ZA806308B - Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2r-cis)-(3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it - Google Patents

Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2r-cis)-(3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it

Info

Publication number
ZA806308B
ZA806308B ZA00806308A ZA806308A ZA806308B ZA 806308 B ZA806308 B ZA 806308B ZA 00806308 A ZA00806308 A ZA 00806308A ZA 806308 A ZA806308 A ZA 806308A ZA 806308 B ZA806308 B ZA 806308B
Authority
ZA
South Africa
Prior art keywords
methyloxiranyl
phosphonate
propanediol
hydroxymethyl
cis
Prior art date
Application number
ZA00806308A
Other languages
English (en)
Inventor
D Chiarino
V Ferrari
D Bella
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of ZA806308B publication Critical patent/ZA806308B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ZA00806308A 1979-10-18 1980-10-14 Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2r-cis)-(3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it ZA806308B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26581/79A IT1124610B (it) 1979-10-18 1979-10-18 Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato

Publications (1)

Publication Number Publication Date
ZA806308B true ZA806308B (en) 1981-08-26

Family

ID=11219823

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00806308A ZA806308B (en) 1979-10-18 1980-10-14 Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2r-cis)-(3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it

Country Status (23)

Country Link
US (1) US4863908A (fr)
EP (1) EP0027597B1 (fr)
JP (1) JPS5677290A (fr)
AT (1) ATE2005T1 (fr)
AU (1) AU532089B2 (fr)
BE (1) BE885756A (fr)
BG (1) BG61368B2 (fr)
CA (1) CA1163274A (fr)
CH (1) CH644613A5 (fr)
DE (1) DE3061359D1 (fr)
DK (1) DK147261C (fr)
ES (1) ES495870A0 (fr)
FR (1) FR2467856A1 (fr)
GB (1) GB2062640B (fr)
GR (1) GR70312B (fr)
IE (1) IE50319B1 (fr)
IL (1) IL61221A (fr)
IT (1) IT1124610B (fr)
LU (1) LU88335I2 (fr)
MX (1) MX9203181A (fr)
NL (1) NL930041I2 (fr)
YU (1) YU41742B (fr)
ZA (1) ZA806308B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1136652B (it) * 1981-06-04 1986-09-03 Crinos Industria Farmaco Compesizione farmaceutica di fosfomicina in compresse da succhiare
CH660305A5 (de) * 1984-10-05 1987-04-15 Schering Spa Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.
IT1231013B (it) * 1989-07-27 1991-11-08 Zambon Spa Mono (2 ammonio 2 idrossimetil 1,3 propandiolo)(2r,cis) 1,2 epossipropil fosfonato avente migliorate caratteristiche di stabilita' e lavorabilita'.
US5191094A (en) * 1989-07-27 1993-03-02 Zambon Group S.P.A. Mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability and processing
ITMI20021725A1 (it) 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
ES2244333B1 (es) * 2004-05-18 2006-08-01 Simbec Iberica, Sl Preparado farmaceutico oral de fosfomicina estable y apto para diabeticos.
EP1762573A1 (fr) 2005-09-08 2007-03-14 Interquim, S.A. De C.V. Procédé de préparation de sels de fosfomycin
ES2345591B1 (es) * 2009-03-10 2011-07-21 Labiana Pharmaceuticals, S.L. Procedimiento para la preparacion de fosfomicina trometamol.
CN102351902A (zh) * 2011-08-12 2012-02-15 山西仟源制药股份有限公司 磷霉素单氨丁三醇的制备方法
CN102807586B (zh) 2012-08-31 2015-05-13 东北制药集团股份有限公司 磷霉素氨盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322767A (en) * 1963-06-03 1967-05-30 Gabriel G Nabas Tham salts
US3639590A (en) * 1967-07-25 1972-02-01 Merck & Co Inc Antibacterial composition containing (-) (cis-1 2-epoxypropyl) phosphoric acid
US3641063A (en) * 1968-01-22 1972-02-08 Merck & Co Inc Antibiotic purification process
US3914231A (en) * 1970-09-04 1975-10-21 Merck & Co Inc ({31 )(Cis-1,2-epoxypropyl)-phosphonic acid and salts thereof
US3940483A (en) * 1971-02-05 1976-02-24 E. R. Squibb & Sons, Inc. Antibiotic compositions and method
DE2134672A1 (de) * 1971-07-08 1973-01-25 Josef Dipl Chem Dr Rer N Klosa Wasserloesliches acetylsalicylsaeuresalz, dessen herstellung, zubereitung und anwendung
IT1112282B (it) * 1978-07-19 1986-01-13 Zambon Spa Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
GB2158828B (en) * 1984-04-25 1987-12-09 Espanola De La Penicilina Y An Salts of fosfomycin

Also Published As

Publication number Publication date
FR2467856A1 (fr) 1981-04-30
BE885756A (fr) 1981-04-16
IT1124610B (it) 1986-05-07
JPS5677290A (en) 1981-06-25
CA1163274A (fr) 1984-03-06
CH644613A5 (it) 1984-08-15
NL930041I2 (nl) 1993-11-16
ES8200700A1 (es) 1981-11-16
ATE2005T1 (de) 1982-12-15
DE3061359D1 (en) 1983-01-20
LU88335I2 (fr) 1994-05-04
IE50319B1 (en) 1986-04-02
EP0027597B1 (fr) 1982-12-15
IL61221A0 (en) 1980-12-31
DK147261B (da) 1984-05-28
BG61368B2 (bg) 1997-06-30
FR2467856B1 (fr) 1984-10-05
AU6341880A (en) 1981-04-30
GB2062640B (en) 1983-09-14
IL61221A (en) 1985-02-28
EP0027597A1 (fr) 1981-04-29
IT7926581A0 (it) 1979-10-18
US4863908A (en) 1989-09-05
YU266880A (en) 1983-06-30
NL930041I1 (nl) 1993-08-02
JPS6317836B2 (fr) 1988-04-15
GB2062640A (en) 1981-05-28
GR70312B (fr) 1982-09-09
ES495870A0 (es) 1981-11-16
DK147261C (da) 1984-11-26
AU532089B2 (en) 1983-09-15
DK442080A (da) 1981-04-19
MX9203181A (es) 1992-07-01
YU41742B (en) 1987-12-31
IE802062L (en) 1981-04-18

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