FR2467856B1 - - Google Patents

Info

Publication number
FR2467856B1
FR2467856B1 FR8022221A FR8022221A FR2467856B1 FR 2467856 B1 FR2467856 B1 FR 2467856B1 FR 8022221 A FR8022221 A FR 8022221A FR 8022221 A FR8022221 A FR 8022221A FR 2467856 B1 FR2467856 B1 FR 2467856B1
Authority
FR
France
Prior art keywords
methyloxiranyl
phosphonate
propanediol
hydroxymethyl
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8022221A
Other languages
English (en)
Other versions
FR2467856A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Publication of FR2467856A1 publication Critical patent/FR2467856A1/fr
Application granted granted Critical
Publication of FR2467856B1 publication Critical patent/FR2467856B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
FR8022221A 1979-10-18 1980-10-17 (2r-cis)-(3-methyloxyranyl)-phosphonate de mono-(2-ammonium-2-hydroxymethyl-1,3-propane-diol), procede pour sa preparation et compositions pharmaceutiques qui le contiennent Granted FR2467856A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26581/79A IT1124610B (it) 1979-10-18 1979-10-18 Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato

Publications (2)

Publication Number Publication Date
FR2467856A1 FR2467856A1 (fr) 1981-04-30
FR2467856B1 true FR2467856B1 (fr) 1984-10-05

Family

ID=11219823

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8022221A Granted FR2467856A1 (fr) 1979-10-18 1980-10-17 (2r-cis)-(3-methyloxyranyl)-phosphonate de mono-(2-ammonium-2-hydroxymethyl-1,3-propane-diol), procede pour sa preparation et compositions pharmaceutiques qui le contiennent

Country Status (23)

Country Link
US (1) US4863908A (fr)
EP (1) EP0027597B1 (fr)
JP (1) JPS5677290A (fr)
AT (1) ATE2005T1 (fr)
AU (1) AU532089B2 (fr)
BE (1) BE885756A (fr)
BG (1) BG61368B2 (fr)
CA (1) CA1163274A (fr)
CH (1) CH644613A5 (fr)
DE (1) DE3061359D1 (fr)
DK (1) DK147261C (fr)
ES (1) ES495870A0 (fr)
FR (1) FR2467856A1 (fr)
GB (1) GB2062640B (fr)
GR (1) GR70312B (fr)
IE (1) IE50319B1 (fr)
IL (1) IL61221A (fr)
IT (1) IT1124610B (fr)
LU (1) LU88335I2 (fr)
MX (1) MX9203181A (fr)
NL (1) NL930041I2 (fr)
YU (1) YU41742B (fr)
ZA (1) ZA806308B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1136652B (it) * 1981-06-04 1986-09-03 Crinos Industria Farmaco Compesizione farmaceutica di fosfomicina in compresse da succhiare
CH660305A5 (de) * 1984-10-05 1987-04-15 Schering Spa Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren.
IT1231013B (it) * 1989-07-27 1991-11-08 Zambon Spa Mono (2 ammonio 2 idrossimetil 1,3 propandiolo)(2r,cis) 1,2 epossipropil fosfonato avente migliorate caratteristiche di stabilita' e lavorabilita'.
US5191094A (en) * 1989-07-27 1993-03-02 Zambon Group S.P.A. Mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability and processing
ITMI20021725A1 (it) * 2002-08-01 2002-10-31 Zambon Spa Composizioni farmaceutiche ad attivita' antibiotica.
ES2244333B1 (es) * 2004-05-18 2006-08-01 Simbec Iberica, Sl Preparado farmaceutico oral de fosfomicina estable y apto para diabeticos.
EP1762573A1 (fr) 2005-09-08 2007-03-14 Interquim, S.A. De C.V. Procédé de préparation de sels de fosfomycin
ES2345591B1 (es) * 2009-03-10 2011-07-21 Labiana Pharmaceuticals, S.L. Procedimiento para la preparacion de fosfomicina trometamol.
CN102351902A (zh) * 2011-08-12 2012-02-15 山西仟源制药股份有限公司 磷霉素单氨丁三醇的制备方法
CN102807586B (zh) 2012-08-31 2015-05-13 东北制药集团股份有限公司 磷霉素氨盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322767A (en) * 1963-06-03 1967-05-30 Gabriel G Nabas Tham salts
US3639590A (en) * 1967-07-25 1972-02-01 Merck & Co Inc Antibacterial composition containing (-) (cis-1 2-epoxypropyl) phosphoric acid
US3641063A (en) * 1968-01-22 1972-02-08 Merck & Co Inc Antibiotic purification process
US3914231A (en) * 1970-09-04 1975-10-21 Merck & Co Inc ({31 )(Cis-1,2-epoxypropyl)-phosphonic acid and salts thereof
US3940483A (en) * 1971-02-05 1976-02-24 E. R. Squibb & Sons, Inc. Antibiotic compositions and method
DE2134672A1 (de) * 1971-07-08 1973-01-25 Josef Dipl Chem Dr Rer N Klosa Wasserloesliches acetylsalicylsaeuresalz, dessen herstellung, zubereitung und anwendung
IT1112282B (it) * 1978-07-19 1986-01-13 Zambon Spa Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato
GB2158828B (en) * 1984-04-25 1987-12-09 Espanola De La Penicilina Y An Salts of fosfomycin

Also Published As

Publication number Publication date
GB2062640B (en) 1983-09-14
IE802062L (en) 1981-04-18
DE3061359D1 (en) 1983-01-20
EP0027597A1 (fr) 1981-04-29
IE50319B1 (en) 1986-04-02
ATE2005T1 (de) 1982-12-15
LU88335I2 (fr) 1994-05-04
ES8200700A1 (es) 1981-11-16
AU532089B2 (en) 1983-09-15
IT7926581A0 (it) 1979-10-18
BE885756A (fr) 1981-04-16
DK147261B (da) 1984-05-28
IT1124610B (it) 1986-05-07
GR70312B (fr) 1982-09-09
FR2467856A1 (fr) 1981-04-30
MX9203181A (es) 1992-07-01
CA1163274A (fr) 1984-03-06
AU6341880A (en) 1981-04-30
EP0027597B1 (fr) 1982-12-15
DK147261C (da) 1984-11-26
YU41742B (en) 1987-12-31
JPS6317836B2 (fr) 1988-04-15
BG61368B2 (bg) 1997-06-30
JPS5677290A (en) 1981-06-25
ES495870A0 (es) 1981-11-16
IL61221A (en) 1985-02-28
US4863908A (en) 1989-09-05
NL930041I2 (nl) 1993-11-16
CH644613A5 (it) 1984-08-15
NL930041I1 (nl) 1993-08-02
YU266880A (en) 1983-06-30
ZA806308B (en) 1981-08-26
GB2062640A (en) 1981-05-28
IL61221A0 (en) 1980-12-31
DK442080A (da) 1981-04-19

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Legal Events

Date Code Title Description
CP Supplementary protection certificate (spc) filed

Free format text: PRODUCT NAME: FOSFOMYCIN TROMETHAMINE; NAT. REGISTRATION NO/DATE: NL 15513 19890723; FIRST REGISTRATION: IT - 25680024 19860712

Spc suppl protection certif: 93C0009

Filing date: 19930324

CP Supplementary protection certificate (spc) filed

Free format text: 93C0009, 930324

CR Request for supplementary protection certificate laid open to the public (eec regulation of 18 june 1992)

Free format text: 93C0009, 930324

CP Supplementary protection certificate (spc) filed
CP Supplementary protection certificate (spc) filed

Free format text: 93C0009, 930324

CR Request for supplementary protection certificate laid open to the public (eec regulation of 18 june 1992)

Free format text: 93C0009, 930324

CY Supplementary certificate of protection granted (eec regulation of 18 june 1992)

Free format text: 93C0009, 930324, EXPIRES:20010712

CA Change of address
TP Transmission of property
TP Transmission of property