PT84128A - Process for the preparation of n-substituted-arylalkyl and arylalkylene aminometero cyclic compounds - Google Patents

Process for the preparation of n-substituted-arylalkyl and arylalkylene aminometero cyclic compounds

Info

Publication number
PT84128A
PT84128A PT84128A PT8412887A PT84128A PT 84128 A PT84128 A PT 84128A PT 84128 A PT84128 A PT 84128A PT 8412887 A PT8412887 A PT 8412887A PT 84128 A PT84128 A PT 84128A
Authority
PT
Portugal
Prior art keywords
alkyl
coor1
bond
conr1r2
cor1
Prior art date
Application number
PT84128A
Other languages
Portuguese (pt)
Other versions
PT84128B (en
Inventor
James Robert Shanklin Jr
Anthony George Proakis
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of PT84128A publication Critical patent/PT84128A/en
Publication of PT84128B publication Critical patent/PT84128B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

(1) N-Aryl-pyrrolidine, -piperidine and -homopiperidine derivs. of formula (I) and their acid-addn. and quat. salts and their hydrates and alcoholates are new. p = 0, 1 or 2; A = H, OR1, CN, CONR1R2, COR1, COOR1, OCOR1, CH2OR1 or CH2NR1R2; m = 0-6; Q = CH, CH2 or CH(OH); d, n = 0 or 1 and the dotted lines are opt. double bonds; Ar = X,Y,ZC6H2, pyridyl, thienyl, furyl or naphthyl; R = Ar gp., X,Y,ZC6H2CH2, cycloalkyl or 1-8C alkyl; D = Ar gp., quinolyl, Ar(CH2)5 or a gp. of formulae (II)-(IV). In (III) when X = H, bond a may be a single bond; s = 1-4; t = 0, 1 or 2; X,Y,Z = H, 1-8C alkyl, halogen, NO2, OR1, COR1, CF3, CN, CONR1R1, NR1R1, COOR1, SO2R2, SR2, SOR2, NR1-COR2, CH2COOM, SO2NR1R2, NR1-SO2Me, NR1-CONR1R2 or NR1-COOR2; B = O, S, SO, SO2, NR1 or N-COOR1; z = 0 or 1, but it is not 0 when n = 0 and D = opt. substd. Ph, or (A)d = H or CN or aminocarbonyl, or a there is a double bond between the alpha C atom and a C atom of the pyrrolidino etc. ring; R1 = H, 1-8C alkyl, Ph or Ph-(1-8C)alkyl; R2 = 1-8C alkyl, Ph or Ph-(1-8C) alkyl; M = metal ion. (2) Pharm. compsn. for use as a Ca antagonist in the treatment of hypertension comprises a cpd. (I) but without the proviso about (B)z. (3) Pharm. compsn. for use as an antihistamine or for the redn. of gastric secretion comprises a cpd. (I) but without the proviso about (B)z.
PT84128A 1986-01-17 1987-01-16 PROCESS FOR THE PREPARATION OF N-SUBSTITUTED ARILALQUIL- AND ARYLIQUILENYAMINOHETEROCYCLIC COMPOUNDS PT84128B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81970186A 1986-01-17 1986-01-17

Publications (2)

Publication Number Publication Date
PT84128A true PT84128A (en) 1987-02-01
PT84128B PT84128B (en) 1989-05-31

Family

ID=25228814

Family Applications (1)

Application Number Title Priority Date Filing Date
PT84128A PT84128B (en) 1986-01-17 1987-01-16 PROCESS FOR THE PREPARATION OF N-SUBSTITUTED ARILALQUIL- AND ARYLIQUILENYAMINOHETEROCYCLIC COMPOUNDS

Country Status (11)

Country Link
JP (1) JPH0772171B2 (en)
KR (1) KR900005368B1 (en)
AU (1) AU594972B2 (en)
DK (1) DK347986A (en)
GR (1) GR862024B (en)
IL (1) IL78939A (en)
IN (1) IN163948B (en)
NZ (1) NZ217408A (en)
PH (3) PH23843A (en)
PT (1) PT84128B (en)
ZA (1) ZA864522B (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH23283A (en) * 1986-02-26 1989-06-30 Eisai Co Ltd Piperidine derivative, pharmaceutical composition containing the same and method of use thereof
AU629535B2 (en) * 1988-02-10 1992-10-08 A.H. Robins Company, Incorporated N-substituted-arylalkyl and arylalkylene aminoheterocyclics as cardiovascular antihistaminic and antisecretory agents
AU629534B2 (en) * 1988-02-24 1992-10-08 A.H. Robins Company, Incorporated New methods and related compounds
GB8825505D0 (en) * 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
GB8906166D0 (en) * 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
GB8928042D0 (en) * 1989-12-12 1990-02-14 Pfizer Ltd Muscarinic receptor antagonists
US6004980A (en) * 1990-06-01 1999-12-21 Merrell Pharmaceuticals, Inc. (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
CA2093798C (en) * 1990-10-10 2000-02-01 John J. Piwinski Pyridine and pyridine n-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
DE4111861A1 (en) * 1991-04-11 1992-10-15 Schwabe Willmar Gmbh & Co BENZOPYRANONE, PROCESS FOR THEIR PREPARATION AND USE
WO1993011108A1 (en) * 1991-11-29 1993-06-10 Zeria Pharmaceutical Co., Ltd. Piperidine derivative and medicine containing the same
US5807858A (en) * 1996-06-05 1998-09-15 Delta Pharmaceutical, Inc. Compositions and methods for reducing respiratory depression
US5681830A (en) * 1992-02-03 1997-10-28 Delta Pharmaceuticals, Inc. Opioid compounds
EP0635012B1 (en) * 1992-03-27 1996-07-10 Schering Corporation Unbridged bis-aryl carbinol derivatives, compositions and methods of use
HUT71132A (en) * 1992-03-27 1995-11-28 Schering Corp Bis-aryl-carbinol derivatives, pharmaceutical compositions containing them and process for producing
HU221726B1 (en) 1993-07-30 2002-12-28 Ardent Pharmaceuticals Inc. Piperazine compounds, process for producing them and pharmaceutical compositions containing them
JP4057088B2 (en) * 1996-04-22 2008-03-05 株式会社カネカ Method for producing pyrrolidine derivative
US6028083A (en) * 1997-07-25 2000-02-22 Hoechst Marion Roussel, Inc. Esters of (+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4035372A (en) * 1976-08-13 1977-07-12 G. D. Searle & Co. 4-{[4-(Diphenylmethyl)-1-piperidinyl]methyl}benzenamines
US4632925A (en) * 1985-10-07 1986-12-30 Hoffmann-La Roche Inc. N-substituted diphenylpiperidines and antiobesity use thereof
US4810713A (en) * 1985-12-20 1989-03-07 A. H. Robins Company, Incorporated Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment

Also Published As

Publication number Publication date
KR870007131A (en) 1987-08-17
NZ217408A (en) 1990-03-27
IN163948B (en) 1988-12-10
PT84128B (en) 1989-05-31
AU594972B2 (en) 1990-03-22
PH24983A (en) 1990-12-26
JPH0772171B2 (en) 1995-08-02
ZA864522B (en) 1987-02-25
DK347986D0 (en) 1986-07-22
PH24904A (en) 1990-12-26
JPS62169763A (en) 1987-07-25
PH23843A (en) 1989-11-23
DK347986A (en) 1987-07-18
AU6247386A (en) 1987-07-23
KR900005368B1 (en) 1990-07-28
IL78939A0 (en) 1986-09-30
GR862024B (en) 1986-12-24
IL78939A (en) 1990-04-29

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Legal Events

Date Code Title Description
PC3A Transfer or assignment

Free format text: 921231 A.H. ROBINS COMPANY, INCORPORATED US

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 19960531