ZA867424B - Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1h,3h)diones methods of preparation,compositions and method of use - Google Patents

Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1h,3h)diones methods of preparation,compositions and method of use

Info

Publication number
ZA867424B
ZA867424B ZA867424A ZA867424A ZA867424B ZA 867424 B ZA867424 B ZA 867424B ZA 867424 A ZA867424 A ZA 867424A ZA 867424 A ZA867424 A ZA 867424A ZA 867424 B ZA867424 B ZA 867424B
Authority
ZA
South Africa
Prior art keywords
alkylquinazolin
diones
piperazinyl
phenyl
substituted
Prior art date
Application number
ZA867424A
Other languages
English (en)
Inventor
Victor T Bandurco
Charles F Schwender
Robert Falotico
Alfonso J Tobia
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of ZA867424B publication Critical patent/ZA867424B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA867424A 1985-09-30 1986-09-29 Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1h,3h)diones methods of preparation,compositions and method of use ZA867424B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/782,241 US4711883A (en) 1985-09-30 1985-09-30 Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use

Publications (1)

Publication Number Publication Date
ZA867424B true ZA867424B (en) 1988-04-27

Family

ID=25125457

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA867424A ZA867424B (en) 1985-09-30 1986-09-29 Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1h,3h)diones methods of preparation,compositions and method of use

Country Status (15)

Country Link
US (1) US4711883A (fr)
EP (1) EP0219259A3 (fr)
JP (1) JPS62111970A (fr)
KR (1) KR870003098A (fr)
AU (1) AU583949B2 (fr)
CA (1) CA1290334C (fr)
DK (3) DK162988C (fr)
ES (1) ES2001809A6 (fr)
FI (1) FI863910A (fr)
GR (1) GR862452B (fr)
HU (1) HUT43590A (fr)
IL (1) IL80184A0 (fr)
NO (1) NO863870L (fr)
PT (1) PT83458B (fr)
ZA (1) ZA867424B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
PL165856B1 (pl) * 1990-04-24 1995-02-28 Dresden Arzneimittel Sposób wytwarzania nowych 3-/merkaptoalkilo/-chinazolino-/1 H,3H/-dionów-2,4 PL
IE913473A1 (en) * 1990-10-15 1992-04-22 Fujisawa Pharmaceutical Co Quinazoline derivatives and their preparation
KR100817538B1 (ko) * 2006-07-05 2008-03-27 한국화학연구원 신규 치환된―１ｈ―퀴나졸린―２,４―디온 유도체, 이의제조방법 및 이를 함유하는 약학적 조성물
KR101705727B1 (ko) * 2009-02-26 2017-02-10 레비바 파마슈티칼스, 아이엔씨. 아릴피페라진 유도체의 조성물, 합성, 및 사용 방법
EP3180318B1 (fr) * 2014-08-11 2019-02-20 Hydra Biosciences, Inc. Dérivés quinazoline-2,4(1h,3h)-dione en tant que modulateurs trcp5 pour le traitement de maladies neuropsychiatriques
CN111848528B (zh) * 2019-04-29 2022-03-11 北京嘉林药业股份有限公司 一种预防和/或治疗癌症的化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612466A (en) * 1966-05-26 1967-11-30 Miles Laboratories Inc. V Product and process
US3819630A (en) * 1972-08-21 1974-06-25 R Parcell 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
JPS58159480A (ja) * 1982-03-17 1983-09-21 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
JPS6187675A (ja) * 1984-10-05 1986-05-06 Mitsubishi Chem Ind Ltd キナゾリン誘導体およびその酸付加塩
JPS61161268A (ja) * 1985-01-08 1986-07-21 Mitsubishi Chem Ind Ltd フエニルピペラジン誘導体
JPS60222467A (ja) * 1984-04-17 1985-11-07 Mitsubishi Chem Ind Ltd キナゾリン誘導体およびそれらの酸付加塩
US4639518A (en) * 1984-09-24 1987-01-27 Ortho Pharmaceutical Corporation Substituted quinazolinediones

Also Published As

Publication number Publication date
HUT43590A (en) 1987-11-30
CA1290334C (fr) 1991-10-08
FI863910A (fi) 1987-03-31
FI863910A0 (fi) 1986-09-29
DK113591A (da) 1991-06-13
PT83458A (en) 1986-10-01
AU583949B2 (en) 1989-05-11
DK109891D0 (da) 1991-06-10
DK162988C (da) 1992-06-01
DK465086A (da) 1987-03-31
IL80184A0 (en) 1986-12-31
DK162988B (da) 1992-01-06
EP0219259A3 (fr) 1988-01-20
ES2001809A6 (es) 1988-06-16
DK113591D0 (da) 1991-06-13
NO863870L (no) 1987-03-31
GR862452B (en) 1987-01-27
DK109891A (da) 1991-06-10
JPS62111970A (ja) 1987-05-22
EP0219259A2 (fr) 1987-04-22
PT83458B (en) 1988-10-31
KR870003098A (ko) 1987-04-15
AU6321186A (en) 1987-04-02
NO863870D0 (no) 1986-09-29
US4711883A (en) 1987-12-08
DK465086D0 (da) 1986-09-29

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