ZA858659B - Use of spergualin derivatives for the preparation of medicaments having immunosuppressive activity - Google Patents

Use of spergualin derivatives for the preparation of medicaments having immunosuppressive activity

Info

Publication number
ZA858659B
ZA858659B ZA858659A ZA858659A ZA858659B ZA 858659 B ZA858659 B ZA 858659B ZA 858659 A ZA858659 A ZA 858659A ZA 858659 A ZA858659 A ZA 858659A ZA 858659 B ZA858659 B ZA 858659B
Authority
ZA
South Africa
Prior art keywords
medicaments
preparation
immunosuppressive activity
spergualin
derivatives
Prior art date
Application number
ZA858659A
Other languages
English (en)
Inventor
Hamao Umezawa
Tomio Takeuchi
Masaaki Ishizuka
Fuminori Abe
Akio Fuji
Teruya Nakamura
Original Assignee
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found
Publication of ZA858659B publication Critical patent/ZA858659B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA858659A 1984-11-13 1985-11-12 Use of spergualin derivatives for the preparation of medicaments having immunosuppressive activity ZA858659B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59237480A JPS61129119A (ja) 1984-11-13 1984-11-13 新規免疫抑制剤

Publications (1)

Publication Number Publication Date
ZA858659B true ZA858659B (en) 1986-07-30

Family

ID=17015948

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA858659A ZA858659B (en) 1984-11-13 1985-11-12 Use of spergualin derivatives for the preparation of medicaments having immunosuppressive activity

Country Status (7)

Country Link
EP (1) EP0181592B1 (fr)
JP (1) JPS61129119A (fr)
AT (1) ATE80613T1 (fr)
DE (1) DE3586649T2 (fr)
DK (1) DK173952B1 (fr)
IE (1) IE59251B1 (fr)
ZA (1) ZA858659B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61134312A (ja) * 1984-12-06 1986-06-21 Microbial Chem Res Found 移植免疫抑制剤並びに抗アレルギ−剤
JPH0742268B2 (ja) * 1985-08-27 1995-05-10 財団法人微生物化学研究会 フエニレン基を有するスパガリン類縁化合物及びその製造法
DE3626306A1 (de) * 1986-08-02 1988-02-11 Behringwerke Ag Verwendung von 15-deoxyspergualin als arzneimittel
JPH0794424B2 (ja) * 1987-09-30 1995-10-11 財団法人微生物化学研究会 新スパガリン関連化合物およびその製造法
US4990536A (en) * 1989-04-03 1991-02-05 Nippon Kayaku Kabushiki Kaisha Immunopotentiator and spergualin-related compound therefor
WO1994004140A1 (fr) * 1992-08-19 1994-03-03 Nippon Kayaku Kabushiki Kaisha Medicament anti-protozoose
FR2716452B1 (fr) * 1994-02-24 1996-05-10 Fournier Ind & Sante Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR2716451B1 (fr) * 1994-02-24 1996-04-26 Fournier Ind & Sante Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en thérapeutique.
FR2730488B1 (fr) * 1995-02-10 1997-04-30 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur utilisation en therapeutique et leur procede de preparation
FR2737891B1 (fr) * 1995-08-17 1997-10-24 Fournier Ind & Sante Analogues chiraux de la 15-deoxyspergualine, procede de preparation et utilisation en therapeutique
CA2187281A1 (fr) * 1995-02-10 1996-08-15 Luc Lebreton Analogues de la 15-deoxyspergualine, leur utilisation en therapeutique et leur procede de preparation
FR2734263B1 (fr) * 1995-05-17 1997-06-20 Fournier Ind & Sante Analogues de la 15-deoxyspergualine, leur procede de preparation et leur utilisation en therapeutique

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5285179A (en) * 1976-01-08 1977-07-15 Mitsui Toatsu Chem Inc Preparation of carbamoylated 5-fluorouracils
JPS5368730A (en) * 1976-12-01 1978-06-19 Yoshitomi Pharmaceut Ind Ltd Penicillamin derivatives
JPS5419997A (en) * 1977-07-15 1979-02-15 Intorepurinderea De Anteibiote 33formylrifamycin sv derivative
JPS567753A (en) * 1979-07-02 1981-01-27 Takeda Chem Ind Ltd Preparation of aromatic sulfinic acid
JPS5862152A (ja) * 1981-10-08 1983-04-13 Microbial Chem Res Found Ｎ−〔４−（３−アミノプロピル）アミノブチル〕−２−（ω−グアニジノ脂肪酸アミド）−２−ヒドロキシエタンアミドおよびその誘導体ならびにその製造法
JPS58198455A (ja) * 1982-05-17 1983-11-18 Microbial Chem Res Found （−）−１５−デオキシスパガリンおよびその製造法並びにその中間体
JPS5942356A (ja) * 1982-09-02 1984-03-08 Microbial Chem Res Found スパガリン関連化合物およびその製造法
JPS5976046A (ja) * 1982-10-25 1984-04-28 Microbial Chem Res Found スパガリン−１１−ｏ−アルキル誘導体およびその関連化合物並びにそれらの製造法
DE3305755A1 (de) * 1983-02-19 1984-08-23 Gödecke AG, 1000 Berlin N-phenyl-benzamid-derivate, verfahren zu deren herstellung und deren verwendung bei der bekaempfung von erkranungen des immunsystems
JPS60181056A (ja) * 1984-02-29 1985-09-14 Takara Shuzo Co Ltd Ν−〔４−（３−アミノプロピル）アミノブチル〕−２，２−ジヒドロキシエタンアミドの製造法
JPS60185758A (ja) * 1984-03-02 1985-09-21 Microbial Chem Res Found フエニレン基を有するスパガリン関連化合物およびその製造法
JPS61165322A (ja) * 1985-01-14 1986-07-26 Microbial Chem Res Found スパガリン類の注射用凍結乾燥製剤
JPH0742268B2 (ja) * 1985-08-27 1995-05-10 財団法人微生物化学研究会 フエニレン基を有するスパガリン類縁化合物及びその製造法

Also Published As

Publication number Publication date
JPS61129119A (ja) 1986-06-17
DE3586649T2 (de) 1993-03-11
DE3586649D1 (de) 1992-10-22
JPH0414643B2 (fr) 1992-03-13
IE59251B1 (en) 1994-01-26
ATE80613T1 (de) 1992-10-15
EP0181592A3 (en) 1990-08-29
DK521685D0 (da) 1985-11-12
EP0181592A2 (fr) 1986-05-21
IE852823L (en) 1986-05-13
EP0181592B1 (fr) 1992-09-16
DK173952B1 (da) 2002-03-04
DK521685A (da) 1986-05-14

Similar Documents

Publication Publication Date Title
NZ214610A (en) Piperazine derivatives and pharmaceutical compositions
HUT59109A (en) Process for producing hydroxymethyl-(methylenecyclopentyl)-purines and -pyrimidines, their pharmaceutically acceptable salts and pharmaceutical compositions comprising same
IL86381A0 (en) Oxetanocins and pharmaceutical compositions containing the same
EP0326307A3 (en) Novel pyridazinone derivatives and pharmaceutical preparations containing them
NZ214156A (en) Quindone derivatives and pharmaceutical compositions
EP0181592A3 (en) Use of spergualin derivatives for the preparation of medicaments having immunosuppressive activity
NZ210100A (en) 5h,11h-pyrrolo(2,1-c)(1,4)benzoxazepine derivatives and pharmaceutical compositons
ES8601915A1 (es) Un procedimiento para preparar derivados de piridazinona
IL86080A0 (en) Bicyclic compounds,processes for preparation thereof and pharmaceutical composition comprising the same
DE69001722D1 (de) Entzuendungshemmende und/oder antiallergische zusammensetzung, die glutathionderivate enthaelt.
NO910904D0 (no) Fremgangsmaate for fremstilling av en substituert aminforbindelse.
EP0175266A3 (en) Antihypertensive derivatives
PT76693A (en) (-)-15-deoxyspergualin a process for the preparation of the same an intermediate of the same and its use as medicament
DK0855398T3 (da) Sesquiterpenderivater med antiviral aktivitet
GR3007498T3 (fr)
ES8604210A1 (es) Procedimiento para preparar 2- (fenetil) -5- (3,4-metilen- dioxi)-x-hidroxibencil) -pirrolidina
EP0177728A3 (en) Arphamenine derivatives, a process for their preparation and their use as medicament