ZA854072B - New substituted pyrrolidinones,processes for preparing them and pharmaceutical compositions - Google Patents

New substituted pyrrolidinones,processes for preparing them and pharmaceutical compositions

Info

Publication number
ZA854072B
ZA854072B ZA854072A ZA854072A ZA854072B ZA 854072 B ZA854072 B ZA 854072B ZA 854072 A ZA854072 A ZA 854072A ZA 854072 A ZA854072 A ZA 854072A ZA 854072 B ZA854072 B ZA 854072B
Authority
ZA
South Africa
Prior art keywords
group
carbon atoms
alkyl group
substituted
chained
Prior art date
Application number
ZA854072A
Other languages
English (en)
Inventor
Karl Heinz Weber
Claus Schneider
Gerhard Walther
Dieter Hinzen
Franz J Kuhn
Erich Lehr
Helmut Einsinger
Wolfgang Troeger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ZA854072B publication Critical patent/ZA854072B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA854072A 1984-05-30 1985-05-29 New substituted pyrrolidinones,processes for preparing them and pharmaceutical compositions ZA854072B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843420193 DE3420193A1 (de) 1984-05-30 1984-05-30 Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel

Publications (1)

Publication Number Publication Date
ZA854072B true ZA854072B (en) 1987-02-25

Family

ID=6237240

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA854072A ZA854072B (en) 1984-05-30 1985-05-29 New substituted pyrrolidinones,processes for preparing them and pharmaceutical compositions

Country Status (22)

Country Link
US (4) US4670456A (cs)
EP (1) EP0163260B1 (cs)
JP (1) JPS6168A (cs)
KR (1) KR850008343A (cs)
AT (1) ATE36151T1 (cs)
AU (1) AU581438B2 (cs)
CA (1) CA1255664A (cs)
CS (1) CS261883B2 (cs)
DD (1) DD235256A5 (cs)
DE (2) DE3420193A1 (cs)
DK (1) DK239685A (cs)
ES (4) ES8607926A1 (cs)
FI (1) FI78462C (cs)
GR (1) GR851306B (cs)
HU (1) HU193393B (cs)
IL (1) IL75339A (cs)
NO (1) NO852133L (cs)
NZ (1) NZ212241A (cs)
PL (1) PL144921B1 (cs)
PT (1) PT80545B (cs)
SU (1) SU1360583A3 (cs)
ZA (1) ZA854072B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
FR2597100A1 (fr) * 1986-01-21 1987-10-16 Nippon Shinyaku Co Ltd Derives du pyroglutamide
US4960776A (en) * 1987-01-28 1990-10-02 A. H. Robins Company, Inc. 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicamino)alkyl)-1-piperazinecarboxamides
CA1305148C (en) * 1987-08-19 1992-07-14 Hiromu Matsumura Carbamoylpyrrolidone derivatives and drugs for senile dementia
US4833139A (en) * 1988-01-25 1989-05-23 Hoechst-Roussel Pharmaceuticals, Inc. Enhancing cholinergic activity with 5-substituted 1-[4-(1-pyrrolidinyl)-2-butynyl]-2-pyrrolidinones and related compounds
EP0342613B1 (en) * 1988-05-20 1992-11-11 ZAMBON GROUP S.p.A. Compounds with central analgesic activity, process for their preparation and pharmaceutical compositions containing them
JPH02137427A (ja) * 1988-11-18 1990-05-25 Du Pont Opt Electron Kk 光電気的接続装置及び光コンセント
US4981974A (en) * 1989-05-08 1991-01-01 Gaf Chemicals Corporation Polymerizable pyrrolidonyl oxazoline monomers
TW448172B (en) * 1996-03-08 2001-08-01 Pharmacia & Upjohn Co Llc Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
TWI294778B (en) * 2002-03-13 2008-03-21 Smithkline Beecham Corp Peptide deformylase inhibitors
BRPI0708887A2 (pt) * 2006-03-13 2011-06-14 Activx Biosciences Inc composto ou um derivado farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, mÉtodos para inibir uma aÇço de gsk-3, e para tratar, prevenir ou melhorar uma doenÇa, artigo de fabricaÇço, e, uso de um composto
WO2009035634A2 (en) * 2007-09-11 2009-03-19 Activx Biosciences, Inc. Cyanoaminoquinolones and tetrazoloaminoquinolones as gsk-3 inhibitors
WO2009071668A2 (en) 2007-12-05 2009-06-11 Biovitrum Ab (Publ) Piperazine derivatives and their use as leptin receptor modulators
CN102026975A (zh) * 2007-12-05 2011-04-20 阿斯利康(瑞典)有限公司 作为抗肥胖药的哌嗪衍生物
CA2726646A1 (en) * 2008-06-04 2009-12-10 Astrazeneca Ab New compounds vii
KR101748891B1 (ko) * 2009-03-11 2017-06-19 교린 세이야꾸 가부시키 가이샤 Ｇｓｋ-3 억제제로서의 7-시클로알킬아미노퀴놀론

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838914A (en) * 1957-07-03 1958-06-17 Olin Mathieson Isonicotinic acid hydrazide derivatives
GB1039113A (en) * 1964-08-06 1966-08-17 Ucb Sa New n-substituted lactams
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
JPS4924916B1 (cs) * 1970-08-14 1974-06-26
FR2387218A1 (fr) * 1977-04-15 1978-11-10 Ile De France Nouveaux n-(1'-ethyl 2'-oxo 5'-pyrrolidinyl methyl) benzamides, leurs procedes de preparation et leur application comme modificateurs du comportement
CU21107A3 (es) * 1978-02-10 1988-02-01 Hoffmann La Roche Pyrrolidines derivatives
DE3326724A1 (de) * 1983-07-25 1985-02-07 Boehringer Ingelheim KG, 6507 Ingelheim In 1-stellung substituierte 4-hydroxymethyl-pyrrolidinone, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen und zwischenprodukte
DE3336024A1 (de) * 1983-10-04 1985-04-18 Boehringer Ingelheim KG, 6507 Ingelheim 4-amino-l-benzyl-pyrrolidinone und ihre saeureadditionssalze, verfahren zu ihrer herstellung und arzneimittel
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
US4670436A (en) * 1986-08-29 1987-06-02 Mcneilab, Inc. Hypoglycemic 5-substituted pyrrolidinylidene compounds, compositions and use

Also Published As

Publication number Publication date
AU581438B2 (en) 1989-02-23
JPS6168A (ja) 1986-01-06
EP0163260B1 (de) 1988-08-03
US4857528A (en) 1989-08-15
ES552410A0 (es) 1987-09-01
US4670456A (en) 1987-06-02
ES8707928A1 (es) 1987-09-01
PL253668A1 (en) 1986-05-20
SU1360583A3 (ru) 1987-12-15
DE3564105D1 (en) 1988-09-08
US4762832A (en) 1988-08-09
DD235256A5 (de) 1986-04-30
ES8707927A1 (es) 1987-09-01
ES8607926A1 (es) 1986-06-01
FI78462C (fi) 1989-08-10
KR850008343A (ko) 1985-12-16
EP0163260A1 (de) 1985-12-04
PL144921B1 (en) 1988-07-30
NO852133L (no) 1985-12-02
GR851306B (cs) 1985-11-25
CS261883B2 (en) 1989-02-10
DE3420193A1 (de) 1985-12-05
FI852130L (fi) 1985-12-01
AU4317085A (en) 1985-12-05
PT80545A (de) 1985-06-01
FI852130A0 (fi) 1985-05-29
ES552409A0 (es) 1987-12-16
IL75339A (en) 1988-07-31
ATE36151T1 (de) 1988-08-15
US4891378A (en) 1990-01-02
HUT37751A (en) 1986-02-28
NZ212241A (en) 1989-07-27
IL75339A0 (en) 1985-09-29
FI78462B (fi) 1989-04-28
ES552411A0 (es) 1987-09-01
ES8801200A1 (es) 1987-12-16
PT80545B (de) 1987-04-06
ES543592A0 (es) 1986-06-01
DK239685A (da) 1985-12-01
HU193393B (en) 1987-09-28
CS385485A2 (en) 1988-06-15
CA1255664A (en) 1989-06-13
JPH0517904B2 (cs) 1993-03-10
DK239685D0 (da) 1985-05-29

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