ZA80331B - Piperidine derivatives - Google Patents

Piperidine derivatives

Info

Publication number
ZA80331B
ZA80331B ZA00800331A ZA80331A ZA80331B ZA 80331 B ZA80331 B ZA 80331B ZA 00800331 A ZA00800331 A ZA 00800331A ZA 80331 A ZA80331 A ZA 80331A ZA 80331 B ZA80331 B ZA 80331B
Authority
ZA
South Africa
Prior art keywords
piperidine derivatives
piperidine
derivatives
Prior art date
Application number
ZA00800331A
Other languages
English (en)
Inventor
A Carr
G Wright
J Dolfini
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ZA80331B publication Critical patent/ZA80331B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA00800331A 1979-04-10 1980-01-21 Piperidine derivatives ZA80331B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/028,872 US4254130A (en) 1979-04-10 1979-04-10 Piperidine derivatives

Publications (1)

Publication Number Publication Date
ZA80331B true ZA80331B (en) 1981-01-28

Family

ID=21845986

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA00800331A ZA80331B (en) 1979-04-10 1980-01-21 Piperidine derivatives

Country Status (18)

Country Link
US (1) US4254130A (de)
JP (1) JPS55139360A (de)
AT (1) AT376207B (de)
AU (1) AU536463B2 (de)
BE (1) BE882704A (de)
CA (1) CA1123439A (de)
CH (1) CH648019A5 (de)
DE (1) DE3005948A1 (de)
DK (1) DK160250C (de)
ES (1) ES8103734A1 (de)
FR (1) FR2453853A1 (de)
IL (1) IL59157A (de)
IT (1) IT1144079B (de)
NL (1) NL190664C (de)
NO (1) NO154964C (de)
NZ (1) NZ192615A (de)
SE (1) SE448727B (de)
ZA (1) ZA80331B (de)

Families Citing this family (47)

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US5231105A (en) * 1987-06-02 1993-07-27 Ajinomoto Co., Inc. Ethylamine derivatives and antihypertensives containing the same
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
JP2548800Y2 (ja) * 1991-09-13 1997-09-24 株式会社小糸製作所 自動車用ヘッドランプ
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
WO1993021156A1 (en) * 1992-04-10 1993-10-28 Merrell Dow Pharmaceuticals Inc. 4-diphenylmethyl piperidine derivatives and process for their preparation
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
JP3034047B2 (ja) * 1993-06-24 2000-04-17 オールバニー・モレキュラー・リサーチ・インコーポレイテッド ピペリジン誘導体及びそれらの製造法
US20020007068A1 (en) * 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
NZ267830A (en) * 1993-06-25 1998-05-27 Merrell Pharma Inc Preparation of 4-diphenylmethyl or 4-diphenylmethoxy piperidine derivatives and intermediates therefor
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
CN1907967B (zh) 1994-05-18 2012-07-04 安万特萨博Ⅱ有限公司 抗组胺哌啶衍生物,其多晶形物和假同晶物的无水和水合物形式的制备方法
WO1996006094A1 (en) 1994-08-25 1996-02-29 Merrell Pharmaceuticals Inc. Novel substituted piperidines useful for the treatment of allergic diseases
KR100405116B1 (ko) * 1995-02-28 2004-02-05 아벤티스 파마슈티칼스 인크. 피페리디노알칸올화합물에대한약제학적조성물
MX9708612A (es) * 1995-05-08 1998-02-28 Hoechst Marion Roussel Inc Derivados de alfa-(alquilfenilo sustituido)-4-(hidroxidifenilmetil)-1-piperidinbutanol, su preparacion y su uso como antihistaminas, agentes antialergicos, y broncodilatadores.
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) * 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
ES2192781T3 (es) * 1997-08-26 2003-10-16 Aventis Pharma Inc Composicion farmaceutica para combinacion de piperidinoalcanol y un descongestivo.
US6673933B2 (en) 1998-07-02 2004-01-06 Aventis Pharmaceutical Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
EP1616861A3 (de) * 2004-06-15 2006-02-08 Dipharma S.p.A. Verfahren zur Herstellung von Keto-Verbindungen
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
BRPI0618643A2 (pt) 2005-11-09 2011-09-06 Combinatorx Inc composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
ITMI20070987A1 (it) * 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
EP2289867A3 (de) 2009-08-19 2012-04-25 Jubilant Organosys Limited Verfahren zur Herstellung von 4-(4-Halogen-1-oxybutyl)-alpha,alpha-dimethylbenzolessigsäure oder Alkylestern davon
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
EP2371817A1 (de) 2010-04-01 2011-10-05 Arevipharma GmbH Verfahren zur Herstellung von 1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanon und Säureadditionssalze daraus
EP2578570A1 (de) 2011-10-07 2013-04-10 Almirall, S.A. Neues Verfahren zur Herstellung von 5-(2-{[6-(2,2-Difluor-2-phenylethoxy)hexyl]amino}-1(R)-hydroxyethyl)-8-hydroxychinolin-2(1H)-on mittels neuen Synthesezwischenstoffen
EP2641900A1 (de) 2012-03-20 2013-09-25 Almirall, S.A. Neuartige polymorphe Kristallformen von 5-(2-{[6-(2,2-difluor-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxychinolin-2(1H)-on, Heminapadisylat als Agonist des beta2-adrenergen Rezeptors
CN102659667B (zh) * 2012-04-20 2013-08-14 浙江启明药业有限公司 一种非索非那定关键中间体的合成方法
EP4647423A1 (de) * 2023-01-03 2025-11-12 Chengdu Shibeikang Biomedical Technology Co., Ltd. Kristalline form und amorphe form von carebastin-p-toluolsulfonat

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
BE794596A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Piperidinoalcanone-oximes substituees et leur procede de preparation
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines

Also Published As

Publication number Publication date
CA1123439A (en) 1982-05-11
SE448727B (sv) 1987-03-16
FR2453853B1 (de) 1982-07-09
NL8000762A (nl) 1980-10-14
AU5501880A (en) 1980-10-16
CH648019A5 (de) 1985-02-28
NO154964C (no) 1987-01-21
IT1144079B (it) 1986-10-29
DE3005948C2 (de) 1989-10-05
DE3005948A1 (de) 1980-10-30
SE8002635L (sv) 1980-10-11
AU536463B2 (en) 1984-05-10
ES489933A0 (es) 1981-03-16
FR2453853A1 (fr) 1980-11-07
NO801015L (no) 1980-10-13
ES8103734A1 (es) 1981-03-16
NL190664B (nl) 1994-01-17
DK160250B (da) 1991-02-18
IL59157A (en) 1984-02-29
IL59157A0 (en) 1980-05-30
DK133080A (da) 1980-10-11
DK160250C (da) 1991-07-22
ATA126080A (de) 1984-03-15
NO154964B (no) 1986-10-13
AT376207B (de) 1984-10-25
IT8047919A0 (it) 1980-02-15
JPS55139360A (en) 1980-10-31
NZ192615A (en) 1982-02-23
US4254130A (en) 1981-03-03
BE882704A (fr) 1980-07-31
NL190664C (nl) 1994-06-16

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