ZA864522B - N-substituted-arylalkyl and arylalkylene aminoheterocyclics as cardiovascular antihistaminic and antisecretory agents - Google Patents

N-substituted-arylalkyl and arylalkylene aminoheterocyclics as cardiovascular antihistaminic and antisecretory agents

Info

Publication number
ZA864522B
ZA864522B ZA864522A ZA864522A ZA864522B ZA 864522 B ZA864522 B ZA 864522B ZA 864522 A ZA864522 A ZA 864522A ZA 864522 A ZA864522 A ZA 864522A ZA 864522 B ZA864522 B ZA 864522B
Authority
ZA
South Africa
Prior art keywords
aminoheterocyclics
antihistaminic
arylalkylene
arylalkyl
cardiovascular
Prior art date
Application number
ZA864522A
Other languages
English (en)
Inventor
James Robert Shanklin Jr
Anthony George Proakis
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of ZA864522B publication Critical patent/ZA864522B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA864522A 1986-01-17 1986-06-17 N-substituted-arylalkyl and arylalkylene aminoheterocyclics as cardiovascular antihistaminic and antisecretory agents ZA864522B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81970186A 1986-01-17 1986-01-17

Publications (1)

Publication Number Publication Date
ZA864522B true ZA864522B (en) 1987-02-25

Family

ID=25228814

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA864522A ZA864522B (en) 1986-01-17 1986-06-17 N-substituted-arylalkyl and arylalkylene aminoheterocyclics as cardiovascular antihistaminic and antisecretory agents

Country Status (11)

Country Link
JP (1) JPH0772171B2 (xx)
KR (1) KR900005368B1 (xx)
AU (1) AU594972B2 (xx)
DK (1) DK347986A (xx)
GR (1) GR862024B (xx)
IL (1) IL78939A (xx)
IN (1) IN163948B (xx)
NZ (1) NZ217408A (xx)
PH (3) PH23843A (xx)
PT (1) PT84128B (xx)
ZA (1) ZA864522B (xx)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004051A1 (en) 1993-07-30 1995-02-09 The Wellcome Foundation Limited Piperazine compounds used in therapy
US5432175A (en) * 1990-10-10 1995-07-11 Schering Corporation Pyridine and pyridine N-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
US5561117A (en) * 1992-03-27 1996-10-01 Schering Corporation Bridged bis-aryl carbinol derivatives, compositions and methods of use
US5679692A (en) * 1992-03-27 1997-10-21 Schering Corporation Unbridged bis-aryl carbinol derivatives, compositions and methods of use
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US6004980A (en) * 1990-06-01 1999-12-21 Merrell Pharmaceuticals, Inc. (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof
KR890012971A (ko) * 1988-02-10 1989-09-20 원본미기재 심장혈관 항히스타민제 및 분비억제제로서의 n-치환된-아릴알킬 및 아릴알킬렌 아미노헤테로사이클릭 화합물
AU629534B2 (en) * 1988-02-24 1992-10-08 A.H. Robins Company, Incorporated New methods and related compounds
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
GB8928042D0 (en) * 1989-12-12 1990-02-14 Pfizer Ltd Muscarinic receptor antagonists
DE4111861A1 (de) * 1991-04-11 1992-10-15 Schwabe Willmar Gmbh & Co Benzopyranone, verfahren zu ihrer herstellung und verwendung
WO1993011108A1 (en) * 1991-11-29 1993-06-10 Zeria Pharmaceutical Co., Ltd. Piperidine derivative and medicine containing the same
JP4057088B2 (ja) * 1996-04-22 2008-03-05 株式会社カネカ ピロリジン誘導体の製造方法
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035372A (en) * 1976-08-13 1977-07-12 G. D. Searle & Co. 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines
US4632925A (en) * 1985-10-07 1986-12-30 Hoffmann-La Roche Inc. N-substituted diphenylpiperidines and antiobesity use thereof
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004980A (en) * 1990-06-01 1999-12-21 Merrell Pharmaceuticals, Inc. (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
US5432175A (en) * 1990-10-10 1995-07-11 Schering Corporation Pyridine and pyridine N-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
US5561117A (en) * 1992-03-27 1996-10-01 Schering Corporation Bridged bis-aryl carbinol derivatives, compositions and methods of use
US5679692A (en) * 1992-03-27 1997-10-21 Schering Corporation Unbridged bis-aryl carbinol derivatives, compositions and methods of use
WO1995004051A1 (en) 1993-07-30 1995-02-09 The Wellcome Foundation Limited Piperazine compounds used in therapy
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol

Also Published As

Publication number Publication date
PH24983A (en) 1990-12-26
NZ217408A (en) 1990-03-27
IL78939A (en) 1990-04-29
KR870007131A (ko) 1987-08-17
KR900005368B1 (ko) 1990-07-28
PT84128B (pt) 1989-05-31
JPS62169763A (ja) 1987-07-25
DK347986D0 (da) 1986-07-22
AU6247386A (en) 1987-07-23
DK347986A (da) 1987-07-18
PT84128A (en) 1987-02-01
GR862024B (en) 1986-12-24
AU594972B2 (en) 1990-03-22
PH24904A (en) 1990-12-26
IN163948B (xx) 1988-12-10
PH23843A (en) 1989-11-23
JPH0772171B2 (ja) 1995-08-02
IL78939A0 (en) 1986-09-30

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