ES8204718A1 - Un procedimiento para preparar derivados de prolina - Google Patents
Un procedimiento para preparar derivados de prolinaInfo
- Publication number
- ES8204718A1 ES8204718A1 ES502338A ES502338A ES8204718A1 ES 8204718 A1 ES8204718 A1 ES 8204718A1 ES 502338 A ES502338 A ES 502338A ES 502338 A ES502338 A ES 502338A ES 8204718 A1 ES8204718 A1 ES 8204718A1
- Authority
- ES
- Spain
- Prior art keywords
- acylthiocycloalkyl
- carbonyl
- proline derivatives
- proline
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C61/16—Unsaturated compounds
- C07C61/20—Unsaturated compounds having a carboxyl group bound to a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE PROLINA. CONSISTE EN CONDENSAR UN ACIDO 2-ACILTIO CICLOALCOHIL-CARBOXILICO DE FORMULA GENERAL (I) CON UN SUSTRATO DE L-PROLINA, BIEN HACIENDO REACCIONAR DIRECTAMENTE EL ACIDO (I) CON ESTER TRC-BUTILICO DE L-PROLINA EN PRESENCIA DE UN AGENTE DE UNION, ESCINDIENDO DESPUES EL GRUPO TERC-BUTILICO O BIEN TRANSFORMANDO EL ACIDO (I) CON EL CORRESPONDIENTE CLORURO DE ACIDO CON SAL SODICA DE L-PROLINA, POR LO QUE SE OBTIENE UN COMPUESTO (II) QUE OPCIONALMENTE SE TRANSFORMA EN LOS CORRESPONDIENTES ESTERES DE ALCOHILO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8007756 | 1980-03-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8204718A1 true ES8204718A1 (es) | 1982-05-01 |
ES502338A0 ES502338A0 (es) | 1982-05-01 |
Family
ID=10511933
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES500158A Expired ES8201969A1 (es) | 1980-03-07 | 1981-03-06 | Procedimiento para preparar nuevos derivados de (1-(2-mer- captocicloalcohil)carbonil)-l-prolina |
ES502338A Granted ES502338A0 (es) | 1980-03-07 | 1981-05-20 | Un procedimiento para preparar derivados de prolina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES500158A Expired ES8201969A1 (es) | 1980-03-07 | 1981-03-06 | Procedimiento para preparar nuevos derivados de (1-(2-mer- captocicloalcohil)carbonil)-l-prolina |
Country Status (26)
Country | Link |
---|---|
US (1) | US4496743A (es) |
JP (1) | JPS56139456A (es) |
AR (1) | AR231126A1 (es) |
AT (1) | AT375641B (es) |
AU (1) | AU542211B2 (es) |
BE (1) | BE887825A (es) |
CA (1) | CA1144172A (es) |
CH (1) | CH649531A5 (es) |
DE (1) | DE3108543A1 (es) |
DK (1) | DK102381A (es) |
ES (2) | ES8201969A1 (es) |
FI (1) | FI810615L (es) |
FR (1) | FR2477539A1 (es) |
GR (1) | GR74121B (es) |
IE (1) | IE50989B1 (es) |
IL (1) | IL62194A (es) |
IT (1) | IT1169217B (es) |
LU (1) | LU83186A1 (es) |
MA (1) | MA19086A1 (es) |
NL (1) | NL8101086A (es) |
NO (1) | NO155007C (es) |
PH (1) | PH15896A (es) |
PT (1) | PT72633B (es) |
SE (1) | SE447104B (es) |
YU (1) | YU58781A (es) |
ZA (1) | ZA811069B (es) |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4105776A (en) * | 1976-06-21 | 1978-08-08 | E. R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
FR2394529A2 (fr) * | 1977-06-13 | 1979-01-12 | Synthelabo | Methoxy-2 benzamides et leur application en therapeutique |
US4052511A (en) * | 1976-02-13 | 1977-10-04 | E. R. Squibb & Sons, Inc. | Carboxyacylproline derivatives |
US4091024A (en) * | 1976-12-03 | 1978-05-23 | E. R. Squibb & Sons, Inc. | Pyrrolidine and piperidine-2-carboxylic acid derivatives |
US4123544A (en) * | 1977-03-02 | 1978-10-31 | Merrell Toraude S. A. | Acetylsalicylic acid derivatives |
US4108886A (en) * | 1977-03-11 | 1978-08-22 | E. R. Squibb & Sons, Inc. | Thiopropanoylamino acid derivatives |
PH15381A (en) * | 1978-02-21 | 1982-12-17 | Squibb & Sons Inc | Halogen substituted mercaptoacylamino acids |
JPS54138551A (en) * | 1978-04-14 | 1979-10-27 | Sumitomo Chem Co Ltd | Novel asymmetric synthesis of optically active 2-alkanoyl- 1,2,3,4-tetrahydro-2-naphthol compound |
CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
US4297282A (en) * | 1979-03-02 | 1981-10-27 | Sumitomo Chemical Company, Limited | Resolution of mercaptopropionic acids |
US4385062A (en) * | 1980-01-09 | 1983-05-24 | Gruppo Lepetit S.P.A. | 1-[(-2-Mercaptocycloalkyl)carbonyl]-L-proline derivatives, the process for their manufacture, the intermediates for their synthesis and their use as anti-hypertensive agents |
GB2072165B (en) * | 1980-03-07 | 1983-11-23 | Lepetit Spa | 1-(2-mercaptocycloalkyl)carbonyl-l-proline derivatives the process for their manufacture the intermediates for their synthesis and their use as antihypertensive agents |
-
1981
- 1981-02-17 AU AU67366/81A patent/AU542211B2/en not_active Ceased
- 1981-02-18 ZA ZA00811069A patent/ZA811069B/xx unknown
- 1981-02-20 GR GR64199A patent/GR74121B/el unknown
- 1981-02-23 IL IL62194A patent/IL62194A/xx unknown
- 1981-02-25 IT IT19960/81A patent/IT1169217B/it active
- 1981-02-27 FI FI810615A patent/FI810615L/fi not_active Application Discontinuation
- 1981-03-02 PH PH25288A patent/PH15896A/en unknown
- 1981-03-03 CH CH1418/81A patent/CH649531A5/fr not_active IP Right Cessation
- 1981-03-04 JP JP2999181A patent/JPS56139456A/ja active Granted
- 1981-03-04 MA MA19290A patent/MA19086A1/fr unknown
- 1981-03-04 NO NO810748A patent/NO155007C/no unknown
- 1981-03-05 IE IE483/81A patent/IE50989B1/en unknown
- 1981-03-05 LU LU83186A patent/LU83186A1/fr unknown
- 1981-03-06 ES ES500158A patent/ES8201969A1/es not_active Expired
- 1981-03-06 BE BE0/204033A patent/BE887825A/fr not_active IP Right Cessation
- 1981-03-06 CA CA000372483A patent/CA1144172A/en not_active Expired
- 1981-03-06 PT PT72633A patent/PT72633B/pt unknown
- 1981-03-06 AR AR284543A patent/AR231126A1/es active
- 1981-03-06 AT AT0104981A patent/AT375641B/de not_active IP Right Cessation
- 1981-03-06 DK DK102381A patent/DK102381A/da not_active Application Discontinuation
- 1981-03-06 DE DE19813108543 patent/DE3108543A1/de not_active Ceased
- 1981-03-06 SE SE8101447A patent/SE447104B/sv not_active IP Right Cessation
- 1981-03-06 YU YU00587/81A patent/YU58781A/xx unknown
- 1981-03-06 FR FR8104558A patent/FR2477539A1/fr active Granted
- 1981-03-06 NL NL8101086A patent/NL8101086A/nl not_active Application Discontinuation
- 1981-05-20 ES ES502338A patent/ES502338A0/es active Granted
-
1983
- 1983-01-26 US US06/460,972 patent/US4496743A/en not_active Expired - Fee Related
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