ZA852971B - New process for the synthesis of pyrido-imidazo rifamycins - Google Patents

New process for the synthesis of pyrido-imidazo rifamycins

Info

Publication number
ZA852971B
ZA852971B ZA852971A ZA852971A ZA852971B ZA 852971 B ZA852971 B ZA 852971B ZA 852971 A ZA852971 A ZA 852971A ZA 852971 A ZA852971 A ZA 852971A ZA 852971 B ZA852971 B ZA 852971B
Authority
ZA
South Africa
Prior art keywords
pyrido
synthesis
new process
rifamycins
imidazo
Prior art date
Application number
ZA852971A
Other languages
English (en)
Inventor
Vincenzo Cannata
Gian Franco Tamagnone
Silvano Piani
Egidio Marchi
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of ZA852971B publication Critical patent/ZA852971B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA852971A 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo rifamycins ZA852971B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03463/84A IT1199374B (it) 1984-05-15 1984-05-15 Processo per la preparazione di pirido-imidazo-rifamicine

Publications (1)

Publication Number Publication Date
ZA852971B true ZA852971B (en) 1985-12-24

Family

ID=11107845

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA852971A ZA852971B (en) 1984-05-15 1985-04-19 New process for the synthesis of pyrido-imidazo rifamycins

Country Status (18)

Country Link
US (1) US4557866A (show.php)
EP (1) EP0161534B1 (show.php)
JP (1) JPS60252483A (show.php)
AR (1) AR241913A1 (show.php)
AT (1) ATE46512T1 (show.php)
AU (1) AU568934B2 (show.php)
CA (1) CA1215708A (show.php)
DE (1) DE3573120D1 (show.php)
DK (1) DK162647C (show.php)
ES (1) ES8603489A1 (show.php)
FI (1) FI81101C (show.php)
GR (1) GR851144B (show.php)
IE (1) IE58392B1 (show.php)
IT (1) IT1199374B (show.php)
NO (1) NO164242C (show.php)
PH (1) PH22007A (show.php)
PT (1) PT80446B (show.php)
ZA (1) ZA852971B (show.php)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7078399B2 (en) * 2001-12-13 2006-07-18 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
US7923553B2 (en) 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7906542B2 (en) 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
ITMI20032144A1 (it) 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US7902206B2 (en) 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
SI1698630T1 (sl) * 2005-03-03 2015-01-30 Alfa Wassermann S.P.A. Nove polimorfne oblike rifaksimina, postopki za njihovo pripravo in njihova uporaba v medicinskih pripravkih
ITBO20050123A1 (it) * 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
EP1996710B1 (en) 2006-03-09 2019-08-14 Salix Pharmaceuticals, Inc. Rifaximin anti-rectal dysfunction preparation
ES2538478T3 (es) 2006-08-02 2015-06-22 Salix Pharmaceuticals, Inc. Métodos para el tratamiento de enteritis por radiación
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
AU2007298733B2 (en) * 2006-09-22 2012-11-08 Cipla Limited Rifaximin
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
US7709634B2 (en) 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
JP5706693B2 (ja) * 2008-02-25 2015-04-22 サリックス ファーマシューティカルズ リミテッド リファキシミンの型およびその使用
US8486956B2 (en) 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
DK2252148T3 (da) 2008-02-26 2019-05-06 Salix Pharmaceuticals Ltd Fremgangsmåder til behandling af irritabel tarmsyndrom
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
PL2294012T3 (pl) 2008-05-07 2014-12-31 Salix Pharmaceuticals Inc Podawanie środka czyszczącego jelito i antybiotyku w leczeniu choroby jelit
CN101585843B (zh) * 2008-05-21 2011-07-06 重庆赛诺生物药业股份有限公司 一种利福昔明的制备工艺
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
US20110035232A1 (en) 2008-10-02 2011-02-10 Salix Pharmaceuticals, Ltd. Methods of treating hepatic encephalopathy
CN102245615A (zh) 2008-10-02 2011-11-16 萨利克斯药品有限公司 治疗肝性脑病的方法
EP2355805B1 (en) 2008-12-10 2019-02-13 Cipla Limited Rifaximin complexes
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
KR20170036116A (ko) 2009-06-02 2017-03-31 샐릭스 파마슈티컬스 리미티드 간성 뇌병증의 치료방법
NZ598671A (en) 2009-09-13 2014-02-28 Salix Pharmaceuticals Ltd Methods for treating irritable bowel syndrome (ibs)
WO2011061519A2 (en) 2009-11-23 2011-05-26 Cipla Limited Topical foam composition
WO2011080691A1 (en) 2009-12-28 2011-07-07 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
EP2536282A4 (en) 2010-02-18 2013-07-03 Salix Pharmaceuticals Ltd METHOD FOR THE TREATMENT OF INFECTIONS
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
WO2011156897A2 (en) * 2010-06-16 2011-12-22 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
JP5943915B2 (ja) 2010-07-12 2016-07-05 サリックス ファーマスーティカルズ，リミテッド リファキシミンの製剤およびその使用
WO2012035544A2 (en) 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
EA201391171A1 (ru) 2011-02-11 2014-11-28 Сэликс Фармасьютиклз, Лтд. Формы рифаксимина и их применение
CA2834829A1 (en) 2011-05-02 2012-11-08 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
WO2012155981A1 (en) 2011-05-19 2012-11-22 Friulchem Spa New process for the synthesis of rifaximin and a new pseudo-crystalline form of rifaximin obtained thereby
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
JP2014532723A (ja) 2011-11-02 2014-12-08 サリックス ファーマスーティカルズ，リミテッド 過敏性腸症候群（ｉｂｓ）及び感染症を治療するための方法
US9359374B2 (en) 2012-06-13 2016-06-07 Apotex Pharmachem Inc. Polymorphic forms of rifaximin
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
EP2971062A2 (en) 2013-03-15 2016-01-20 ALFA WASSERMANN S.p.A. Method for diagnosing vaginal infections
AU2014229467A1 (en) 2013-03-15 2015-08-06 Alfa Wassermann S.P.A. Rifaximin for use in the treating of vaginal infections.
CA2908525C (en) 2013-04-12 2021-04-06 Alfa Wassermann S.P.A. Nsaid administration and related compositions, methods and systems
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ITMI20131307A1 (it) 2013-08-02 2015-02-02 A M S A Anonima Materie Sint & Affini S P A Processo per la preparazione di refaximina k
CN103509038B (zh) * 2013-09-30 2016-01-20 浙江思贤制药有限公司 一种新晶型利福昔明ζ及其制备方法
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
CN106795192B (zh) 2014-05-04 2020-06-16 萨利克斯药品公司 Ibs微生物群及其用途
EP3143027B1 (en) 2014-05-12 2019-07-10 Alfasigma S.p.A. New solvated crystal form of rifaximin, production, compositions and uses thereof
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
CA3038312A1 (en) 2016-09-30 2018-04-05 Salix Pharmaceuticals, Inc. Solid dispersion forms of rifaximin
WO2019003076A1 (en) * 2017-06-26 2019-01-03 Biofer S.P.A. PYRIDO-IMIDAZO-RIFAMYCIN DERIVATIVES AS ANTIBACTERIAL AGENT

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1154655B (it) 1980-05-22 1987-01-21 Alfa Farmaceutici Spa Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Also Published As

Publication number Publication date
US4557866A (en) 1985-12-10
PT80446B (pt) 1987-11-11
AU568934B2 (en) 1988-01-14
IT8403463A0 (it) 1984-05-15
NO851921L (no) 1985-11-18
ES543115A0 (es) 1986-01-01
DK214685D0 (da) 1985-05-14
JPS60252483A (ja) 1985-12-13
IE851191L (en) 1985-11-15
DE3573120D1 (en) 1989-10-26
NO164242B (no) 1990-06-05
FI851907A0 (fi) 1985-05-14
JPH0469634B2 (show.php) 1992-11-06
EP0161534A3 (en) 1987-03-04
DK162647C (da) 1992-04-13
AR241913A1 (es) 1993-01-29
FI851907L (fi) 1985-11-16
EP0161534B1 (en) 1989-09-20
PH22007A (en) 1988-05-02
DK214685A (da) 1985-11-16
ES8603489A1 (es) 1986-01-01
DK162647B (da) 1991-11-25
AU4251585A (en) 1985-11-21
PT80446A (en) 1985-06-01
NO164242C (no) 1990-09-12
EP0161534A2 (en) 1985-11-21
GR851144B (show.php) 1985-11-25
FI81101B (fi) 1990-05-31
IE58392B1 (en) 1993-09-08
ATE46512T1 (de) 1989-10-15
CA1215708A (en) 1986-12-23
IT1199374B (it) 1988-12-30
FI81101C (fi) 1990-09-10

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