GR852914B - - Google Patents
Info
- Publication number
- GR852914B GR852914B GR852914A GR850102914A GR852914B GR 852914 B GR852914 B GR 852914B GR 852914 A GR852914 A GR 852914A GR 850102914 A GR850102914 A GR 850102914A GR 852914 B GR852914 B GR 852914B
- Authority
- GR
- Greece
- Prior art keywords
- prolonged
- antibody
- group
- ribosome
- conjugate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8502068A FR2577135B1 (fr) | 1985-02-13 | 1985-02-13 | Immunotoxines a longue duree d'action comportant un constituant glycopeptidique inactivant les ribosomes modifie sur ses motifs polysaccharidiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR852914B true GR852914B (el) | 1986-04-07 |
Family
ID=9316241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR852914A GR852914B (el) | 1985-02-13 | 1985-12-04 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0192002B1 (el) |
| JP (1) | JPH0725701B2 (el) |
| KR (1) | KR930003333B1 (el) |
| AT (1) | ATE75487T1 (el) |
| AU (1) | AU591077B2 (el) |
| CA (1) | CA1264667A (el) |
| DE (1) | DE3585951D1 (el) |
| DK (1) | DK563585A (el) |
| FR (1) | FR2577135B1 (el) |
| GR (1) | GR852914B (el) |
| IE (1) | IE59909B1 (el) |
| NZ (1) | NZ214482A (el) |
| PT (1) | PT81623B (el) |
| ZA (1) | ZA859299B (el) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2566271B1 (fr) * | 1984-06-20 | 1986-11-07 | Sanofi Sa | Nouveaux conjugues cytotoxiques utilisables en therapeutique et procede d'obtention |
| FR2573656B1 (fr) * | 1984-11-29 | 1987-02-27 | Sanofi Sa | Medicament comportant en tant qu'association au moins une immunotoxine et au moins un polymere contenant du mannose |
| EP0303681B1 (en) * | 1987-02-24 | 1992-10-14 | Xoma Corporation | Immunosuppression in immunotoxin based human therapy |
| US4981979A (en) * | 1987-09-10 | 1991-01-01 | Neorx Corporation | Immunoconjugates joined by thioether bonds having reduced toxicity and improved selectivity |
| IT1249051B (it) * | 1991-02-26 | 1995-02-11 | Italfarmaco Spa | Immunotossina da anticorpi monoclonali anti-cd5 |
| US6146850A (en) | 1991-11-04 | 2000-11-14 | Xoma Corporation | Proteins encoding gelonin sequences |
| US5621083A (en) * | 1991-11-04 | 1997-04-15 | Xoma Corporation | Immunotoxins comprising ribosome-inactivating proteins |
| US5376546A (en) * | 1991-11-04 | 1994-12-27 | Xoma Corporation | Analogs of ribosome-inactivating proteins |
| US5837491A (en) * | 1991-11-04 | 1998-11-17 | Xoma Corporation | Polynucleotides encoding gelonin sequences |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL47372A (en) * | 1975-05-27 | 1979-10-31 | Yeda Res & Dev | Fab'dimers bound to daunomycin or adriamycin,their preparation and pharmaceutical compositions containing same |
| FR2437213A1 (fr) * | 1978-09-28 | 1980-04-25 | Cm Ind | Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation |
| JPS5616418A (en) * | 1979-07-20 | 1981-02-17 | Teijin Ltd | Antitumor protein complex and its preparation |
| EP0044167A3 (en) * | 1980-07-14 | 1982-04-21 | The Regents Of The University Of California | Antibody targeted cytotoxic agent |
| FR2504010B1 (fr) * | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| JPS5843926A (ja) * | 1981-09-08 | 1983-03-14 | Suntory Ltd | 選択性制癌剤 |
| FR2516794B1 (fr) * | 1981-11-20 | 1985-10-25 | Sanofi Sa | Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique |
| CA1203164A (en) * | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
| PT80662B (en) * | 1984-06-20 | 1986-12-09 | Sanofi Sa | Process to obtain anti-tumoral glycoprotein modified on its glycidic portions |
-
1985
- 1985-02-13 FR FR8502068A patent/FR2577135B1/fr not_active Expired
- 1985-12-04 DE DE8585402403T patent/DE3585951D1/de not_active Expired - Fee Related
- 1985-12-04 AT AT85402403T patent/ATE75487T1/de active
- 1985-12-04 EP EP85402403A patent/EP0192002B1/fr not_active Expired - Lifetime
- 1985-12-04 GR GR852914A patent/GR852914B/el unknown
- 1985-12-04 ZA ZA859299A patent/ZA859299B/xx unknown
- 1985-12-05 IE IE307185A patent/IE59909B1/en not_active IP Right Cessation
- 1985-12-05 PT PT81623A patent/PT81623B/pt not_active IP Right Cessation
- 1985-12-05 DK DK563585A patent/DK563585A/da not_active Application Discontinuation
- 1985-12-05 CA CA000497004A patent/CA1264667A/en not_active Expired - Fee Related
- 1985-12-05 KR KR1019850009153A patent/KR930003333B1/ko not_active IP Right Cessation
- 1985-12-05 AU AU50783/85A patent/AU591077B2/en not_active Ceased
- 1985-12-06 JP JP60274840A patent/JPH0725701B2/ja not_active Expired - Lifetime
- 1985-12-09 NZ NZ214482A patent/NZ214482A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT81623A (fr) | 1986-01-01 |
| AU5078385A (en) | 1986-08-14 |
| KR930003333B1 (ko) | 1993-04-26 |
| PT81623B (pt) | 1988-04-21 |
| KR860006482A (ko) | 1986-09-11 |
| CA1264667A (en) | 1990-01-23 |
| ATE75487T1 (de) | 1992-05-15 |
| DK563585D0 (da) | 1985-12-05 |
| NZ214482A (en) | 1989-08-29 |
| EP0192002A1 (fr) | 1986-08-27 |
| FR2577135A1 (fr) | 1986-08-14 |
| EP0192002B1 (fr) | 1992-04-29 |
| AU591077B2 (en) | 1989-11-30 |
| IE853071L (en) | 1986-08-13 |
| DK563585A (da) | 1986-08-14 |
| IE59909B1 (en) | 1994-04-20 |
| JPS61200925A (ja) | 1986-09-05 |
| DE3585951D1 (de) | 1992-06-04 |
| ZA859299B (en) | 1986-08-27 |
| FR2577135B1 (fr) | 1989-12-15 |
| JPH0725701B2 (ja) | 1995-03-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0272681A3 (en) | Lighting system | |
| ES8605105A1 (es) | Un conjugado de una molecula biologicamente activa | |
| SE8306327L (sv) | Ortodontisk brackett | |
| IE853071L (en) | Immunotoxin | |
| GR78934B (el) | ||
| IL71366A (en) | Immunoglobulin conjugates with vincaleukoblastine derivatives,their production and pharmaceutical compositions containing them | |
| ES2043609T3 (es) | Composiciones de interleucina-2. | |
| AU549495B2 (en) | Immunoglobulin-vindesine conjugates | |
| FR2509255B1 (el) | ||
| ES2028277T3 (es) | Sintesis de zeolita l. | |
| PH23901A (en) | Treatment of diabetes using fluoxetine | |
| IE890607L (en) | Antihypertensive hyperimmune milk, production, composition, and use | |
| NZ221065A (en) | Conjugates of antibodies and toxins with sulphur-containing linking groups | |
| GR3004189T3 (el) | ||
| EP0601318A3 (de) | Verfahren zur Herstellung von Konjugaten aus einem spezifischen Bindungspartner und einem kohlenhydrathaltigen Protein. | |
| GR3007486T3 (el) | ||
| ES2031655T3 (es) | Elemento modular de techado. | |
| ES2024632B3 (es) | Caseta de separacion. | |
| ES253149U (es) | Conjunto encendedor-abrebotellas | |
| ES1000783U (es) | Juguete tentetieso | |
| EP0238765A3 (en) | 2,2-diphenoxy-n,n-dimethylaminoethane for improving cerebral oxygenation | |
| ES259512U (es) | Elefante artificial expendedor de bebidas |