IT7926581A0 - (2r-cis)-(0-metilossiranil)fosfonatmono(2-ammonio-2-idrossimetil-1,3-p o. ropandiolo) - Google Patents
(2r-cis)-(0-metilossiranil)fosfonatmono(2-ammonio-2-idrossimetil-1,3-p o. ropandiolo)Info
- Publication number
- IT7926581A0 IT7926581A0 IT7926581A IT2658179A IT7926581A0 IT 7926581 A0 IT7926581 A0 IT 7926581A0 IT 7926581 A IT7926581 A IT 7926581A IT 2658179 A IT2658179 A IT 2658179A IT 7926581 A0 IT7926581 A0 IT 7926581A0
- Authority
- IT
- Italy
- Prior art keywords
- ropandiol
- phosphonatmono
- methyloxyranyl
- hydroxymethyl
- cis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
- C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT26581/79A IT1124610B (it) | 1979-10-18 | 1979-10-18 | Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato |
IE2062/80A IE50319B1 (en) | 1979-10-18 | 1980-10-03 | Fosfomycin salt |
IL61221A IL61221A (en) | 1979-10-18 | 1980-10-07 | Mono(2-ammonium-2-hydroxy-methyl-1,3-propanediol)(2r-cis-(3-methyloxiranyl)phosphonate,its preparation and pharmaceutical compositions containing it |
DE8080106108T DE3061359D1 (en) | 1979-10-18 | 1980-10-08 | Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2r-cis)-(3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it |
EP80106108A EP0027597B1 (en) | 1979-10-18 | 1980-10-08 | Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2r-cis)-(3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it |
AT80106108T ATE2005T1 (de) | 1979-10-18 | 1980-10-08 | Mono(2-ammonium-2-hydroxymethyl-1,3propandiol)(2r-cis)-(3-methyloxiranyl)phosphona , seine herstellung und es enthaltende pharmazeutische zusammensetzungen. |
GB8032736A GB2062640B (en) | 1979-10-18 | 1980-10-10 | Fosfomycin salt |
CH762280A CH644613A5 (it) | 1979-10-18 | 1980-10-13 | Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(3-metilossiranil)fosfonato, sua preparazione e composizioni farmaceutiche che lo contengono. |
ES495870A ES495870A0 (es) | 1979-10-18 | 1980-10-13 | Un procedimiento para la preparacion de mono(2-amonio-2-hi- droximetil-1,3-propandiol)(2r-cis)-(3-metiloxiranil)fosfona-to |
ZA00806308A ZA806308B (en) | 1979-10-18 | 1980-10-14 | Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol)(2r-cis)-(3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it |
GR63159A GR70312B (it) | 1979-10-18 | 1980-10-15 | |
BE0/202498A BE885756A (fr) | 1979-10-18 | 1980-10-16 | Mono (2-ammonium-2-hydroxymethyl-1,3-propanediol)(2r-cis)-(3-methyloxiranyl)phosphonate, sa preparation et compositions pharmaceutiques en contenant |
CA000362531A CA1163274A (en) | 1979-10-18 | 1980-10-16 | Mono(2-ammonium-2-hydroxymethyl-1,3-propanediol) (2r-cis)-(3-methyloxiranyl) phosphonate, its preparation and pharmaceutical compositions containing it |
AU63418/80A AU532089B2 (en) | 1979-10-18 | 1980-10-16 | Mono (2-ammonium-2-hydrozymethyl-1,3-propanediol) (2r-cis) (3-methyloxiranyl) phosphonate |
DK442080A DK147261C (da) | 1979-10-18 | 1980-10-17 | Analogifremgangsmaade til fremstilling af mono(2-ammonium-2-hydroxymethyl-1,3-propandiol)(2r-cis)-(3-methyloxiranyl)phosphonat |
JP14455280A JPS5677290A (en) | 1979-10-18 | 1980-10-17 | Novel therapeutic compound* its manufacture and drug composition containing it |
FR8022221A FR2467856A1 (fr) | 1979-10-18 | 1980-10-17 | (2r-cis)-(3-methyloxyranyl)-phosphonate de mono-(2-ammonium-2-hydroxymethyl-1,3-propane-diol), procede pour sa preparation et compositions pharmaceutiques qui le contiennent |
YU2668/80A YU41742B (en) | 1979-10-18 | 1980-10-17 | Process for obtaining mano-(2-ammonium-2-hydroxy methyl-1,3-propane-dio)(2cr-cis)(3-methyloxyranyl) phosphonate |
US07/097,425 US4863908A (en) | 1979-10-18 | 1987-09-15 | Mono(2-ammonium-2-hydroxymethyl-1,3 propanediol)(2R-cis)-3-methyloxiranyl)phosphonate, its preparation and pharmaceutical compositions containing it |
MX9203181A MX9203181A (es) | 1979-10-18 | 1992-06-23 | Sal de mono(2-amonio-2-hidroximetil-1,3-propandiol)(2r-cis)-(3-metiloxiranil) -fosfonato y composicion farmaceutica que la contiene. |
NL930041C NL930041I2 (nl) | 1979-10-18 | 1993-05-28 | Mono (2-ammonium-2-hydroxymethyl-1,3-propaandiol)-(2R-cis)-(3-methyloxiranylfosfonaat), de bereidingdaarvan en farmaceutische preparaten die deze ver binding bevatten. |
LU88335C LU88335I2 (fr) | 1979-10-18 | 1993-06-24 | Fosomycine trometamol (Monuril) |
BG98592A BG61368B2 (bg) | 1979-10-18 | 1994-02-25 | Моно(2-амониев-2-хидроксиметил-1,3-пропандиол)(2r-сis)- (3-метоксиранил)фосфонат,получаване и фармацевтични състави,които го съдържат |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT26581/79A IT1124610B (it) | 1979-10-18 | 1979-10-18 | Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato |
Publications (2)
Publication Number | Publication Date |
---|---|
IT7926581A0 true IT7926581A0 (it) | 1979-10-18 |
IT1124610B IT1124610B (it) | 1986-05-07 |
Family
ID=11219823
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT26581/79A IT1124610B (it) | 1979-10-18 | 1979-10-18 | Mono(2-ammonio-2-idrossimetil-1,3-propandiolo) (2r-cis)-(o-metilossiranil)fosfonato |
Country Status (23)
Country | Link |
---|---|
US (1) | US4863908A (it) |
EP (1) | EP0027597B1 (it) |
JP (1) | JPS5677290A (it) |
AT (1) | ATE2005T1 (it) |
AU (1) | AU532089B2 (it) |
BE (1) | BE885756A (it) |
BG (1) | BG61368B2 (it) |
CA (1) | CA1163274A (it) |
CH (1) | CH644613A5 (it) |
DE (1) | DE3061359D1 (it) |
DK (1) | DK147261C (it) |
ES (1) | ES495870A0 (it) |
FR (1) | FR2467856A1 (it) |
GB (1) | GB2062640B (it) |
GR (1) | GR70312B (it) |
IE (1) | IE50319B1 (it) |
IL (1) | IL61221A (it) |
IT (1) | IT1124610B (it) |
LU (1) | LU88335I2 (it) |
MX (1) | MX9203181A (it) |
NL (1) | NL930041I2 (it) |
YU (1) | YU41742B (it) |
ZA (1) | ZA806308B (it) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1136652B (it) * | 1981-06-04 | 1986-09-03 | Crinos Industria Farmaco | Compesizione farmaceutica di fosfomicina in compresse da succhiare |
CH660305A5 (de) * | 1984-10-05 | 1987-04-15 | Schering Spa | Wasserloesliche pharmazeutische zusammensetzungen auf der basis von salzen der (-)cis-1,2-epoxypropylphosphonsaeure mit aminosaeuren. |
IT1231013B (it) * | 1989-07-27 | 1991-11-08 | Zambon Spa | Mono (2 ammonio 2 idrossimetil 1,3 propandiolo)(2r,cis) 1,2 epossipropil fosfonato avente migliorate caratteristiche di stabilita' e lavorabilita'. |
US5191094A (en) * | 1989-07-27 | 1993-03-02 | Zambon Group S.P.A. | Mono (2-ammonium-2-hydroxymethyl-1,3-propanediol) (2R,cis)-1,2-epoxypropyl-phosphonate with improved characteristics of stability and processing |
ITMI20021725A1 (it) * | 2002-08-01 | 2002-10-31 | Zambon Spa | Composizioni farmaceutiche ad attivita' antibiotica. |
ES2244333B1 (es) * | 2004-05-18 | 2006-08-01 | Simbec Iberica, Sl | Preparado farmaceutico oral de fosfomicina estable y apto para diabeticos. |
EP1762573A1 (en) | 2005-09-08 | 2007-03-14 | Interquim, S.A. De C.V. | A process for the preparation of fosfomycin salts |
ES2345591B1 (es) * | 2009-03-10 | 2011-07-21 | Labiana Pharmaceuticals, S.L. | Procedimiento para la preparacion de fosfomicina trometamol. |
CN102351902A (zh) * | 2011-08-12 | 2012-02-15 | 山西仟源制药股份有限公司 | 磷霉素单氨丁三醇的制备方法 |
CN102807586B (zh) | 2012-08-31 | 2015-05-13 | 东北制药集团股份有限公司 | 磷霉素氨盐的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3322767A (en) * | 1963-06-03 | 1967-05-30 | Gabriel G Nabas | Tham salts |
US3639590A (en) * | 1967-07-25 | 1972-02-01 | Merck & Co Inc | Antibacterial composition containing (-) (cis-1 2-epoxypropyl) phosphoric acid |
US3641063A (en) * | 1968-01-22 | 1972-02-08 | Merck & Co Inc | Antibiotic purification process |
US3914231A (en) * | 1970-09-04 | 1975-10-21 | Merck & Co Inc | ({31 )(Cis-1,2-epoxypropyl)-phosphonic acid and salts thereof |
US3940483A (en) * | 1971-02-05 | 1976-02-24 | E. R. Squibb & Sons, Inc. | Antibiotic compositions and method |
DE2134672A1 (de) * | 1971-07-08 | 1973-01-25 | Josef Dipl Chem Dr Rer N Klosa | Wasserloesliches acetylsalicylsaeuresalz, dessen herstellung, zubereitung und anwendung |
IT1112282B (it) * | 1978-07-19 | 1986-01-13 | Zambon Spa | Bis-(2-ammonio-2-idrossimetil-1,3-propandiolo)(2r-cis)-(3-metilossiranil)fosfonato |
GB2158828B (en) * | 1984-04-25 | 1987-12-09 | Espanola De La Penicilina Y An | Salts of fosfomycin |
-
1979
- 1979-10-18 IT IT26581/79A patent/IT1124610B/it active
-
1980
- 1980-10-03 IE IE2062/80A patent/IE50319B1/en not_active IP Right Cessation
- 1980-10-07 IL IL61221A patent/IL61221A/xx not_active IP Right Cessation
- 1980-10-08 DE DE8080106108T patent/DE3061359D1/de not_active Expired
- 1980-10-08 EP EP80106108A patent/EP0027597B1/en not_active Expired
- 1980-10-08 AT AT80106108T patent/ATE2005T1/de active
- 1980-10-10 GB GB8032736A patent/GB2062640B/en not_active Expired
- 1980-10-13 ES ES495870A patent/ES495870A0/es active Granted
- 1980-10-13 CH CH762280A patent/CH644613A5/it not_active IP Right Cessation
- 1980-10-14 ZA ZA00806308A patent/ZA806308B/xx unknown
- 1980-10-15 GR GR63159A patent/GR70312B/el unknown
- 1980-10-16 CA CA000362531A patent/CA1163274A/en not_active Expired
- 1980-10-16 AU AU63418/80A patent/AU532089B2/en not_active Expired
- 1980-10-16 BE BE0/202498A patent/BE885756A/fr not_active IP Right Cessation
- 1980-10-17 YU YU2668/80A patent/YU41742B/xx unknown
- 1980-10-17 JP JP14455280A patent/JPS5677290A/ja active Granted
- 1980-10-17 DK DK442080A patent/DK147261C/da not_active IP Right Cessation
- 1980-10-17 FR FR8022221A patent/FR2467856A1/fr active Granted
-
1987
- 1987-09-15 US US07/097,425 patent/US4863908A/en not_active Expired - Lifetime
-
1992
- 1992-06-23 MX MX9203181A patent/MX9203181A/es unknown
-
1993
- 1993-05-28 NL NL930041C patent/NL930041I2/nl unknown
- 1993-06-24 LU LU88335C patent/LU88335I2/fr unknown
-
1994
- 1994-02-25 BG BG98592A patent/BG61368B2/bg unknown
Also Published As
Publication number | Publication date |
---|---|
BG61368B2 (bg) | 1997-06-30 |
AU532089B2 (en) | 1983-09-15 |
DK147261B (da) | 1984-05-28 |
FR2467856A1 (fr) | 1981-04-30 |
IL61221A (en) | 1985-02-28 |
ES8200700A1 (es) | 1981-11-16 |
NL930041I2 (nl) | 1993-11-16 |
GB2062640B (en) | 1983-09-14 |
ZA806308B (en) | 1981-08-26 |
GR70312B (it) | 1982-09-09 |
EP0027597B1 (en) | 1982-12-15 |
LU88335I2 (fr) | 1994-05-04 |
IE50319B1 (en) | 1986-04-02 |
DK147261C (da) | 1984-11-26 |
DE3061359D1 (en) | 1983-01-20 |
MX9203181A (es) | 1992-07-01 |
NL930041I1 (nl) | 1993-08-02 |
YU266880A (en) | 1983-06-30 |
FR2467856B1 (it) | 1984-10-05 |
EP0027597A1 (en) | 1981-04-29 |
CA1163274A (en) | 1984-03-06 |
YU41742B (en) | 1987-12-31 |
DK442080A (da) | 1981-04-19 |
ATE2005T1 (de) | 1982-12-15 |
IE802062L (en) | 1981-04-18 |
AU6341880A (en) | 1981-04-30 |
BE885756A (fr) | 1981-04-16 |
JPS5677290A (en) | 1981-06-25 |
GB2062640A (en) | 1981-05-28 |
US4863908A (en) | 1989-09-05 |
ES495870A0 (es) | 1981-11-16 |
IT1124610B (it) | 1986-05-07 |
IL61221A0 (en) | 1980-12-31 |
JPS6317836B2 (it) | 1988-04-15 |
CH644613A5 (it) | 1984-08-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ITCP | Complementary protection certificate |
Free format text: CCP 324 |
|
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950626 |