ZA859299B - Prolonged-action immunotoxins containing a glycopeptide constituent which inactivates ribosomes,modified on its polysaccharide units - Google Patents
Prolonged-action immunotoxins containing a glycopeptide constituent which inactivates ribosomes,modified on its polysaccharide unitsInfo
- Publication number
- ZA859299B ZA859299B ZA859299A ZA859299A ZA859299B ZA 859299 B ZA859299 B ZA 859299B ZA 859299 A ZA859299 A ZA 859299A ZA 859299 A ZA859299 A ZA 859299A ZA 859299 B ZA859299 B ZA 859299B
- Authority
- ZA
- South Africa
- Prior art keywords
- prolonged
- glycopeptide
- constituent
- modified
- polysaccharide units
- Prior art date
Links
- 229940051026 immunotoxin Drugs 0.000 title abstract 2
- 230000002637 immunotoxin Effects 0.000 title abstract 2
- 239000002596 immunotoxin Substances 0.000 title abstract 2
- 231100000608 immunotoxin Toxicity 0.000 title abstract 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title 1
- 102000002068 Glycopeptides Human genes 0.000 title 1
- 108010015899 Glycopeptides Proteins 0.000 title 1
- 239000000470 constituent Substances 0.000 title 1
- 150000004676 glycans Polymers 0.000 title 1
- 150000004804 polysaccharides Polymers 0.000 title 1
- 210000003705 ribosome Anatomy 0.000 title 1
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 108090000288 Glycoproteins Proteins 0.000 abstract 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 108090000829 Ribosome Inactivating Proteins Proteins 0.000 abstract 1
- 125000000837 carbohydrate group Chemical group 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- -1 periodate ions Chemical class 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 125000000101 thioether group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8502068A FR2577135B1 (fr) | 1985-02-13 | 1985-02-13 | Immunotoxines a longue duree d'action comportant un constituant glycopeptidique inactivant les ribosomes modifie sur ses motifs polysaccharidiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA859299B true ZA859299B (en) | 1986-08-27 |
Family
ID=9316241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA859299A ZA859299B (en) | 1985-02-13 | 1985-12-04 | Prolonged-action immunotoxins containing a glycopeptide constituent which inactivates ribosomes,modified on its polysaccharide units |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0192002B1 (cs) |
| JP (1) | JPH0725701B2 (cs) |
| KR (1) | KR930003333B1 (cs) |
| AT (1) | ATE75487T1 (cs) |
| AU (1) | AU591077B2 (cs) |
| CA (1) | CA1264667A (cs) |
| DE (1) | DE3585951D1 (cs) |
| DK (1) | DK563585A (cs) |
| FR (1) | FR2577135B1 (cs) |
| GR (1) | GR852914B (cs) |
| IE (1) | IE59909B1 (cs) |
| NZ (1) | NZ214482A (cs) |
| PT (1) | PT81623B (cs) |
| ZA (1) | ZA859299B (cs) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2566271B1 (fr) * | 1984-06-20 | 1986-11-07 | Sanofi Sa | Nouveaux conjugues cytotoxiques utilisables en therapeutique et procede d'obtention |
| FR2573656B1 (fr) * | 1984-11-29 | 1987-02-27 | Sanofi Sa | Medicament comportant en tant qu'association au moins une immunotoxine et au moins un polymere contenant du mannose |
| JPH01502909A (ja) * | 1987-02-24 | 1989-10-05 | ゾーマ・コーポレーション | 免疫毒素による人間の治療における免疫抑制 |
| US4981979A (en) * | 1987-09-10 | 1991-01-01 | Neorx Corporation | Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity |
| IT1249051B (it) * | 1991-02-26 | 1995-02-11 | Italfarmaco Spa | Immunotossina da anticorpi monoclonali anti-cd5 |
| US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
| US5376546A (en) * | 1991-11-04 | 1994-12-27 | Xoma Corporation | Analogs of ribosome-inactivating proteins |
| US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| US6146850A (en) * | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47372A (en) * | 1975-05-27 | 1979-10-31 | Yeda Res & Dev | Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same |
| FR2437213A1 (fr) * | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
| JPS5616418A (en) * | 1979-07-20 | 1981-02-17 | Teijin Ltd | Antitumor protein complex and its preparation |
| EP0044167A3 (en) * | 1980-07-14 | 1982-04-21 | The Regents Of The University Of California | Antibody targeted cytotoxic agent |
| FR2504010B1 (fr) * | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| JPS5843926A (ja) * | 1981-09-08 | 1983-03-14 | Suntory Ltd | 選択性制癌剤 |
| FR2516794B1 (fr) * | 1981-11-20 | 1985-10-25 | Sanofi Sa | Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique |
| CA1203164A (en) * | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
| PT80662B (en) * | 1984-06-20 | 1986-12-09 | Sanofi Sa | Process to obtain anti-tumoral glycoprotein modified on its glycidic portions |
-
1985
- 1985-02-13 FR FR8502068A patent/FR2577135B1/fr not_active Expired
- 1985-12-04 GR GR852914A patent/GR852914B/el unknown
- 1985-12-04 ZA ZA859299A patent/ZA859299B/xx unknown
- 1985-12-04 DE DE8585402403T patent/DE3585951D1/de not_active Expired - Fee Related
- 1985-12-04 AT AT85402403T patent/ATE75487T1/de active
- 1985-12-04 EP EP85402403A patent/EP0192002B1/fr not_active Expired - Lifetime
- 1985-12-05 CA CA000497004A patent/CA1264667A/en not_active Expired - Fee Related
- 1985-12-05 AU AU50783/85A patent/AU591077B2/en not_active Ceased
- 1985-12-05 IE IE307185A patent/IE59909B1/en not_active IP Right Cessation
- 1985-12-05 DK DK563585A patent/DK563585A/da not_active Application Discontinuation
- 1985-12-05 KR KR1019850009153A patent/KR930003333B1/ko not_active Expired - Fee Related
- 1985-12-05 PT PT81623A patent/PT81623B/pt not_active IP Right Cessation
- 1985-12-06 JP JP60274840A patent/JPH0725701B2/ja not_active Expired - Lifetime
- 1985-12-09 NZ NZ214482A patent/NZ214482A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE853071L (en) | 1986-08-13 |
| NZ214482A (en) | 1989-08-29 |
| PT81623B (pt) | 1988-04-21 |
| GR852914B (cs) | 1986-04-07 |
| DE3585951D1 (de) | 1992-06-04 |
| FR2577135A1 (fr) | 1986-08-14 |
| PT81623A (fr) | 1986-01-01 |
| AU591077B2 (en) | 1989-11-30 |
| CA1264667A (en) | 1990-01-23 |
| AU5078385A (en) | 1986-08-14 |
| DK563585A (da) | 1986-08-14 |
| EP0192002A1 (fr) | 1986-08-27 |
| ATE75487T1 (de) | 1992-05-15 |
| KR930003333B1 (ko) | 1993-04-26 |
| JPS61200925A (ja) | 1986-09-05 |
| IE59909B1 (en) | 1994-04-20 |
| DK563585D0 (da) | 1985-12-05 |
| JPH0725701B2 (ja) | 1995-03-22 |
| KR860006482A (ko) | 1986-09-11 |
| EP0192002B1 (fr) | 1992-04-29 |
| FR2577135B1 (fr) | 1989-12-15 |
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