ZA811069B - New 1-((2-mercatocycloalkyl) carbonyl)-l-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents - Google Patents
New 1-((2-mercatocycloalkyl) carbonyl)-l-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agentsInfo
- Publication number
- ZA811069B ZA811069B ZA00811069A ZA811069A ZA811069B ZA 811069 B ZA811069 B ZA 811069B ZA 00811069 A ZA00811069 A ZA 00811069A ZA 811069 A ZA811069 A ZA 811069A ZA 811069 B ZA811069 B ZA 811069B
- Authority
- ZA
- South Africa
- Prior art keywords
- mercatocycloalkyl
- intermediates
- carbonyl
- synthesis
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/20—Unsaturated compounds having a carboxyl group bound to a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8007756 | 1980-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA811069B true ZA811069B (en) | 1982-03-31 |
Family
ID=10511933
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA00811069A ZA811069B (en) | 1980-03-07 | 1981-02-18 | New 1-((2-mercatocycloalkyl) carbonyl)-l-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents |
Country Status (26)
Country | Link |
---|---|
US (1) | US4496743A (xx) |
JP (1) | JPS56139456A (xx) |
AR (1) | AR231126A1 (xx) |
AT (1) | AT375641B (xx) |
AU (1) | AU542211B2 (xx) |
BE (1) | BE887825A (xx) |
CA (1) | CA1144172A (xx) |
CH (1) | CH649531A5 (xx) |
DE (1) | DE3108543A1 (xx) |
DK (1) | DK102381A (xx) |
ES (2) | ES8201969A1 (xx) |
FI (1) | FI810615L (xx) |
FR (1) | FR2477539A1 (xx) |
GR (1) | GR74121B (xx) |
IE (1) | IE50989B1 (xx) |
IL (1) | IL62194A (xx) |
IT (1) | IT1169217B (xx) |
LU (1) | LU83186A1 (xx) |
MA (1) | MA19086A1 (xx) |
NL (1) | NL8101086A (xx) |
NO (1) | NO155007C (xx) |
PH (1) | PH15896A (xx) |
PT (1) | PT72633B (xx) |
SE (1) | SE447104B (xx) |
YU (1) | YU58781A (xx) |
ZA (1) | ZA811069B (xx) |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
FR2394529A2 (fr) * | 1977-06-13 | 1979-01-12 | Synthelabo | Methoxy-2 benzamides et leur application en therapeutique |
US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
US4091024A (en) * | 1976-12-03 | 1978-05-23 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
US4123544A (en) * | 1977-03-02 | 1978-10-31 | Merrell Toraude S. A. | Acetylsalicylic acid derivatives |
US4108886A (en) * | 1977-03-11 | 1978-08-22 | E. R. Squibb & Sons, Inc. | Thiopropanoylamino acid derivatives |
PH15381A (en) * | 1978-02-21 | 1982-12-17 | Squibb & Sons Inc | Halogen substituted mercaptoacylamino acids |
JPS54138551A (en) * | 1978-04-14 | 1979-10-27 | Sumitomo Chem Co Ltd | Novel asymmetric synthesis of optically active 2-alkanoyl- 1,2,3,4-tetrahydro-2-naphthol compound |
CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
US4297282A (en) * | 1979-03-02 | 1981-10-27 | Sumitomo Chemical Company, Limited | Resolution of mercaptopropionic acids |
US4385062A (en) * | 1980-01-09 | 1983-05-24 | Gruppo Lepetit S.P.A. | 1-[(-2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents |
GB2072165B (en) * | 1980-03-07 | 1983-11-23 | Lepetit Spa | 1-(2-mercaptocycloalkyl)carbonyl-l-proline derivatives the process for their manufacture the intermediates for their synthesis and their use as antihypertensive agents |
-
1981
- 1981-02-17 AU AU67366/81A patent/AU542211B2/en not_active Ceased
- 1981-02-18 ZA ZA00811069A patent/ZA811069B/xx unknown
- 1981-02-20 GR GR64199A patent/GR74121B/el unknown
- 1981-02-23 IL IL62194A patent/IL62194A/xx unknown
- 1981-02-25 IT IT19960/81A patent/IT1169217B/it active
- 1981-02-27 FI FI810615A patent/FI810615L/fi not_active Application Discontinuation
- 1981-03-02 PH PH25288A patent/PH15896A/en unknown
- 1981-03-03 CH CH1418/81A patent/CH649531A5/fr not_active IP Right Cessation
- 1981-03-04 NO NO810748A patent/NO155007C/no unknown
- 1981-03-04 JP JP2999181A patent/JPS56139456A/ja active Granted
- 1981-03-04 MA MA19290A patent/MA19086A1/fr unknown
- 1981-03-05 IE IE483/81A patent/IE50989B1/en unknown
- 1981-03-05 LU LU83186A patent/LU83186A1/fr unknown
- 1981-03-06 AT AT0104981A patent/AT375641B/de not_active IP Right Cessation
- 1981-03-06 YU YU00587/81A patent/YU58781A/xx unknown
- 1981-03-06 ES ES500158A patent/ES8201969A1/es not_active Expired
- 1981-03-06 CA CA000372483A patent/CA1144172A/en not_active Expired
- 1981-03-06 DK DK102381A patent/DK102381A/da not_active Application Discontinuation
- 1981-03-06 DE DE19813108543 patent/DE3108543A1/de not_active Ceased
- 1981-03-06 FR FR8104558A patent/FR2477539A1/fr active Granted
- 1981-03-06 BE BE0/204033A patent/BE887825A/fr not_active IP Right Cessation
- 1981-03-06 AR AR284543A patent/AR231126A1/es active
- 1981-03-06 PT PT72633A patent/PT72633B/pt unknown
- 1981-03-06 SE SE8101447A patent/SE447104B/sv not_active IP Right Cessation
- 1981-03-06 NL NL8101086A patent/NL8101086A/nl not_active Application Discontinuation
- 1981-05-20 ES ES502338A patent/ES8204718A1/es not_active Expired
-
1983
- 1983-01-26 US US06/460,972 patent/US4496743A/en not_active Expired - Fee Related
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