1985-02-12 ES ES540346A patent/ES540346A0/es active Granted
- 1985-02-12 ES ES540343A patent/ES540343A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
ES523136A0 (es) | 1985-03-01 |
EP0097000A3 (en) | 1984-12-27 |
DE3373466D1 (de) | 1987-10-15 |
ES8604724A1 (es) | 1985-12-01 |
NZ204490A (en) | 1986-09-10 |
EP0097000A2 (en) | 1983-12-28 |
ES540346A0 (es) | 1985-12-01 |
ES540340A0 (es) | 1985-12-01 |
ES540347A0 (es) | 1985-12-01 |
ES540345A0 (es) | 1985-12-01 |
US4603138A (en) | 1986-07-29 |
ES8604720A1 (es) | 1985-12-01 |
AU1549683A (en) | 1983-12-15 |
IE55387B1 (en) | 1990-08-29 |
ES540342A0 (es) | 1985-12-01 |
ES8503652A1 (es) | 1985-03-01 |
EP0097000B1 (en) | 1987-09-09 |
ES8604722A1 (es) | 1985-12-01 |
ES8604721A1 (es) | 1985-12-01 |
AU566485B2 (en) | 1987-10-22 |
ES540341A0 (es) | 1985-12-01 |
ES8604718A1 (es) | 1985-12-01 |
ES8604723A1 (es) | 1985-12-01 |
ES8604719A1 (es) | 1985-12-01 |
ES540344A0 (es) | 1985-12-01 |
ES540343A0 (es) | 1985-12-01 |
IE831349L (en) | 1983-12-10 |
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